formative Flashcards

1
Q

what is aortic incompetence?

A

aortic regurgitation
leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. As a consequence, the cardiac muscle is forced to work harder than normal.

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2
Q

what is pericardial tamponade?

A

Cardiac tamponade, also known as pericardial tamponade, is when fluid in the pericardium (the sac around the heart) builds up, resulting in compression of the heart. Onset may be rapid or gradual.

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3
Q

what is right ventricular hypertrophy?

A

Right ventricular hypertrophy (RVH) is a condition defined by an abnormal enlargement of the cardiac muscle surrounding the right ventricle. … Therefore, the main causes of RVH are pathologies of systems related to the right ventricle such as the pulmonary artery, the tricuspid valve or the airways.

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4
Q

what is a pansystolic murmur?

A

start at S1 and extend up to S2. They are usually due to regurgitation in cases such as mitral regurgitation, tricuspid regurgitation, or ventricular septal defect

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5
Q

what is cyanosis?

A

Cyanosis refers to a bluish cast to the skin and mucous membranes. Peripheral cyanosis is when there is a bluish discoloration to your hands or feet. It’s usually caused by low oxygen levels in the red blood cells or problems getting oxygenated blood to your body

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6
Q

what are the causes of clubbing?

A
Cyanotic heart disease/CF 
Lung cancer/abscess
Ulcerative colitis
Bronchiectasis
Benign mesothelioma
Infective endocarditis/idiopathic pulmonary fibrosis
Neurogenic tumours
Gastrointestinal disease
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7
Q
  1. what does absence of JVP ‘a’ wave suggest?

2. what does a large jugular ‘V’ wave suggest?

A
  1. The absence of ‘a’ waves may be seen in atrial fibrillation.
  2. An elevated JVP is the classic sign of venous hypertension (e.g. right-sided heart failure).
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8
Q

what causes a left parasternal heave?

A

Parasternal heave occurs during right ventricular hypertrophy (i.e. enlargement) or very rarely severe left atrial enlargement.

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9
Q

what is pulse paradoxus?

A

abnormally large decrease in stroke volume, systolic blood pressure and pulse wave amplitude during inspiration

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10
Q

what is a collapsing pulse?

A

pulse that is bounding and forceful, rapidly increasing and subsequently collapsing, as if it were the sound of a waterhammer that was causing the pulse.

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11
Q

what is the likely diagnosis for the following clinical scenario?
A 54-year-old man with a medical history of hypertension, diabetes, dyslipidaemia, smoking, and family history of premature coronary artery disease presents with retrosternal crushing chest pain (10/10 in intensity), radiating down the left arm and left side of the neck. He feels nauseated and light-headed and is short of breath. Examination reveals hypotension, diaphoresis, and considerable discomfort with diffuse bilateral rales on chest auscultation. ECG reveals convex ST-segment elevation in leads V1 to V6.

A

STEMI

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12
Q

what is the likely diagnosis for the following clinical scenario?
A 45-year-old woman presents with constant chest pain that is worsened by movement and deep inspiration. The pain started gradually several weeks ago and has been worsening over the past few days. She denies any shortness of breath on exertion and feels otherwise well. She has tenderness over the right third and fourth costochondral junctions. The rest of her examination is unremarkable

A

chest wall pain/costochondritis

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13
Q

what is the likely diagnosis for the following clinical scenario?
A 60 year old female smoker with a history of CAD presents with chest discomfort on exertion relieved by nitroglycerine or rest. There is no change in intensity, frequency, or duration; no associated diaphoresis, nausea/vomiting, or shortness of breath.

A

chronic stable angina / angina pectoris

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14
Q

what is the likely diagnosis for the following clinical scenario?
A 65-year-old man presents with a 2-month history of a dry persistent cough and 4.5 kg unintentional weight loss. He denies fevers, dyspnoea, sore throat, rhinorrhoea, chest pain, or haemoptysis. Past medical history is significant for chronic obstructive pulmonary disease and hypertension. Family history is non-contributory. He smoked 1 pack of cigarettes daily for 40 years but quit 5 years ago. No adenopathy was palpable on examination and breath sounds were diminished globally without focal wheezes or rales

A

lung cancer

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15
Q

what is the likely diagnosis for the following clinical scenario?
A 23-year-old man with asthma and seasonal allergies presents to the accident and emergency department with an acute food bolus impaction. He has had solid food dysphagia since primary school, but had always been told to chew more carefully. He has not had any prior evaluation, and has never been to the emergency department before, but does have a sensation of food sticking with almost every meal. He minimises symptoms by eating slowly, chewing thoroughly, and drinking a lot of water with each bite of food. He tends to avoid dry breads and steak, as these always stick. Most of the time when foods stick, if he relaxes himself they will eventually go down. However, sometimes he has to clear the foods with regurgitation. The endoscopic examination shows a food bolus impacted in the proximal oesophagus, which is cleared. The oesophagus is diffusely narrowed, with oedema, rings, and furrows. Biopsies show 85 eosinophils per high-power microscopy field (eos/hpf) from the distal oesophagus and 70 eos/hpf from the proximal oesophagus. He is started on the proton-pump inhibitor (PPI) omeprazole (20 mg orally twice daily) and has a follow-up endoscopy scheduled in 8 weeks’ time. He continues to have frequent dysphagia. The endoscopic findings and biopsy results are unchanged and he is diagnosed with eosinophilic oesophagitis (EoO).

