Full Length #3 Flashcards
when the human body is going through starvation, you can generate glucose from:
- glycerol: can synthesize glucose via gluconeogenesis
- glycogen
- amino acids - can be used as substrated for gluconeogenesis
why is it that after several weeks of starvation, acetyl-CoA is primarily converted into ketone bodies?
- in starvation, large amouns of acetyl-CoA are generated by the degradation of fatty acids
- oxaloacetate concentration is depleted because it is used to synthesize glucose
- so although excess acetyl CoA is made during starvation, very little of it can be incorporated into the Krebs cycle because of low oxaloacetate concentrations
- instead the acetyl CoA is used to produce ketone bodies
increased expressivity
expressivity is the measure of the severity of a disease or the intensity of a phenotype
pentrance
a measure of the number of persons with an allele for a condition that display the condition
mortality
measure of the death rate in a population
morbidity
measure of illness
meissner’s corpuscle
tactile processing units in the skin
A patient who has gained 40 pounds in the past 3 months complains of fatigue to her physician. She found to have a goiter and a decreased metabolic rate. Based on this information, the patient most likely has a deficiency of
thyroxine
- is a thyroid hormone that plays an important role in regulating metabolism
- hasa goiter, which is an increase in mass of the thyroid
aldosterone
synthesized in the adrenal gland
- regulates electrolyte excretion and intravascular volume
- affects sodium, potassium, total fluid in the body, and blood pressure
estrogen
development of female secondary sexual characteristics
-breasts, endometrium, regulation of the menstural cycle
which of the following would be expected in methanol poisoning?
metabolic acidosis
-methanol produces formic acid, which will increase arterial [H+]
metabolic alkalosis
caused by the loss of an acid of the gain of a base
hypoventilation
results from metabolic alkalosiss in order to help the body retain acid
what do amino acids do during isoelectric focusing?
they migrate towards a pH near their pI
where is the anode in an amino acid?
the end of the gel with a low pH
where is the cathode in the amino acid?
the end with of the gel with a high pH
when an amino acid is at a pH about its pI, what will it do?
migrate towards the anode
when an amino acid is at a pH below its pI, what will it do?
migrate towards the cathode
silent mutation
if a codon is replaced with another condon but still codes for the same amino acid
ex: if the GAT codon is changed to GAC condon by replacing thymine with cytosine and the aspartic acid is still coded for
frameshirt mutation
an insertion or deletion
missense mutation
point mutation that results in a coding for a different amino acid
nonsense mutation
point mutation that results in a premature stop codon
lysosome
contain numerous enzymes which can break down proteins
also key in recycling
peroxisome
role in metabolism
- break down fatty acids to be used for forming membranes and fuel for respiration
- transfer hydrogen from compounds to oxygen to create hydrogen peroxide and then convert hydrogen peroxide into water
smooth endoplasmic reticulum
think of a factory!!
make cellular products like hormones and lipids
-distributes those products throughout the cell
founder effect
the evolutionary phenomenon where certain areas of the world show much higher frequency of particular alleles than other areas
bottleneck effect
random culling of a gene pool due to a natural disaster or overhunting
genetic drift
the likelihood that the gene pool of a small population will be significantly altered by random mutations
how is mitochondrial DNA passed down?
only through the mother’s egg since sperm cells do not have any organelles
all organelles in the embryonic cell come from who
the mother
persistent virus
needs to keep its host ccell alive and in good working order in order to survive
- do not kill their host cells bc they rely on them
- obligate parasites
the rate of an enzyme-catalyzed reaction can be influenced by which of the following?
temperature, pH, salinity
- activity of an enzyme is highly influenced by its environment
which of the following is a method of replication for epithelial cells?
mitosis
epithelial cells are identical to one another
epithelial cells are constantly shed from the body and have to be replaced
what levels of protein structure is characterized by alpha-helices and beta sheets?
secondary
primary structure
simply the sequence of amino acids in a polypeptide chain
secondary structure
local folded structure that form within a polypeptide
-alpha helix and beta pleated sheets
tertiary structure
3D structure of a polypeptide
quaternary structure
multiple polypeptide chains (subunits)
protein consisting of more than one amino acid chain
when the body is readying itself for action, what system is taking over?
sympathetic nervous system
- heart increase= more blood, more oxygen
- increases the blood supply to active muscle during exercise by dilating blood vessels in muscles while the blood vessels elsewhere in the body are constricted
what are the hypothalamic hormones
ADH corticotropin-releasing hormone gonadotropin releasing hormone GHRH oxytocin somatostatin thyrotopin releasing hormone
ADH
regulates water levels in the body
affects blood pressure and volume
Cortiocotropin-releasing hormone
stimulates anxiety
suppresses appetite
gonadotropin releasing hormone
stimulates release of hormones that act on testes and ovaries to initiate and maintain reproductive function
-increase in puberty to trigger sexual maturation
growth hormone releasing hormone
controls normal physical development in children, metabolism in adults
-increased by sleep, stress, exercise, and low blood glucose
oxytocin
synthesized by the hypothalamus and released via the posterior pituitary
controls aspects of some human behavior and key aspects of reproductive system
somatostatin
works in inhibit other hormones (growth and thyroid stimulating hormones)
-in the CNS
thyrotropin-releasing hormone
stimulates production of thyroid hormone
which cellular component has the most prominent role in the cleavage and contractility of the cytoplasm during such movement?
microfilaments