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A-PARA CNS > Free linivg amoeba > Flashcards

Free linivg amoeba Flashcards

1
Q

بسم الله الرحمن الرحيم
__________________
Mention free lving aboema causing Enceplaiits ?

A

-Neglaria folweri
-Acanthabmoeba

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2
Q

بسم الله الرحمن الرحيم
__________________
Mention free lving aboema causing Enceplaiits ?

A

-Neglaria folweri
-Acanthabmoeba
facultative parasites

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3
Q

Intro
free linving amoeba:-
Inhabit ,,,,,,,and,,,,,,,,,
No ,,,,,,, no ,,,,,,,no,,,,,,,,,
NO human to human transmission
No relation with saniatation

A

Soil and water

no definitive host no Resvoir no Vector

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4
Q

Mention morphology of Neglaria Fowleri ?

A

2 Stages Trophozoites+cyst
3 froms :
Ameboid trophozite
Flagellate Trophozite
Cyst

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5
Q

Invective stage of Neglarai fowelri ? >

A

Ameboid tropohzoites

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6
Q

Invective stage of Neglarai fowelri ? >

A

Ameboid tropohzoites

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7
Q

Diagnostic Stage of Neglaria fwoelir?

A

Ameboid trophozoites
dividing form
only form found in tissue and CSF

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8
Q

Mention size and shape of Ameboid trophozite of NF

A

Size 7-20 micro
Shape :
broad end with peusdopodium called lopopodia
Narrow end

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9
Q

Describe nucleous and Cytoplasm of Ambeoid cyst of Neglaria fowlair ?

A

Nucelus : large central vesicular with Central Karyosome + no peripheral chromatin
Cytoplasm : Clear ectoplasm
+ Granular endoplasm with contractile vacuoles

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10
Q

What is PAM what is causing it?

A

Primary Ambeoic meningocencephalitis
By Neglaria Fowaleri !

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11
Q

Flagellated trophozoites is
,,,,,,,and…..and………
formed when amobeis stage is exposed to change in ,,,,,?
It changes to ameboid form when there is unfavrable conditions in water before ,,,,?

A

Temporary , non dividing , nonfeeding
______________________
water ionization
___________________
Encysation

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12
Q

Describe shape and nuscleus of Flagellate trophozoites

A

It pear like with 2 flagellats
Nulceus :
large vesicular with central karyosome and no peripheral chrmoatins

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13
Q

Resistant stage of Neglaria Fowlei?

A

Cyst stage
7-15 micro in size

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14
Q

Why cyst cannot be seen in sepicemins ?
and describe its shape + Nucelus

A

Because the course of the disease is Rapid and fatal even before trophozite encyst
shape : spherical with dobule wall with pore
Nucelus with single Nuceloulus

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15
Q

Habitiat of N,fowleri ?

A

Soil and infected water
Human brain

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16
Q

Mode of transmisson of PAM ?
Primary amboeic menigionencephalitis

A

1-Swimming and diving in infected water containing Amboeid trophozoites of N.fowleri
through nose to cribriform plate and olfactory nerve to brain cause acute suppuraive inflammation.
2-Inhalation of aerosols containing the Trophozites

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17
Q

PAM caused but secnodary casued by?

A

PAM by N.fwoleir
Secondary entamboeica histolytica

18
Q

Pathogenisis of nagelria fowleri describe

A

Enter through nose to
cribirofom plate to
olfactory nerve
to brain and meiniges
casuing acute suppurative meningoencephlaitis
in perivascular spaces

19
Q

N,fowleeri has 2 ways to kill cells how ?

A

1-Trogocytosis : Ingestion of cytoplasm
2-Contact dependent lysis=acute necrotizing meninigoencephalitis

20
Q

C/P OF Naglarie fowelri ?
commonly affecting, ,,,,and,,,,
IP = …TO….
ONSET= ACUTE = ?

A

Chidlren and young adults
___________________
2-5 days
__________________
Tase and smell loss
Headache +Fever
Increased ICP
nECK rgigidit
Motor and sensory changes
Coma and death

21
Q

How to diagnose Naglaria fowleir?

A

History
CSF
Culture
CBC
PCR

22
Q

History for diagnosis of Naglareira fowleir?

A

Swimmming in infected water
Taste and smell changes differetiating it from ? Bacterial meningits

23
Q

Lumbar puncture in PAM reveal ?

