G Protein Messengers Flashcards
1
Q
alpha 1
A
Gq protein class
Fxn:
- Increase vascular smooth mm contraction
- increase pupillary dilator mm contraction (mydriasis)
- intestinal and bladder sphincter contraction
2
Q
alpha 2
A
Gi protein class Fxn: - decreased sympathetic outflow - decreased insulin release - decreased lipolysis - increased platelet aggregation - decreased aqueous humor production
3
Q
Beta 1
A
Gs protein Fxn: - increased HR - Increased contractility - increased renin release - increased lipolysis
4
Q
Beta 2
A
Gs protein Fxn: - vasodilation - bronchodilation - increased lipolysis - increased insulin release - decreased uterine tone - ciliary mm relaxation - increased aq. humor production
5
Q
Beta 3
A
Gs protein
Fxn:
increased lipolysis
increased thermogenesis in skeletal mm
6
Q
M1
A
Gq
Fxn:
CNS, enteric nervous system parasympathetics
7
Q
M2
A
Gi
Decreases HR and contractility of atria
8
Q
M3
A
Gq Fxn: increased exocrine gland secretions increased gut peristalsis increased bladder contraction bronchoconstriction increased pupillary sphincter mm contraction (miosis) ciliary mm contraction (accomodation)
9
Q
D1
A
Gs
Fxn:
relaxes renal vascular smooth mm
10
Q
D2
A
Gi
Fxn:
modulate transmitter release (esp. in brain)
11
Q
H1
A
Gq protein Fxn: increased nasal and bronchial mucus production increase vascular permeability contraction of bronchioles pruritis pain
12
Q
H2
A
Gs
increases gastric acid secretion via ECL cells acting on parietal cells
13
Q
V1
A
Gq protein
Fxn: increases vascular smooth mm contraction
14
Q
V2
A
Gs protein
Fxn:
increased water permeability and resorption in collecting tubules of kidneys (action is tied with ADH)