A

eosinophilic oesophagitis

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16
Q

what is the likely diagnosis for the following clinical scenario?
An otherwise healthy 30-year-old man presents with a several-day history of progressive, severe, retrosternal chest pain that is sharp and pleuritic in nature. The pain is worse on lying down and improved with sitting forward. There is radiation to the neck and shoulders and specifically to the trapezius muscle ridges. The pain is constant and unrelated to exertion. On physical examination, a pericardial friction rub is heard at end-expiration with the patient leaning forward.

A

pericarditis

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17
Q

what is the likely diagnosis for the following clinical scenario?
A 70-year-old woman presents with slowly increasing dyspnoea. She cannot lie flat without feeling more short of breath. She has a history of hypertension and osteoarthritis, and she has been taking non-steroidal anti-inflammatory drugs with increasing frequency over the previous few months. On physical examination, she appears dyspnoeic at rest, her blood pressure is 140/90 mmHg, and pulse is 90 bpm. Her jugular venous pressure is elevated to the angle of the jaw. The left lung field is dull to percussion with quiet breath sounds basally. Crackles are heard in the right lung field and above the line of dullness on the left. Lower extremities have pitting oedema to the knee

A

pleural effusion

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18
Q

what is the likely diagnosis for the following clinical scenario?

A 54-year-old smoker with multiple comorbidities (diabetes, hypertension, coronary artery disease) presents with a 2-day history of a productive cough with yellow sputum, chest tightness, and fever. Physical examination reveals a temperature of 38.3°C (101°F), BP of 150/95 mmHg, heart rate of 85 bpm, and a respiratory rate of 20 breaths per minute. His oxygen saturation is 95% at rest; lung sounds are distant but clear, with crackles at the left base. Chest x-ray reveals a left lower lobe infiltrate.

A

pneumonia

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19
Q

what is the likely diagnosis for the following clinical scenario?

A 65-year-old man presents to the emergency department with acute onset of shortness of breath of 30 minutes’ duration. Initially, he felt faint but did not lose consciousness. He is complaining of left-sided chest pain that worsens on deep inspiration. He has no history of cardiopulmonary disease. A week ago he underwent a total left hip replacement and, following discharge, was on bed rest for 3 days due to poorly controlled pain. He subsequently noticed swelling in his left calf, which is tender on examination. His current vital signs reveal a fever of 38.0°C (100.4°F), heart rate 112 bpm, BP 95/65 mmHg, and an O₂ saturation on room air of 91%.

A

pulmonary embolism

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20
Q

what is the likely diagnosis for the following clinical scenario?

A 65-year-old man, who smokes and has a history of hypertension and peripheral vascular disease, now presents with increasing frequency and severity of chest discomfort over the past week. He reports that he previously had chest pain after walking 100 metres, but now is unable to walk more than 50 m without developing symptoms. The pain radiates to the left side of the neck and is only eased after increasing periods of rest

A

unstable angina

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21
Q

what is nocturnal burning chest pain suggestive of?

A

GORD

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22
Q

what is guillan barre syndrome?

A

rare but serious autoimmune disorder in which the immune system attacks healthy nerve cells in your peripheral nervous system (PNS). This leads to weakness, numbness, and tingling, and can eventually cause paralysis.

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23
Q

what is pickwickian syndrome?

A

Obesity hypoventilation syndrome (OHS), also known as Pickwickian syndrome, is a condition in which severely overweight people fail to breathe rapidly or deeply enough, resulting in low oxygen levels and high blood carbon dioxide (CO2) levels

24
Q

what is the potential diagnosis for the following ABG results?

  1. normal PaCO2, PaO2 > 60 mmHg
  2. PaCO2 > 45 mmHg, PaO2 < 60 mmHg
A

COPD

  1. pink puffer
  2. blue bloater
25
Q

what is the potential diagnosis for the following ABG results?

low bicarbonate, and low pH (less than 7.3)

A

diabetic ketoacidosis

26
Q

what is the potential diagnosis for the following ABG results?
↑ pH
↓ CO2

A

hyperventilation - respiratory alkalosis

27
Q

what is a CEA test?

A

A carcinoembryonic antigen (CEA) test is a blood test used to help diagnose and manage certain types of cancers. The CEA test is used especially for cancers of the large intestine and rectum.

28
Q

what is the likely diagnosis from the following clinical presentation?
A 72-year-old man presents to his primary care physician with a history of increasing shortness of breath over a period of several months. Before his retirement he was a construction worker. Physical examination reveals decreased breath sounds in the right lung base associated with dullness to percussion.

A

mesothelioma

29
Q

what occupational hazard produces an acute bronchial reaction?

A

chlorine

30
Q

what occupational hazard can cause fibrosis?

A

coal

31
Q

what occupational hazards can cause asthma?

