Functies van cytokinen (innate/adaptive IS) Flashcards

1
Q

IL-1

A

Koorts
Inductie acutefase-eiwitten (AFE) in lever

AFE: concentratie stijgt al in een vroeg stadium van ontsteking.

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2
Q

TNF-α

A

Inflammatie endotheel
Cachexie (verlies van spiermassa, gerelateerd aan ziekte)
Inductie van AFE in lever

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3
Q

IL-12

A

Stimuleert TH1-subset

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4
Q

IL-6

A

Gelijkaardig aan IL-1, maar minder krachtig

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5
Q

IFN-α en IFN-β

A

Interfereert met virusreplicatie (= anti-viraal)
Meer MHC-1
Activeert NK-cellen

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6
Q

IL-2

A

Proliferatie T- en B-cel
Activatie van NK-cellen

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7
Q

IL-4

A

Stimuleert TH2-subset
Stimuleert CSR naar IgE

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7
Q

IL-5

A

Stimuleert proliferatie centroblast (B-cel)

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8
Q

IFN-γ

A

Activeert macrofagen (en andere APC’s)
Meer MHC

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