GABA and glycine Flashcards
gaba is the major transmitter in what area?
the brain.
glycine is the major transmitter in what area?
spinal cord.
what is becucline?
a competitive antagonist of GABA receptors.
what is strychnine?
an antagonist of glycine.
it inhibits glycine receptors.
case study - adulteration:
cocculus indicus multum and picrotoxin was added to beer to make it poorer quality.
picrotoxin causes seizures and respiratory paralysis in the body.
what effect does GABA have in the NS?
inhibitory.
how is GABA synthesised?
Glutamate - carboxyl group —-GAD—-> GABA.
what is GABA synthesised from?
glutamate.
is glutamate inhibitory or excitatory?
excitatory.
is GABA inhibitory or excitatory?
inhibitory.
which enzymes degrades GABA back into glutamate?
GABA-transaminase (GABA-T).
what is GABA-T deficiency called?
encephalopathy.
where is GABAa found?
postsynaptic mem.
where is GABAb found?
postsynaptic and presyn mem.
what type of receptor is GABAa?
ionotropic.