BL I

Question 1

Salk

Answer 1

Killed polio vaccine, given IV to activate IgG

Question 2

Sabin

Answer 2

Live Polio vaccine, given orally to activate IgA. Banned because it spread to immunodeficient children.

Question 3

Ankylosing Spondylitis

Answer 3

Linked with HLA-B27 gene. Causes inflammation of joint insertions.

Question 4

Mitogens

Answer 4

PHA and PWW bind CD3 (expressed in all T-cells) to cause mass mitosis.

Question 5

Treg

Answer 5

Uses IL-10 (FoxP3,TGF-b) to regulate T-helper cells and inactivate them.

Question 6

Tfh

Answer 6

Activates B-cell in the follicles of the lymph node and allows IgM- to change to a different class.

Question 7

CTL

Answer 7

Kills MHCI expressing cells, and activated by IL-2 from Th1

Question 8

Th2

Answer 8

Expresses IL-4 activating M2/alternate macrophages, more common in healing. Activates b-cells and eosinophils.

Question 9

Th17

Answer 9

IL-17 responds to extracellular bacteria and yeast

Question 10

Th1

Answer 10

Expressed IFN-g to activate M1/classical/angry macrophages which are very destructive, and IL-2 to activate CTL

Question 11

B-Cell Maturation

Answer 11

Pre (mu chain)- Pro (IgM in cytoplasm)- Immature (sIgM), if passes selection test, then mature (sIgM sIgD).