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Haematology > FRACP questions > Flashcards

FRACP questions Flashcards

1
Q

Which cytogenetic abnormality has the best prognosis in Acute myelogenous leukemia?

A

t(15:17)

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2
Q

Strongest adverse clinical predictor in AML

A

Age age age!

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3
Q

What is the single most important test in determining prognosis in AML?

A

Cytogenetics!

deletions on chromosome 5 or 7 = bad!

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4
Q

What is the most common genetic abnormality in AML?

A

FLT3.

FLT3-ITD +ve  carries worst prognosis

NPM1 good

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5
Q

Bridging anticoagulation in patients with CHADS2 2 or 3?

A

Nahhh not needed if CHADS2 2 to 3.

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6
Q

AML treatments

A
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7
Q

Differentation syndrome in APML patients during induction therapy

A
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8
Q

Indications for treatment in CLL

A
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9
Q

Prognostic factors in CLL

A
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10
Q

Venetoclax has recetnly been proven to be useful in the treatment of which condition?

A
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11
Q

Ibrutinib

A

Targeting B cell malignancies.

Orally administeredm selective and covalent inhibitor of the enzye Bruton’s tyrosine kinase and has been approved for the treatment of:

  • mantle cell lymphoma
  • CLL
  • Waldenstrom’s macroglobuinema
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12
Q

Philadelphia chromosome in CML

A

Translocation between the long arm of chromosome 9 and 22 = BCR-ABL fusion –> codes for a protein which has tyrosine kinase activity in excess of normal

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13
Q

Myelodysplasia is at risk of transformation into which type of malignancy?

A

AML

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14
Q

Which agent is helpful in treatment of myelodysplastic syndrome with chromosome 5q syndrome?

A

Lenalidomide

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15
Q

CML prognostic risk score

A

HASFORD prognostic score:

  • Age
  • Platelets
  • Spleen size
  • Basophils
  • Eosinophils
  • Blasts
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16
Q

Features of complete haematological response in the treatment of CML

A
    • complete normalisation of peripheral blood
    • no immature cells in peripheral blood
    • No signs and symptoms of disease including disappearance of splenomegaly
    • no philadelphia chromosome
17
Q

What is the main mechanism of imatinib resistance in CML?

A

Mutations of BCR-ABLkinase domain

Haematology (4 decks)

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