French DD I Flashcards
Which NSAID is prothrombotic?
Celecoxib
Which is the only NSAID with anti-platelet at low doses?
Aspirin
Which NSAID is the only non-inflammatory one,
Acetominophin
What turns Cell membrane phospholipid to Arachadonic Acid
phospholipase A
Which prostaglandins have pain sensitization effect?
PGI2 and PGE2
Which prostaglandins have fever effects?
PGE2
Which prostaglandins have pain sensitization effect?
PGD2
Glucocorticoids inhibit which cox?
Cox2
Cox 1 and 2 relationship w/ Prostacyclin relationship w/ prostaglandin
inhibiting cox 2 - inhibits prostacyclin
inhibiting cox 1- inhibit txn which is a prostaglandin
Aspirin effects at low medium and high dose
low: antiplatelet
medium: analgesic and antipyretic
high: anti infammatory
Aspirin effects on MI
secondary prevention of MI
Which syndrome is associated w/ severe aspirin side effects?
Reyes syndrome
Tinnitus is associated w/ which NSAID intoxication?
Aspirin
Name of a tNSAID that has analgesic effects
Ketolorac in IM/IV formula
Benefits of Celecoxib outweigh risk in?
Pts who cannot tolerate high dose NSAIDS due to GI side effect
Risk may outweigh benefits for celecoxib in?
Pts w. underlying cardiovascular disease
side effect of alkylating agent
hematopoietic toxicity carcinogenesis alepecia GI Toxicity gonadal toxicity
antimetabolites
blocks what?
Methotrexate blocks DHFR (required for purine synthesis) - blocks DNA synthesisT
5’FU
-block DNA sythesis
MTX toxicity
myelosuppression renal toxicity hepatotoxicity neuro terato GI - all toxicity
Topoisomerase toxicity
cardiotoxicity
secondary malignancies
antimicrotubule aka? Toxicity?
“vinca alkaloids”
neurotoxicity - cause by vincristine
neutropenia - vinblastine
Antimicrotubule agents toxicity
“taxanes”
myelosuppression - neutropenia
peripheral neuropathy
alopecia
