Formula's Flashcards
Dalton’s law
Ptotal = P1 + P2
Boyle’s law
P1V1 = P2V2
Henry’s law
Concentration = P (soluble)
Fick’s law of diffusion
Vgas = Area/Thickness * diffusion constant * (P1 - P2)
Diffusion constant
D = soluble/molecular weight
Starling-Landis equation
Jv = Lp * A * [(Pmv - Pint) - sigma(d) (pi(p) - pi(int))]
Jv = microvascular filtration rate
Lp = hydraulic conductivity (measure water permeability)
A = surface area
P mv = hydrostatic pressure microvessels
P int = hydrostatic pressure interstitium
sigma (d) = osmotic reflection coefficient
pi (p) = colloid osmotic pressure plasma
pi (int) = colloid osmotic pressure interstitium
Ohm’s law
Ql = (Pint + Ppump - Psv)/Rl
Ql = lymph flow
Pint = hydrostatic pressure interstitium
P pump = effective driving pressure generated by cyclic intrinsic contraction and extrinsic compression of lymphatic vessels
Psv = systemic venous pressure
Rl = resistance to lymph flow
F = delta P/ R
R = resistance
Oxygen delivery index (DO2) (2)
1) CO * CaO2
CO = cardiac output
CaO2 = arterial oxygen content
2) CI (ml/kg/min) * CaO2/100
Arterial oxygen content (CaO2)
CaO2 = [1.34 * SaO2 * Hb] + [PaO2 * 0,003]
SaO2 = saturation
Hb = hemoglobin (g/dL)
P (A) O2 (alveolar oxygen pressure) - shortened
P (A) O2 = 150 - PaCO2
Oxygenation index (OI)
OI = MAP * FiO2 * 100/PaO2
Oxygen saturation index (OSI)
OSI = MAP * FiO2 * 100/SpO2
P (A) O2 (alveolar oxygen pressure) - full version
P (A) O2 = (Pbar - Ph2o) * FiO2 - (PaCO2/RQ)
Pbar = atmospheric pressure
Ph2o = partial pressure of water
RQ = respiratory quotient (0.8)
Venous admixture expressed as percent of cardiac output (Qs/Qt)
Qs/Qt = (CcO2 - CaO2)/(CcO2 - CvO2)
Qs = shunt fraction
Qt = cardiac output
CcO2 = oxygen content of end-capillary blood
CaO2 = oxygen content of arterial blood
CvO2 = oxygen content of mixed venous blood
Minute ventilation (Ve)
Ve = Vt * RR
Vt = Tidal volume
RR = respiratory rate
Tidal volume (Vt)
Vt = Vd + Va
Vd = dead space ventilation
Va = alveolar ventilation
Alveolar ventilation (Va)
Va = Ve - Vd
Ve = minute ventilation
Vd = dead space ventilation
Bohr’s equation (4)
1) Vt * Fe = Va * Fa
Vt = tidal volume
Fe = CO2 in exhaled gas
Va = alveolar volume
Fa = CO2 in alveolus
2) Vd/Vt = (Fa - Fe)/Fa
Vd = dead volume
3) Vd/Vt = (P(A)CO2 - PeCO2)/P(A)CO2
P(A)CO2 = partial pressure of CO2 in alveolus
PeCO2 = Partial pressure of CO2 in expired air
4) Vd/Vt = (PaCO2 - PeCO2)/PaCo2
PaCO2 = arterial partial pressure of CO2
Alveolar ventilation equation
P (A) CO2 = directly proportional to ( vCO2 /V(A)) * k
vCO2 = amount of CO2 produced by metabolism
V(A) = alveolar ventilation
k = 0,863
Pressure gradient between RA and RV in systole
pressure gradient = 4 velocity [m/s]2
Flow rate in high flow
Flow rate = Patient’s minute volume = respiratory rate * tidal volume
Equation of Motion
Pvent + Pmuscles = Elastance * volume + resistance * flow
Pvent = pressure generated by ventilator
Pmuscles = pressure generated by inspiratory muscles
Serum osmolality
Osmolality = 2 [Na] + (BUN/2.8) + (glucose/18)
BUN in mg/dL
Glucose in mg/dL
Free water deficit
Free water deficit (L) = (current [Na]/ normal [Na] - 1) * 0.6 * body weight
Sodium deficit
Sodium deficit = (target [Na] - patient [Na]) * 0.6 * body weight
Henderson-Hasselbalch equation
pH = 6.1 + log [HCO3] / (0,03 * pCO2)
6.1 is the pKa in body fluids
0.03 is the solubility coefficient for carbon dioxide in
plasma
Anion gap
Anion gap = [Na] + [K] - ([HCO3] + [Cl])
Strong ion difference
Strong ion difference = (sodium + potassium) - (chloride)
Total weak acid concentration (Atot)
Atot = albumin effect + phosphorus effect
Strong ion gap
[SID - (bicarbonate + Atot)]
Simplified SIG dogs
SIG simplified = [albumin] * 4.9 – AG
Simplified SIG cats
SIG simplified = [albumin] * 7.4 - AG
Free water effect dogs
0.25([Na] - mid-normal [Na])
Free water effect cats
0.22([Na] - mid-normal [Na])
Corrected chloride
