Gabapentin and pregabalin Flashcards
1
Q
Indications
A
- Focal epilepsies, usually as an add-on to other drugs
- Neuropathic pain
- Gabapentin- migraine prophylaxis
- Pregabalin- generalised anxiety disorder
2
Q
Mechanism
A
Binds to voltage dependent calcium channels, preventing influx and therefore reduces neuronal excitability
3
Q
Important adverse effects
A
Drowsiness, dizziness and ataxia
4
Q
Important interactions
A
Use with benzos increases sedative effects
5
Q
How should gabapentin/pregabalin be prescribed?
A
Oral administration, starting with low dose
6
Q
How might gabapentin interfere with the results of a urine dipstick?
A
May cause a false +ve protein
