FRACP questions Flashcards
Which cytogenetic abnormality has the best prognosis in Acute myelogenous leukemia?
t(15:17)
Strongest adverse clinical predictor in AML
Age age age!
What is the single most important test in determining prognosis in AML?
Cytogenetics!
deletions on chromosome 5 or 7 = bad!
What is the most common genetic abnormality in AML?
FLT3.
FLT3-ITD +ve carries worst prognosis
NPM1 good
Bridging anticoagulation in patients with CHADS2 2 or 3?
Nahhh not needed if CHADS2 2 to 3.
AML treatments
Differentation syndrome in APML patients during induction therapy
Indications for treatment in CLL
Prognostic factors in CLL
Venetoclax has recetnly been proven to be useful in the treatment of which condition?
Ibrutinib
Targeting B cell malignancies.
Orally administeredm selective and covalent inhibitor of the enzye Bruton’s tyrosine kinase and has been approved for the treatment of:
- mantle cell lymphoma
- CLL
- Waldenstrom’s macroglobuinema
Philadelphia chromosome in CML
Translocation between the long arm of chromosome 9 and 22 = BCR-ABL fusion –> codes for a protein which has tyrosine kinase activity in excess of normal
Myelodysplasia is at risk of transformation into which type of malignancy?
AML
Which agent is helpful in treatment of myelodysplastic syndrome with chromosome 5q syndrome?
Lenalidomide
CML prognostic risk score
HASFORD prognostic score:
- Age
- Platelets
- Spleen size
- Basophils
- Eosinophils
- Blasts
Features of complete haematological response in the treatment of CML
- complete normalisation of peripheral blood
- no immature cells in peripheral blood
- No signs and symptoms of disease including disappearance of splenomegaly
- no philadelphia chromosome
What is the main mechanism of imatinib resistance in CML?
Mutations of BCR-ABLkinase domain