measured [Cl] * (mid-normal [Na]/
measured [Na])
Chloride effect
mid-normal [Cl] - corrected [Cl]
Lactate effect
-1 * [lactate]
Sum of effects in semiquantitative approach
free water effect + chloride effect + phosphorus effect + albumin effect + lactate
effect
Unmeasured ion effect
base excess - sum of effects
Fractional excretion of sodium (FeNa)
FeNa = 100 * (Urine [Na] * Plasma [Creatinine] / Plasma [Na] * Urine [Creatinine])
Transtubular potassium gradient
(Urine [K] * Plasma osmolality) / (Urine osmolality
* Plasma [K])
Urinary free water clearance
urine volume * (1 - (Urine [Na] + Urine [K]) / Serum [Na])
CVC collapsibility
CVC CI = CVCd max – CVCd min / CVCd max
RER
70*(BW^0,75 ) /24 h
Dehydratation deficit
body wt (kg) * % dehydration (as decimal) * 1000 (ml/L)
Effective osmolality
2*[Na] + [glucose (mg/dl) / 18]
Corrected sodium
Na(meas) + 1.6 ([measured glucose – 100] / 100)
amended insulin/glucose ratio
(AIGR)
(insulin 100) / (plasma glucose - 30)
Monroe-Kelly doctrine
Vintracranial = V brain + V CSF + V blood + V mass/lesion
Dog plasma volume
(1 – hematocrit) * (body weight [kg] * 85 ml/kg)
HCT in decimals
Cat plasma volume
(1 – hematocrit) * (body weight [kg] * 55 ml/kg)
HCT in decimals
Mean arterial blood pressure
1) Diastolic P + (systolic - diastolic) / 3
2) Diastolic P + 1/3 Pulse pressure
Pulse pressure variation (PPV)
PPV (%) = 100 * (PPmax - PPmin) / [(PPmax + PPmin) / 2]
Systemic vascular resistance
1) SVR = (MAP - CVP) / CO
2) SVR (mmHg/ml/kg/min) = (MAP - CVP) / CI (ml/kg/min)
3) SVR (dynes * sec/cm^5 ) = ([MAP - CVP] * 79.9) / CI (L/min/m^2)
Cardiac output (Fick method)
CO = VO2 / (CaO2 - CvO2)
Functional SO2
[(HbO2)/(HbO2 + HHb)] * 100
Fractional SO2
[(HbO2)/(HbO2 + HHb + COHb+1 MetHb)] * 100
Colloid osmotic pressure
COP = 2.1P + 0.16P^2 + 0.009P ^3
P = Plasma protein
Abdominal perfusion pressure
mean arterial pressure (MAP) - intraabdominal pressure (IAP)
Filtration gradient
glomerular filtration pressure - proximal tubule pressure = MAP - 2*IAP
Urine volume on POCUS
Vurine (ml) = (L * W * (dl + DT)/2) * 0.52
L = length of the bladder (longitudinal)
W = width of the bladder (transverse)
dl = depth of the bladder (longitudinal)
DT = depth of the bladder (transverse)
cardiac index (CI) (2)
1) CI (ml/kg/min) = CO (ml/min) / BW (kg)
2) CI (L/m^2/min) = CO (L/min) / body surface area (m^2)
Oxygen consumption index (from Fick equation)
VO2 (ml/kg/min) = CI (ml/kg/min) * (CaO2- CmvO2 ) / 100
Oxygen extraction ratio
OER (%) = (CaO2 - CmvO2) / CaO2
Pulmonary vascular resistance (2)
1) PVR (mmHg/ml/kg/min) = (PAP - PAOP) / CI (ml/kg/min)
2) PVR (dynes*sec/cm^5) = ([PAP - PAOP] * 79.9) / CI (L/min/m^2)
PAP = pulmonary artery pressure
PAOP = pulmonary artery occlusion pressure
Stroke volume (SV) (2)
1) SV (ml/beat/kg) = CI (ml/kg/min) / HR
2) SV (ml/beat/m^2) = CI (ml/min/m^2) / HR
Fractional shortening
FS = [LVIDd - LVIDs] / LVIDd * 100
Ejection fraction
EF = (LVVd - LVVs) / LVVd * 100
Static compliance
C stat = VT / (Pplat - PEEP)
Dynamic compliance
C dyn = VT / (PIP - PEEP)
Inspired resistance
RI = (PIP - Pplat) / VT
Transpulmonary pressure
TPP = Palv - Ppl
Driving pressure
deltaP = Pplat - PEEP
Osmole gap
measured osmolality - calculated osmolality
Total body water
0 6 * BW (kg)
Laplace law
P = 2t / r
t = wall thickness
r = radius
Modified Bernoulli equation
deltaP = 4*V^2
Poiseuille’s law
Resistance = (8 n * l) / (2pi*r^4)
n = viscosity
l = lenght
r = radius
Reynolds number
Re = (D* rho* V) / n
D = diameter
rho = density
V = velocity
n = viscosity
Wall stress
sigma = liniary correlated to (P * R) / 2t
sigma = wall stress
P = pressure
R = resistance
t = thickness
Compliance
Delta V / Delta P
Elastance
Delta P / Delta V
Total dead space
anatomical + apparatus + alveolar dead spaces
Alveolar-arterial PO2 gradient
PAO2 = (Patm – PH2O) x FiO2 – (PaCO2/0.8)
Velocity in blood vessel
Blood flow (F) / Area of blood vessel (A)