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Ocular Phys Block 10 > Formation And Function Of Aqueous Humor > Flashcards

Formation And Function Of Aqueous Humor Flashcards

1
Q

Clear colorless fluid that fills the anterior and posterior chamber of the eye

A

Aqueous humor (AH)

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2
Q

Functions of aqueous humor

A
  • nutrients and O2 to remove metabolic wastes from the anterior intraocular tissues
  • inflates the eye globe and creates IOP for normal and optical functioning of the eye
  • transports asocrbic acid into anterior where is serves as an antioxidant agent
  • facilitates the local immune responses during inflammation and infection
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3
Q

Primary site of AH formation

A

Par plicata

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4
Q

What layer of epithelium forms AH

A

NPCE

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5
Q

Average rate of formation of aqueous humor

A

2.75ul/min (daytime) and 1.08ul/min (night)

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6
Q

When is aqueous production increased

A

Daytime

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7
Q

What makes you 99% of AH

A

Water

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8
Q

Where is ascorbic acid higher, blood or AH

A

AH

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9
Q

Where is protein higher, blood or AH

A

Blood

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10
Q

Purpose of ascorbic acid in AH

A

Against photo-oxidative damage

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11
Q

Purpose of low protein in AH

A

Free of protein to maintain optical transparency

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12
Q

Where do all the proteins in the AH come from

A

Blood plasma, not synthesized

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13
Q

How does blood synthesize Ah

A
  1. Blood flow to ciliary stroma
  2. Loading solutes from blood plasma to pigmented epithelium
  3. Solutes translocates to NPCE through gap junctions
  4. Solutes excluded from NPCE into posterior chamber
  5. Osmotic gradient create, causing passive water flow to posterior chamber
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14
Q

Mechanisms of solutes across the CE

A
  1. Diffusion
  2. Ultrafiltration
  3. Active transport
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15
Q

What is the major player in moveing solutes across the CE

A

Active transport

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16
Q

Energy dependent process moves substance against its electrochemical gradient

A

Active transport

17
Q

Why is carbonic anhydrase important

A

To generate the hydrocarbonate ion. Regulates the aqueous porduction. If we suppress this, we can reduce the aqueous humor formation

18
Q

What is a good drug to give someone to reduce AH formation for glaucoma

A

Carbonic anhydrase inhibitor

B2 blocker

19
Q

Supports active transport of Na ions across cilioary epithelium and increase aqueous humor formation

A

Vasopressin

20
Q

Inhibits adenylcyclase, decreases aqueous humor formation

A

Alpha 2 adrengeric agoinist

21
Q

Stimulates adenylcyclase- increase aqueous humor formation

A

Beta 2 adrenergic agonist

22
Q

Factors rescue AH information

A
  • diurnal cycle
  • uveitis
  • retinal detachment
  • drugs
  • tetrahydrocannabinol (marijuana)
23
Q

Which layer of the CE is necessary for AH formation

A

Nonpigemnted epithelium

Ocular Phys Block 10 (5 decks)

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