Forebrain 1 Flashcards

1
Q

How many layers are there in the neocortex?

A

6 layers

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2
Q

What is the functional unit of the cerebral cortex in most areas?

A
  • A column of cells
  • These extend through all the cortical layers
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3
Q

From which layer of the neocortex does the corticospinal axons arise from?

A
  • Layer V (5)

These are quite large neurones (they have to go a long way)

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4
Q

Where is the functional organisation of columns best seen in the neocortex?

A
  • Sensory Areas (E.g. primary visual cortex)
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5
Q

What does the neocortex include?

A

Most of the cortex except for:

  1. Olfactory Area
  2. Limbic Area
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6
Q

What are axons that leave the cerebral cortex called?

A
  • Pyramidal Output Neurones
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7
Q

What happens to the number of interneurones & pyramidal nerves as we get smarter?

A
  • Percentage of Pyramidal Neurones –> DECREASES
  • Number of Stellate Interneurones –> INCREASES
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8
Q

What are the 2 important cell types in the cerebral cortex?

A
  • Pyramidal Output Neurones
  • Stellate Interneurones
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9
Q

What are the 4 main lobes of the cerebral hemisphere?

A
  1. Frontal
  2. Parietal
  3. Temporal
  4. Occipital
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10
Q

Why is the cerebral cortex arranged in columns (folds/gyri)?

A
  • Increase Computing Power
  • Folds allow you to increase the number of columns you can put
  • Allows you to increase the area so you can increase the folds

NB: Most of the cerebral cortex (and brain) is surplus to requirements for basic survival (e.g. speech area)

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11
Q

What is the division between the frontal & parietal lobe?

A
  • Central Sulcus

Infront –> FRONTAL LOBE

Behind –> PARIETAL LOBE

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12
Q

Describe tha path of the central sulcus?

A
  • Runs from the midline
  • All the way down to lateral side of the hemisphere
  • It does not meet the lateral fissure (cut off by gyrus)

NB: The only sulcus which has a gyrus in front & behind it

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13
Q

How do you demarcate the occipital lobe?

A
  • Poorly demarcated
  • Best way is to go from notch to parietal-occipital sulcus (midline)
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14
Q

What is an extension of the central sulcus?

A
  • Central Sulcus of Rolando
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15
Q

What is another name for the lateral fissure?

A
  • Sylvian Fissure
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16
Q

What is the original structure that the cerebral hemispheres grow out of?

A
  • Diencephalon

NB: Original diencephalon (not outgrowth) becomes the midbrain

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17
Q

Where is the 3rd ventricle found?

A
  • Midline
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18
Q

How many horns does the lateral ventricle have and what are they called?

A
  • Frontal Horn (into frontal lobe)
  • Occipital Horn (into occipital lobe)
  • Temporal Horn (into temporal lobe)
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19
Q

Where do the lateral ventricles open up to?

What is the hole that connects them called?

A
  • Open up to 3rd ventricle
  • Open up from both sides (into one 3rd ventricle)
  • connect via the intraventricular foramen
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20
Q

Locate the following on this diagram:

  • Lateral Fissure
  • Lateral Ventricle
  • 3rd Ventricle
  • Temporal Lobe
  • Gyrus
  • Sulcus

What plane is this taken in?

A
  • Coronal Section/Plane
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21
Q

Locate the Parieto-occipital sulcus on this diagram.

Can this be seen on the medial or lateral side?

What lobes are infront and behind the sulcus?

A
  • Seen on the medial side
  • Arbitrary on the lateral side

Infront of Sulcus –> Parietal Lobe

Behind Sulcus –> Occipital Lobe

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22
Q

What is the occipital lobe associated with?

A
  • Vision
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23
Q

Locate the corpus callosum.

What is its main function?

A
  • Great Commisure
  • Main connection between both hemispheres

Axons cross the midline connecting both hemispheres

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24
Q

Where is the insular cortex found?

A
  • Deep Cortex found Deep in the Lateral Fissure
  • Embedded in the Floor of the Insular Cortex

Cannot see the insular cortex from the outside

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25
Q

what is the function of the insular cortex?

A
  • Second Somatosensory Cortex Centre
  • Important in Pain Sensation
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26
Q

What goes across (crosses over) the insular cortex that is very important?

Which fissure does this occur in?

A
  • Middle Cerebral Artery (MCA)

It crosses over the insular cortex in the lateral fissure

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27
Q

Name the gyri which are pointed to here.

A
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28
Q

What happens to the gyri and sulci as you get older?

A
  • Sulci –> WIDER
  • Gyri –> THINNER
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29
Q

What is the gyrus in front of the central sulcus called?

A
  • Pre-Central Gyrus
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30
Q

What are the 3 gyri on the lateral surface of the frontal lobe called?

A
  1. Superior Frontal Gyrus
  2. Middle Frontal Gyrus
  3. Inferior Frontal Gyrus
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31
Q

Describe the superior frontal gyrus?

