Fungicides

Question 1

Sources for PCP

Answer 1

Cert applicators as wood preservative

-Licking cribbing wood tx w/PCP

Question 2

Physical and Chemical properties of PCP

Answer 2

Sol in oil, salt solub in H2O

• Not persistent in environm
• Irritant to MM, Resp, skin
• Older have dioxins are carcinogenic
• Moderate toxicity
• Licking, Cribbing

Question 3

Toxocokinetics of PCP

Answer 3

• Absorbed from GI
• Accumulates in fat 1st. Stays in fat for 1w
• L Met, U, exc

Question 4

MOA of PCP

Answer 4

• Uncouples ox. Phosphorylation -> PCP

- Overheating toxicosis

Question 5

CS/Lesions w/ PCP (acute and chronic)

Answer 5

-Met acid b/c lack of O2 (massive consumption of O2)
-↓ milk productions,
-May die quickly
-Acute : fast, fever, S+, ↑metabolism
-Chronic : ADR, wt. loss
Lesions: rapid rigor mortis, dark B+, skin irritation, HrKeratosis

Question 6

Analysis/Dx of PCP

Answer 6

BW: nothing specific
-Rapid rigor mortis
-Test K in dead, U+ & B+ in live
-Local irritation, pulm congest and liver
-Chronic: Hyperkeratosis and villous hrplasia of UB
Dx: Heat, dark B+, Met Ac.

Question 7

Ddx for PCP

Answer 7

Ddx: Heat stroke

• -Nitrate (brown B, no fever)
• -CO (bright B, no fever)
• -Pesticides (marked neuroma, auton signs)
• -Peracute infectious dz

Question 8

Tx/Px for PCP

Answer 8

Nothing specific
Tx: supportive
Prophylactic Ab+

Px good if survive >24h