FTD

Question 1

pathology in FTD

Answer 1

TDP 43 protein

tau

Question 2

percent with Fam Hx

Answer 2

40%

Question 3

types of FTLD (lobar egeneration

Answer 3

behavioural variant of FTD
language variants ( semantic aphasia, PPA, primary non-fluent apahasia), Pick's dis (pathological dx, corticobasal syndrom, progressive supranuclear palsy, FTD with ALS or with PD)

Question 4

parkinsons plus DO

Answer 4

i. corticobasilar dementia falls into a class of “Parkinson’s-plus disorders”, or “atypical Parkinsonism”
1. progressive supranuclear palsy (PSP): early falls (falls occur late in Parkinson’s disease); low blink rates, failure of downward saccadic movements
2. corticobasilar ganglionic degeneration (CBD): resembles PSP, but with unilateral (rather than bilateral) difficulties; experience “alien limb” phenomena; rigidity is more problematic; CBD does not respond to l-DOPA; language is impaired in 50% of cases
3. Binswanger’s disease: rigidity and slowness similar to Parkinson’s, but also have corticospinal tract signs, and spastic bulbar palsy
4. normal pressure hydrocephalus (NPH): altered mentation, gait disturbances, and sphincter disturbances; ventricles are dilated but LP pressure is normal
5. multiple system atrophy: used to be called striato-nigral degeneration and olivopontocerebellar atrophy
32) Binswanger’s disease involves: [MIKE]

Question 5

types of language variant FTD

Answer 5

progressive non fluent apahasia: looks like a broc a sort of, naming then grammar then comprehention, behaviour affected late.

Semantic: looks like a wernicke sor tif. comprehention firsts, normal fluency, harder to name categories than things that start with a letter, lose facts and concepts but episodic memory initially Ok

logopenic, broader imparment between the above two. slow speech, episodic memory also impaired.