FPE MED18 Flashcards
Features of complete heart block (4)
Syncope
Heart failure
Wide pulse pressure
Bradycardia
Types of heart block and explain them (4)
First degree – prolonged PR interval
Second degree type 1: progressive prolongation and then drop.
Second degree type 2: consistently prolonged PR interval and then drop.
Third degree: no association between the p waves and the QRS complex.
Management of heart block (4)
Atropine
Transcutaneous pacing
Transvenous pacing.
Permanent implantable pacemaker.
Define orthostatic hypotension
A drop in BP (usually >20/10 mm Hg) within three minutes of standing.
“3, 2, 1 rule”
3 minutes, 20 drop in systolic, 10 drop in diastolic.
List 4 medications that can cause falls
Acetylcholinesterase inhibitors
Antiarrhythmics
Anticholinergics
Antidepressant
Antihistamines
Antihypertensives
Antipsychotics
H2 blockers
Hypoglycaemics
Laxatives (in excess)
NSAIDs
Opioids
Polypharmacy
PPIs
Sedative hypnotics
Steroids
List 4 other causes of loss of consciousness (apart from orthostatic hypotension)
Aortic stenosis
Dehydration
Hypoglycaemia
TIA/Stroke
Seizures
List 4 malignanct causes of cervical lymphadenopathy
Lymphoma
Leukaemia
Nasopharyngeal carcinoma – SSC
Gastric cancer (supraclavicular)
List 4 causes of lumps in the neck (apart from lymphoma)
Branchial cyst
Cystic hygroma
Thyroglossal cyst
Dermoid cyst
Lipoma
What are 2 B symptoms
> 10% weight loss in the past 6 months
Night sweats
Temperature >38 degree celsius
Describe this type of cell and describe it’s structure.
Reed-sternberg cell - large, abnormal lymphocytes (a type of white blood cell) that may contain more than one nucleus.
Mirror image cell
Describe the staging of lymphoma and what additional tests must be done prior.
Ann Arbor staging (describe each stage)
CT, MRI, PET, Lymph node biopsy, LDH.
What is an Odd’s ratio?
The odds ratio tells us how much higher the odds of exposure are among case-patients than among controls.
AD/CB
List 2 immediate and 2 delayed reactions of blood transfusions
2 immediate: Anaphylaxis, acute haemolytic transfusion reaction, Acute GVHD, TACO, TRALI
2 delayed: Chronic GVHD and delayed haemolytic transfusion reaction
List 4 types of prolapses
Uterocecole
Cystourethrocele
Vault prolapse
Uterine prolapse
Rectocele
Cystocele
List 3 conservative and 3 non-conservative treatments for prolapses.
Conservative: weight loss, vaginal oestrogen cream, physiotherapy, vaginal pessaries.
Surgical: hysterectomy, mesh repair, posterior colporrhaphy (Rectocele)
Name two examinations that must be completed when examining for prolapses.
Sims speculum examination
Cough test - to assess full descent of the prolapse
Dorsal and left lateral position to examine prolapse
4 symptoms of prolapses
Heaviness in the abdomen
Urinary incontinence - frequency, urgengy, retention
Bowel incontinence - constipation
Altered sexual experience
Investigations for someone presenting with incontinence
3 day bladder diary
Urine dipstick - to rule out infection
Urodynamic studies
List four signs of Parkinson’s
Rigidity
Bradykinesia/Akinesia
Shuffling gait
Tremor
Why would you use L-dopa and carbidopa instead of dopamine?
Carbidopa prevents levodopa being broken down in the peripheral nervous system.
Why do patients with Parkinson’s get choreiform movements?
Due to fluctuating levels of dopamine and continued loss of dopamine producing cells
Describe the pathophysiology of Parkinson’s.
Degeneration of dopamine neurons is particularly evident in a part of the substantia nigra called the pars compacta. Significantly, the loss of dopamine in the par’s compacta increases the overall excitatory drive in the basal ganglia,* disrupting voluntary motor control and causing the characteristic symptoms of PD.
List 4 types of Parkinson’s medications and their mechanisms of action.
L-dopa - converted into dopamine in the brain
MAO-B inhibitors - sellegiline
COMT inhibitors - Tolcapone
Amantadine - MOA unknown.
Dopamine agonists - bromocriptine
Antimuscarinics - procyclidine
Name 2 tests used for the screening of Down’s syndrome and the other conditions they test for.
Combined screening and quadrople testing
Patau’s (trisomy 13) and Edwards (trisomy 18)
4 features of a good screening test
Inexpensive
Sensitive
Not harmful
Easy to administer