Fungal infections Flashcards
ASPERGILLOSIS
LUNG FUNGAL INFECTION
voriconazole
Main skin infection - Tinea (ringworm)
What is the head,body,feet and nail alley an what is it treated with
- Tinea capitis - head
- Tinea corporis- body
- Tinea cruris - feet
- Tinea unguium /onychomycosis - nail
- Treat with topical anti fungal - terbinafine
- Nail region terbinafine or amorolfine nail lacquer
- Once weekly for up to one year
- Refer to Gp if under 18,more than 2 nails affected,diabetic or pregnant/breastfeeding
Anti fungal medication -
Fluconazole,itraconazole,ketoconazole+voriconazole
CAN CAUSE………..LESS RISK IN……..
- QT prolongation and hepatoxicity
- Less risk in fluconazole,more risk in ketoconazole,voriconazole and itraconazole
Itraconazole Bioavailibility improved by…
Carbonated drinks improves itraconazole bioavailability
Ketoconazole-
Chmp
- Life threatening hepatotoxicity - oral treatment suspended (CHMP Advice)
Voriconazole CONTRA
Phototoxicity occurs uncommonly - avoid sunlight exposure
Cryptococcosis:
amphotericin B
- Thrush: Vaginal
clotrimazole/fluconazole- resistant - itraconazole
ORAL TRUSH
Oral - nystatin/miconazole/fluconazole - resistant - itraconazole
SKIN AND NAIL INFECTION
Skin and nail infection- topical - systemic therapy (itraconazole,terbinafine)
Amphotericin B - can cause what?????? How long do you need to observe IV FOR??? What do you give apron precaution? Maintain what also?? What can occur with different formulations and overdose?
Can cause renal failure
- Anaphylaxis risk in Iv Amphotericin B - test done with 30 min observation
- Prophylactic antipyretic or hydrocortisone in patient with previous reaction
- Maintain same formulation between conventional, liposomal and lipid complex formulations - serious haram and fatal overdoses have occurred
-
-
Terbinafine -
hepatotoxic
