Definitions

Question 1

Sepsis

Answer 1

Life-threatening organ dysfunction caused by a dysregulated host reponse to infection

Question 2

CIRCI

Answer 2

CIRCI is a dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, leading to an inadequate cortisol response to stress in critically ill patients.

Associated with refractory hypotension, poor response to vasopressors, and systemic inflammation.