Formulation Flashcards
What is formulation
Process by which the active ingredient in a medication is combined with other ingredients to form the final medicinal product
Why should we study formulation
The form of drugs are being changed everyday and there can be many consequences.
What can effect the form of a drug given
Patient:
-Illness
-comorbidities
-preference
Drug:
Stability
Shelf life
Therapeutic:
Bioavailability
Clinical efficacy
What form can drugs come from:
Tablets
- Compressed/multiple compressed
- Chewable
- Dispersible
- sugar coated
- film coated
- gelatine coated
- Buccal
- enteric coated
What forms can drugs come in
Tablets/capsules
Extended release preparation e.g. (MUPs)
Liquids
Semi solid
What form can Liquid drugs come in
Monophasic (solutions, syrups, elixirs, linctuses)
Polyphasic (Suspension, Emulsions, Collodions)
What form do semi solid drugs come in
Creams, gel ointments, pastes, inhalation, patches, aerosol
What does medication consist of
Medication= Active + Excipients
Excipients
Constituents of the medication that are administered or taken by the patient other than the active drug substance
Examples of Excipients: Binder
Binder (gelatin)
Use:
Binds to give form and strength to tablet
Examples of Excipients : Diluents
Diluents (Dextrin/glucose, Silicate/calcium salts)
use:
Provide bulk
Excipients: disintegrants
Disintegrants:
Starch/alginates
Use:
Swell up in water and aid dispersion of drug in GI tract
Excipient: Glidants
Glidants
(silica compounds)
use:
Aid in fluidity of powders during manufacture
Excipient: Preservatives
Preservatives (Alcohol/ benzoic acid)
Use:
Antimicrobial activity/ may also act as solvents
Excipient:Coatings
Coatings (Cellulose)
use:
Aid in swallowing, mask taste and odour, may delay disintegration, environmental protection.
