GABA Flashcards

1
Q

GABAa Benzodiazepine binding site drugs?

A

DIazepam, lorazepam. Used as anxiolytics, antidepressants, muscle relaxants.

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2
Q

GABAa GABA agonists?

A

GABA, muscimol.

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3
Q

GABAa GABA antagonists?

A

Bicuculline, gabazine.

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4
Q

GABAa Barbiturate/anaesthetic binding site drugs?

A

Pentobarbital, thiopental, propofol. Used as sedatives, antiepileptics, anaesthetics.

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5
Q

GABAa Channel blocking site drugs?

A

Picrotoxin, pentylenetetrazole. Convulsants.

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6
Q

GABAb agonists?

A

GABA, baclofen. spasticity (muscle spasms, rigidity) in MS and motor disorders. May also have sedative and anxiolytic effects.

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7
Q

GABAb antagonists?

A

2-hydroxy-saclofen, CGP55845A. Possibly use in epilepsy - block presynaptic GABAbR to prevent reduction of GABA release and increase synaptic inhibiton. May also be sedative.

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