Frontotemporal Dementia (FTD) Flashcards

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1
Q

How common

A

4th most common dementia

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2
Q

Onset

A

Between 50-60 years old
Mean onset is 59

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3
Q

Risk factors

A

Genetic factors
Presence of ubiquitin

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4
Q

Pathology

A

Inclusion bodies
Regional cortical atrophy
Degeneration of some aspect of the frontal/temporal lobes
Behavioral Variant FTD (bvFTD)
Primary progressive aphasia (PPA) or language variant FTD

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5
Q

Inclusion bodies

A

Accumulations of protein inside cells that are markers of disease
Tau inclusions
Ubiquitin inclusions

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6
Q

Regional cortical atrophy

A

Predominantly in frontal and/or temporal lobes

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7
Q

Behavioral Variant FTD (bvFTD)

A

Atrophy, neuronal loss of frontal cortex
Tauopathy with tau-positive inclusion

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8
Q

Primary progressive aphasia (PPA) or language variant FTD

A

Nonfluent/agrammatic PPA
Semantic variant PPA
Logopenic PPA

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9
Q

Nonfluent/agrammatic PPA

A

Frontal and basal ganglia atrophy (tau)
Characterized by speech and grammar difficulties
Knowledge of word meaning are intact

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10
Q

Semantic variant PPA

A

Temporal atrophy (ubiquitin positive)
Loss of comprehension with fluent speech
Difficulties understanding what others are saying and recalling the meaning of words

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11
Q

Logopenic PPA

A

Temporal and parietal atrophy (usually AD pathology; plaques and tangles)
Word-finding difficulties

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12
Q

Frontal/Behavioral Variant FTD - Behavioral presentation

A

Personality changes consistent with frontal systems dysfunction
Loss of social awareness, apathy, social withdrawal, decreased personal hygiene, social disinhibition, impulsivity, perseveration
Decreased insight

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13
Q

Frontal/Behavioral Variant FTD - Neuropsychological performance

A

Executive dysfunction greater than memory dysfunction
Language deficits (fluency, naming)
Intact visuospatial skills and orientation

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