G6PDH Deficiency Flashcards

1
Q

What enzyme is G6PDH?

A

Glucose-6-phosphate dehydrogenase

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2
Q

Where in G6PDH used? What does it do?

A

First enzyme in Pentose Phosphate Pathway

Converts Glucose6P to 6 phosphogluconate and recycles NADP–>NADPH

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3
Q

What are the oxidised and reduced forms of glutathione?

A

Oxidised- GSSG

Reduced- GSG

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4
Q

How is G6PDH deficiency managed?

A

No real treatment but avoid drugs and foods that cause oxidative stress eg. Beans

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5
Q

Why is G6PDH deficiency a problem?

A

No G6PDH- less NADP–>NADPH
TF activity of glutathione reductase and glutathione Peroxidase lowers
TF ROS’ accumulate

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6
Q

What is a clinical sign of G6PDH deficiency?

A

Heinz bodies

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