A
  • Wiggles up from the upper margin of the lateral surface of the frontal lobe
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32
Q

Describe the middle frontal gyrus?

A
  • Wiggles along the side of the frontal lobe
  • Continuous with the lower part of the pre-central gyrus (not shown in pic)
  • Very convoluted
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33
Q

Describe the inferior frontal gyrus?

A
  • Wiggles on the Top of the Lateral Fissure
  • Highly convoluted
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34
Q

What are the 3 gyri of the lateral temporal lobe called?

A
  1. Superior Temporal Gyrus (easily seen)
  2. Middle Temporal Gyrus (easily seen)
  3. Inferior Temporal Gyrus (not easily seen)

NB: Sometimes ITG found on the underside

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35
Q

Where are the superior & inferior temporal sulci found?

A
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36
Q

Where is the post-central gyrus found?

A
  • Behind the Central Sulcus
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37
Q

Where is the supramarginal gyrus found?

A
  • Cuts off the end of the lateral fissure
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38
Q

Where is the angular gyrus found?

A
  • Cuts off the end of the Superior Temporal Sulcus
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39
Q

Which gyrus cuts off the end of the lateral fissure?

A
  • Supramarginal Gyrus
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40
Q

Where is the intraparietal sulcus found?

A
  • Black line in image
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41
Q

What is the superior temporal sulcus walled off by?

A
  • Cut off by the angular gyrus
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42
Q

Which lobe is the angular & supramarginal gyrus part of?

A
  • Parietal Lobe
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43
Q

What is the paracentral lobule important for?

A
  • Motor & Sensory Fibres of the Lower Limb
  • Found either side of the central sulcus
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44
Q

What does the cingulate gyrus go around?

A
  • Corpus Callosum
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45
Q

What is the uncus?

A
  • Bump at the end
  • Found on the medial side of the temporal lobe
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46
Q

What lobe is the parahippocampal gyrus part of

A
  • Temporal Lobe
  • Deepest part of temporal lobe
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47
Q

What is the calcarine sulcus important for?

A
  • Important for demarcating the visual area

NB: Lots of visual information at occipital pole

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48
Q

Other structures of the brain.

A
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49
Q

Where is the fusiform gyrus?

What is it important for?

A
  • Lateral to the Parahippocampal Gyrus
  • Part of Temporal Lobe
  • Found on the inferior surface of the temporal lobe
  • Important for recognising things
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50
Q

What is brodmann’s area of the cerebral cortex based on?

A
  • Based on Histology
  • Histology reflects function
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51
Q

What two characteristics were used to divide brodmann areas up?

NB: Although the second one just happened to link to the first one

A
  1. Histology
  2. (reflects) Function

Cerebral Cortex divided into different (brodmann) areas –> due to different histology –> which happened to have different functions

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52
Q

Give 3 ways how functional localization in the cerebral cortex can be figured out.

A
  1. Pathology
  2. Stimulation (electrical)
  3. fMRI (functional MRI)
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53
Q

Where is broca’s area found?

A
  • Left Hemisphere
  • Dominant Side (usually left hemisphere only)
  • V-Shape

Found just above the anterior part of the lateral fissure

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54
Q

What is found in broca’s area?

What is it needed for?

A
  • Usually contains Language Centre
  • Important in Fluent Speech
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55
Q

What is a sign of damage in Broca’s Area?

A
  • If someone cannot give fluent speech
  • Cannot speak
  • They can however understand speech
  • Regarded as a motor speech problem

Broca’s area is neccessary for fluent speech function

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56
Q

Why can electrical stimulation of the brain be done on conscious patients?

A
  • There are no nociceptive receptors in the brain
  • Only needs to be accessed using local anaesthetics
  • Patients will not feel you poking/sucking things out from their head

NB: Some neurological surgeries are done under local anaesthetics to figure something out (e.g. keep talking to patient whilst working on broca’s area so that it is not affected)

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57
Q

What area is primarily responsible for movements with the lowest stimulation?

What tract are they associated with?

Do they control the ipsilateral or contralateral side?

A
  • Primary Motor Cortex (M1)
  • Brodmann Area 6

Can produce movement here with the lowest stimulation

  • Will activate the corticospinal system (lots of cell bodies are in M1)
  • It is active during any voluntary movement
  • Controls movement on the contralateral side of the body

NB: Causes twitching when stimulated

58
Q

Which area of the brain is active during ancitipation of movement (thinking about it)?

Which side of the brain is active?

A
  • Supplementary Motor Area

Active even when not moving

Could just be thinking about making a movement. Even if the movement is for one side of the body only it will activate both sides

59
Q

What is the general somatotopic organisation of the motor cortex?

What is a ‘somatotopic organisation’?

A
  • Lateral Side (below) –> LARYNX
  • Medial Side (top) –> HAND
60
Q

Where is the frontal eye field found?