A

paint spray (2 pack isocyanates, bakers, food processors, nurses, chemical workers, animal workers, welders, hairdressers, timber workers)

32
Q

what is the occupational hazard from PVC?

A

hepatotoxic

33
Q

what sign on auscultation would be seen in a patient with left ventricular failure

A

3rd heart sound

34
Q

treatable causes of high blood pressure

A

disease causing high aldosterone levels which can cause hypertension and excessive urinary potassium losses (renal artery stenosis and tumours of adrenal gland such as conns syndrome=primary hyperaldosteronism / bushings syndrome can lead to hypokalaemia because of excess cortisol binding with sodium potassium pump and acting like aldosterone / hypertension and hypokalaemia can be seen with 11 beta hydroxysteroid dehydrogenase type 2 enzyme deficiency known as apparent mineralocorticoid excess syndrome

35
Q

what are the causes of apparent mineralocorticoid excess syndrome?

A

congenital

consumption of glycyrrhizin (in liquorice, herbal supplements, candies and chewing tobacco)

36
Q

what do eosinophils produce in response to an allergen?

A

leukotrienes

37
Q

what do B cells produce?

A

IgE and IgM

38
Q

what do mast cells produce?

A

histamine

39
Q

what is the main characteristic of an acute asthma attack?

A

bronchial mucus plugging

40
Q

what is the likely diagnosis from the information below
unilateral pleural effusion
protein 40g/L
lactate dehydrogenase 1000IU/L

A

lung cancer

high protein and LDH shows exudate usually secondary to malignancy or infection

41
Q

what does a low PFR value suggest?

A

airways disease

42
Q

describe the following investigation findings in a patient with PE

  • neutrophil leukocytosis
  • ABG
  • CXR
A

neutrophil leukocytosis is non specific finding
low pco2 due to hyperventilation
normal CXR good way to differentiate PE from other causes of breathlessness

43
Q

describe the features of pleuritic chest pain

A

worse on inspiration
inflammatory, infective or infiltrative
rub may be heard over site of pain

44
Q

what drugs interact with warfarin clinically?

A

alcohol
co-trimoxazole
oestrogen progestin contraceptive pill
phenobarbitone

45
Q

what is idiopathic pulmonary arterial hypertension?

A

secondary to persistently increased foetal pulmonary HTN
gradual, irreversible progression
exertion dyspnoea
X-rays show clear lungs and big central Pas with pruned vessels
female to male 2-9:1

46
Q

describe the features of pulmonary hypertension

A

commonest forms are those occurring secondary to chronic lung disease and left ventricular failure
pulmonary hypertension and right ventricular hypertrophy (cor pulmonate) may complicate COPD
any cause of left ventricular failure can lead to pulmonary venous congestion and hence pulmonary hypertension
unidentified mitral stenosis may present with symptoms of RVHF

47
Q

signs of infective endocarditis?

A
FROM JANE
fever
roth's spots
oslers nodes
murmur
janeway lesions
anaemia
nail haemorrhage (splinter haemorrhage)
emboli
48
Q

causes of transudative pleural effusions?

A
congestive heart failure
hepatic cirrhosis 
hypoproteinemia 
nephrotic syndrome 
acute atelectasis 
myxoedema 
peritoneal dialysis 
meig's syndrome
obstructive uropathy
49
Q

causes of exudative pleural effusions?

A
malignancy infection
trauma
pulmonary infarction 
PE
autoimmune disorders
pancreatitis
ruptured oesophagus (boerhaaves syndrome)
rheumatoid pleurisy 
drug induced lupus
TB
50
Q

A 65-year-old man presents with gradually progressive dyspnoea on exertion and a non-productive cough. He has no history of underlying lung disease and no features that would suggest an alternative aetiology for his cough and dyspnoea. He has no history of joint inflammation, skin rashes, or other features of a systemic inflammatory disease such as lupus or rheumatoid arthritis. He takes no medications and has no environmental exposures to organic allergens such as mould. On examination, he has fine crackles audible over his lung bases bilaterally; however, he has no lower-extremity oedema, elevations in jugular venous pressure, or any other findings to suggest volume overload. He has clubbing of his fingers.

A

idiopathic pulmonary fibrosis

51
Q

according to BTS hypertension guidelines when should extra drugs be added to a medication regimen?

A

maximise and optimising doses of existing drugs before adding any others

52
Q

what investigation would be undertaken to give information about the effect of aortic stenosis?

A

stress echocardiography with exercise tolerance testing

53
Q

in rate limiting treatment of AF what drug should be given to produce the quickest affect and compare this to other rate limiting drugs?

A

metoprolol as it has a short half life with rapid onset

amiodarone long duration and slow onset
bisoprolol-OD, long half life, slower onset
digoxin half life 35 hours and 5-7 days to reach steady state

54
Q

what class of drug can cause peripheral oedema due to the redistribution of fluid from vascular space into interstitium?

A

calcium channel blockers

55
Q

describe drug interactions that can potentially cause hyperkalaemia?

A

patients receiving any regimen involving one or more RAAS inhibitors such as ACE inhibitors, ARBs and aldosterone antagonists