GAGs Flashcards
Hyaluronan Function
Forms large PG aggregates; doesn’t attach to PRO core
Hyaluronan Location
Synovial fluid, vitreous humor, loose CT, healing CT, cartilage
Hyaluronan Composition
Glucouronate Uronic Acid; Glucosamine
Chondroitin Sulfate (CS) Location
Cartilage, bone, heart valves, tendons, ligs
Chondroitin Sulfate (CS) Function
Most abundant GAG (related to high compression)
Chondroitin Sulfate (CS) Composition
Glucouronate; Galactosamine with 4- or 6-sulfate
Heparan Sulfate (HS) Location
Basement Membranes, cell surfaces
Heparan Sulfate (HS) Function
Interacts with numerous PROs
Heparan Sulfate (HS) Composition
Glucouronate, glucosamine, variable sulfation
Heparin Location
Intracellular Granules in Mast Cells lining arteries
Heparin Comments
Key structural unit is 3-glucosamine & 2-glucouronate
Heparin Composition
Glucouronate, iduronate glucosamine, variable sulfation
Dermatan Sulfate Location
Skin, BVs, Tendons, Ligs
Dermatan Sulfate Comments
Lots in areas of high tensile stress
Dermatan Sulfate Composition
Iduronate, galactosamine