French DD I

Question 1

Which NSAID is prothrombotic?

Answer 1

Celecoxib

Question 2

Which is the only NSAID with anti-platelet at low doses?

Answer 2

Aspirin

Question 3

Which NSAID is the only non-inflammatory one,

Answer 3

Acetominophin

Question 4

What turns Cell membrane phospholipid to Arachadonic Acid

Answer 4

phospholipase A

Question 5

Which prostaglandins have pain sensitization effect?

Answer 5

PGI2 and PGE2

Question 6

Which prostaglandins have fever effects?

Answer 6

PGE2

Question 7

Which prostaglandins have pain sensitization effect?

Answer 7

PGD2

Question 8

Glucocorticoids inhibit which cox?

Answer 8

Cox2

Question 9

Cox 1 and 2 relationship w/ Prostacyclin relationship w/ prostaglandin

Answer 9

inhibiting cox 2 - inhibits prostacyclin

inhibiting cox 1- inhibit txn which is a prostaglandin

Question 10

Aspirin effects at low medium and high dose

Answer 10

low: antiplatelet
medium: analgesic and antipyretic
high: anti infammatory

Question 11

Aspirin effects on MI

Answer 11

secondary prevention of MI

Question 12

Which syndrome is associated w/ severe aspirin side effects?

Answer 12

Reyes syndrome

Question 13

Tinnitus is associated w/ which NSAID intoxication?

Answer 13

Aspirin

Question 14

Name of a tNSAID that has analgesic effects

Answer 14

Ketolorac in IM/IV formula

Question 15

Benefits of Celecoxib outweigh risk in?

Answer 15

Pts who cannot tolerate high dose NSAIDS due to GI side effect

Question 16

Risk may outweigh benefits for celecoxib in?

Answer 16

Pts w. underlying cardiovascular disease

Question 17

side effect of alkylating agent

Answer 17

hematopoietic toxicity
carcinogenesis
alepecia
GI Toxicity
gonadal toxicity

Question 18

antimetabolites

blocks what?

Answer 18

Methotrexate
blocks DHFR (required for purine synthesis) - blocks DNA synthesisT

5’FU
-block DNA sythesis

Question 19

MTX toxicity

Answer 19

myelosuppression
renal toxicity
hepatotoxicity
neuro
terato
GI - all toxicity

Question 20

Topoisomerase toxicity

Answer 20

cardiotoxicity

secondary malignancies

Question 21

antimicrotubule aka? Toxicity?

Answer 21

“vinca alkaloids”
neurotoxicity - cause by vincristine
neutropenia - vinblastine

Question 22

Antimicrotubule agents toxicity

Answer 22

“taxanes”
myelosuppression - neutropenia
peripheral neuropathy
alopecia