Forelæsning 3 Flashcards

1
Q

neoplastiske celler

A

tumor celler

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2
Q

Stroma

A

Det understøttende skelet af et organ

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3
Q

Lymphoma

A

tumor, som består af hvide blodlegemer

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4
Q

Reed-stenberg celler

A

Multinucleated celler; med mange cellekerner

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5
Q

uPAR? hvorfor

A

serin protease urokinase-type plasminogen aktivator receptor. Hjælper cancerceller med at synke dybere i vævet og bevæge sig mere frit.

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6
Q

CAFs? funktionen?

A

Cancer associated fibroblasts. De hjælper cancercellerne med at proliferere på højere niveau.

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7
Q

Tumor associerede makrofager

A

De hjælper cancercellerne med at proliferere på højere niveau

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8
Q

Hvad rammer DNA-onkovira? og hvorfor?

A

Tumor supressor gener såsom p53 og retinoblastoma, fordi disse gener vil inaktivere celledeling, når viraene prøver at replicere deres DNA

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9
Q

Episomalt DNA

A

ikke integreret DNA

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10
Q

RNA-onkovira?

A

retrovira som f.eks. rous sarcoma virus

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11
Q

v.src

A

protein tyrosin kinase forårsager nogle forkerte cellevækst signaler

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12
Q

Hvordan kan vira resultere i celletransformationer?

A

1- At de selv har onkogener med
2- inertional mutagenese; deres genom kan insertes et sted hvor nogle proto-onkogener ligger. og hvis viral promotor er meget aktiv, så vil den forårsage enn overekspression af proteinet

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13
Q

Driver gener

A

Er gener, der koder for proteiner, der kontrollerer cellecyklusser

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14
Q

Telomerase

A

Høj aktivitet i cancerceller for at sørge for telomerene bliver ikke kortere og kan dermed undgå død

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15
Q

Hvad indeholder en reverse transkriptase?

A

To subunits.
hTERT: telomerase reverse transskriptase
hTR: RNA-template

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