GAGs Flashcards

0
Q

Hyaluronan Function

A

Forms large PG aggregates; doesn’t attach to PRO core

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1
Q

Hyaluronan Location

A

Synovial fluid, vitreous humor, loose CT, healing CT, cartilage

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2
Q

Hyaluronan Composition

A

Glucouronate Uronic Acid; Glucosamine

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3
Q

Chondroitin Sulfate (CS) Location

A

Cartilage, bone, heart valves, tendons, ligs

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4
Q

Chondroitin Sulfate (CS) Function

A

Most abundant GAG (related to high compression)

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5
Q

Chondroitin Sulfate (CS) Composition

A

Glucouronate; Galactosamine with 4- or 6-sulfate

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6
Q

Heparan Sulfate (HS) Location

A

Basement Membranes, cell surfaces

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7
Q

Heparan Sulfate (HS) Function

A

Interacts with numerous PROs

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8
Q

Heparan Sulfate (HS) Composition

A

Glucouronate, glucosamine, variable sulfation

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9
Q

Heparin Location

A

Intracellular Granules in Mast Cells lining arteries

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10
Q

Heparin Comments

A

Key structural unit is 3-glucosamine & 2-glucouronate

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11
Q

Heparin Composition

A

Glucouronate, iduronate glucosamine, variable sulfation

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12
Q

Dermatan Sulfate Location

A

Skin, BVs, Tendons, Ligs

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13
Q

Dermatan Sulfate Comments

A

Lots in areas of high tensile stress

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14
Q

Dermatan Sulfate Composition

A

Iduronate, galactosamine

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15
Q

Karatan Sulfate (KS) Location

A

Cornea, Bone, Cartilage

16
Q

Karatan Sulfate (KS) Comments

A

Forms large part of PG aggregates in Cartilage

17
Q

Karatan Sulfate (KS) Composition

A

Galactose, glucosamine