E-timer Flashcards

1
Q

MPK (G2/M)

A

CDK1 +cyklin B

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2
Q

Hvilken komponent fosforylerer Y15 og Y14?

A

wee1 eller myt1

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3
Q

Hvilken komponent defosforylerer Y15 og T14?

A

Cdc25

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4
Q

Hvilken komponent fosforylerer T161?

A

CAK

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5
Q

Cdc25 deletion

A

Arrest

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6
Q

CAK inhibering

A

Ingen adgang til mitosen

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7
Q

wee1 inaktiverende mutation

A

En hurtigere adgang til mitosen

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8
Q

Overaktive wee1

A

Arrest

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9
Q

Hvad gør ATM og ATR kinaser og hvornår bruges de?

A

De fosforylerer og aktiverer CHK1 og CHK2, når DNA’et er skadet. CHK1 og CHK2 medfører degraderingen eller inhbitionen af CDC25 og CHK1 aktiverer Wee1 (som fosforylerer Y15 og T14 resterne)

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