A

Ameboid trophoziote
the CSF cc ?
Cloudy + Purulent + Blood tinged + Tension
with Increased Polymorpnucelar cells + lymphocytes + proetin
and Decreased glucose

24
Q

Culture of Nagleria FOwlei?

A

In non nutreint agar with gram negativ bacilli culture before

25
Q

CBC IN nagleria why?

A

To detect polymorphonueclarcells increase so differentiaed form viral encephalitis

26
Q

Treatment and prevention OF PAM
DESCRIBE

A

ORALLY
+ Amphoteriin B IV
_____________________
Avoid swimming in infected water
Biguandies + bugacil to swimming pools

27
Q

GAE !
granulomatous ameobic encephalitis caused by?

A

Acanthameoba

28
Q

GAE !
granulomatous ameobic encephalitis caused by?

A

Acanthameoba or can cause
amobic Keratitis
it is Opportuistic
!!!!!

29
Q

حتي إذا استيئس الرسل وظنوا أنهم قد كُذِبوا جاءهم نصرنا فنجي من نشاء ولا يُرَد بأسنا عن القوم المجرمين

A
30
Q

Mention Acanthamboea forms

A

Trophozite and cyst both
are diagnostic and infective

31
Q

Trophozite of acantheabomba is
,,,,,,AND,,,,,,STAGE?
SIZE :…TO…..
SHAPE:……….
Nucleus:?
cytoplasm ?

A

Infective and diagnosti
22-30 micro
Irregualr with spine pseudopodia
nucelus single with central karyosoma and no peripheral chromatin
Cytopalsm contians single Contractile vacuole

32
Q

Cyst form of acantheamboeba is
,,,,and,,,,,,stage
size?
shape?
Nucleus??
disperesed by ? to ?
Acantheamboea cysts can be found in ,,,,,, in contrast to ?

A

Infective and diagnostic stage
size =18 micro
shape ? Rounded in shape with double wall
the outer wall is wrinkeled
and the inner wall is polyhedral
Nucleus is single
Dispetred by wind to contaminate environmetn
Can be found in human tissue in contrast to Nagelaria

33
Q

habitat of acantheaombea?

A

Is water soil and contact lens or dialysis machine
_____________
in human
Brain + eye
Lungs
Genitourinary + Skin

34
Q

Mode of acanthamboeba?

A

Through corneal abraisons
Trough nasal passages when inhalation aeroslos of cysts and trophozoites
Through Skin abraisons
Through Genitourinary tracts

35
Q

Pathogenisis of GAE
granulomatius amboeci encephlaits

A

in immunocomprised
or in healhty in organs away immunity as cornea
_____________________
Via blood to brain with slow invasion of brain tissue causing chronic granulomatous inflammation and foci of granuloma with Hge and Necrois via 2 methods ?
Torgocytosis eating cytoplasm
Contact depedntn lysis

36
Q

Clincal presenation of Granulomatous abomeic enceplatiics ?

A

Gradual onset! weeks for monts is the incubation
1-symptoms and sign of increased icp ?
Headche fever nausea vomiting
Sensory and motor changes
skin lesios as ulcerative nodules
_______________________
Amboebic Keratitis :
In using OF contaminaed contact lens causing abrasions of eye :
Corneal ulcer
Congested Conjunctive
Corneal opacity and blindeness
___________________________________
Dissaminated:
Skin ulcers and nodules in body may reach ear and eye , Genioturinaty tract
and internal organs

37
Q

Diagnosis of GAE

A

Clinical : Contact eye lenses
_____________________
Lab investiagtions :-
1-CSF
2-Culture
5-brain biopsy
3-Corneal scarppin
4-skin biopsy
searching for what
Trophozoite and Cysts of Acanthamobeba

38
Q

For treatments of GAE AND Amobic keratitis ?

A

GAE:
Sulfadiazine + Ketoconazole
_______________________
Amoebic Keratitis :-
Chlor-hexadine
Polyhexamethylene-Biguanide
________________________

39
Q

PREVENTION OF AMBOCI KEARTIS THEN GAE?

A

wearing clean Conatct lenses
Avoiding waring lenses during swimming

40
Q

” الله نزل أحسن الحديث كتابا متشابها مثاني تقشعر منه جلود الذين يخشون ربهم “!
…..

A

ثم تلين جلودهم وقلوبهم إلي ذكر الله ذلك هدي الله يهدي به من يشاء “
:)

A-PARA CNS (2 decks)

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