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SGU FTM 1 > FTM 1 Drugs > Flashcards

FTM 1 Drugs Flashcards

1
Q

Taxol

A

Anti-cancer

Prevents microtubule disassembly

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2
Q

Colchicine

A

Anti-cancer, Anti-gout
Prevents microtubule assembly
Fights inflammation

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3
Q

Vincristine/vinblastine (vinka alkaloids)

A

Anti-cancer

Prevent microtubule assembly

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4
Q

Phalloidin

A

Toxin

Disrupt actin function –> no cell movement

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5
Q

Cytochalasin

A

Toxin

Disrupts actin function –> no cell movement

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6
Q

Ciproflaxin

A

Antibiotic
Inhibit DNA gyrase
-respiratory infection

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7
Q

Novabiocin

A

Antibiotic
inhibit DNA gyrase
-staph infection, MRSA

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8
Q

Nalidixic Acid

A

Antibiotic
inhibit DNA gyrse
-respiratory infection, uti

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9
Q

Azidothymidine (AZT) Zidovudine

A

Anti-viral

disrupts DNA elongation–>base lacks 3’OH

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10
Q

Didanosine (ddl)

A

Anti-viral

disrupts DNA elongation–>base lacks 3’OH

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11
Q

Acylovir

A

Anti-viral
Disrupt DNA elongation –>base lacks 3’OH
-uses viral kinase
-herpes

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12
Q

Tenofovir

A

Anti-viral

disrupt DNA elongation–> competes w/dATP

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13
Q

Adenine Arabinoside (AraA)

A

Anti-viral

3’OH=stereo restraint –> chain termination

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14
Q

Cytoscine arabinoside (araC)

A

Anti-cancer

3’OH=stereo restraint –> chain termination

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15
Q

Camptothecin

A

Anti-cancer

Binds and inhibits topoisomerase I

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16
Q

Etoposide

A

Anti-cancer

inhibits topoisomerase II

17
Q

Actinomycin D

A

Anti-cancer

inhibits RNA poly both prokaryotes and eukaryotes

18
Q

Rifampin

A

Antibiotic

inhibits RNA poly –> inhibit initiation of transcription

19
Q

a-Amanitin (mushroom)

A

Toxin

Inhibit RNA pol II–>hepatotoxicity–>death

20
Q

Phalloidin

A

Toxin

inhibit RNA pol II–> not absorbed by GI tract –> not toxic by oral intake

21
Q

Streptomycin

A

Antibiotic

Blocks initiation: prevents assembly of ribosome by binding to 30s

22
Q

Tetracycline

A

Antibiotic

Blocks elongation: prevents aminoacyl-tRNA access to A site

23
Q

Erythromycin

A

Antibiotic

Blocks elongation: blocks ribosome translocation by binding to 50s

24
Q

Chloramphenicol

A

Antibiotic

Blocks elongation: prevents peptidyl transferase activity in prokaryotes

25
Q

Cycloheximide

A

Antibiotic

Blocks elongation: prevents peptidyl transferase activity in eukaryotes

26
Q

Puromycin

A

Antibiotic

Blocks elongation: premature termination in translation by bearing structural resemblance to aminoacyl-tRNA

27
Q

Diphtheria

A

Toxin

inactivates EF-2–>prevent translocation

28
Q

Mycophenolic Acid

A

Immunosuppressive

inhibits conversion of IMP to GMP

29
Q

Sulfonamide/ sulfa drugs

A

Antibiotic

inhibit folate synthesis

30
Q

Trimethoprim

A

Antibiotic

inhibit bacterial dihydrofolate

31
Q

Methotrexate

A

Anti-cancer

inhibit eukaryotic dihydrofolate reductase

32
Q

Hydroxyurea

A

Anti-cancer

inhibits ribonucleotide reductase

33
Q

Allopurinol

A

Anti-gout

inhibits xanthine oxidase

34
Q

5’ Fluorouracil

A

Anti-cancer

inhibits thidiylate synthase

SGU FTM 1 (4 decks)

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