A
  • Posterior to the Middle Frontal Gyrus
  • Anterior to the Premotor Area
  • Found in both hemispheres
61
Q

When is the frontal eye field active?

A
  • Allows conjugate movement of the eye (eyes to move together)
62
Q

What happens if one side of the frontal eye field is stimulated?

A
  • Both eyes will look to the other side
63
Q

What happens if there is a lesion of one of the frontal eye fields?

A
  • Both eyes will deviate to the side with the lesion
64
Q

What defines which hemisphere is the dominant hemisphere?

A
  • Broca’s Area defines the Dominant Hemisphere
  • Usually this is on the left

NB: Broca’s area is to do with speech

65
Q

What happens if there is a speech problem to do with broca’s area in childhood?

A
  • Can be sorted
  • Otherside can take over & take control
66
Q

Which gyrus is the somatosensory cortex (S1)?

Which lobe is this found in?

Which part of the brain does information relay before going to S1?

A
  • Post-central gyrus
  • Parietal Lobe
  • Incoming information goes to thalamus which is relayed to S1
67
Q

What is the frontal lobe predominantely involved in?

A
  • Motor Functions
68
Q

What happens if you give premotor area electrical stimulation?

A
  • Requires higher levels of intense stimulation
  • Produces complicated movements
  • Movements on the contralateral side
69
Q

Where is the pre-motor area?

A
  • Found in front of the primary motor area (M1)
  • It is a triangular area (area 4)
  • It is not clearly demarcated
70
Q

What brodmann areas are premotor & primary motor cortex?

A
  • Premotor Cortex –> Area 4
  • Primary Motor Cortex –> Area 6
71
Q

Where is the supplementary motor area?

A
  • Medial Surface of Cerebral Hemisphere
  • Corticospinal Neurones arise from here
  • Very complicated
  • Involved in planning of movements
72
Q

Summarise how you would activate:

  • Primary Motor Cortex
  • Supplmentary Motor Cortex
A
  • Produce Movement –> causes PRIMARY MOTOR CORTEX (M1) to be active on the CONTRALATERAL SIDE
  • Sit & think about a movement –> causes the SUPPLEMENTARY HEMISPHERES to be ACTIVE BILATERALLY
73
Q

What varies in terms of the layers as you go throughout the cortex?

A
  • Thickness (depending on which part of cerebral cortex)
74
Q

What is the general pattern of the somatotopic map?

A
  • Face –> LATERAL
  • Foot –> MEDIAL

NB: Paracentral region on either side is for lower limbs

75
Q

What are the paracentral regions on either side in charge of?

A
  • Lower Limbs
76
Q

What is the organisation of the motor complex like?

A
  • Complex
  • There is not one corticospinal axon per muscle
  • Corticospinal axons have widespread terminals
77
Q

Where are corticospinal cell bodies found?

A
  • Motor Cortices
  • Other Areas (not all motor function)
78
Q

Where do these corticospinal axons go?

  • Head & Neck
  • Rest of Body
A
  • Head & Neck –> Dorsal Column Nuclei
  • Rest of Body –> Dorsal Horn of Spinal Cord

NB: Note that this is one long axon which goes all the way to these places (no synapses)

79
Q

What are the functions of the corticospinal axons?

A
  • Motor Control (movement)
  • Modulation of Sensory Functions
80
Q

What are the top 3 in hierarchy for motor control?

A
  1. Primary Motor Cortex (M1)
  2. Supplementary Motor Cortex (SMA)
  3. Other Parts of the Parietal Cortex (e.g. premotor cortex)
81
Q

Where is the primary visual cortex?

A
82
Q

What brodmann area is this?

A
83
Q

What does the primary visual cortex (V1) do?

A
  • First receives visual information (input first arrives here)
84
Q

What happens if you have no primary visual cortex?

Unilateral or bilateral

A
  • Bilaterally –> no visual information can come in
  • Therefore cannot detect objects

NB: Interestingly they can still detect moving objects

NB: You cannot see without your cerebral cortex (specifically V1)

85
Q

Where does the information go after V1?

A
  • Information goes to V2 and other areas
  • To be analysed further
86
Q

What does it mean for the primary visual cortex (V1) to be retinotopic?

What does the posterior part (occipital) part do?

What does the anterior part do?

A
  • Map of the Retina can be mapped onto V1

Posterior Part (near occipital pole) –> MACULA REGION –> the middle region of the retina (most cones found) –> giving highest acuity

Anterior Part –> PERIPHERAL VISION –> where most rods found –> black & white & motion vision –> more sensitive region (fainter things can be seen here more - e.g. stars)

87
Q

What happens if you are bashed on the back of the head?

A
  • Damage Occipital (posterior part)
  • This is the macula region

NB: Anterior part is the black & white peripheral vision region in V1

88
Q

Which side is each area of V1 (primary visual cortex) responsible for?

A
  • Each V1 Hemisphere –> responsible for Contralateral Visual field from both eyes
  • (i.e. left hemisphere V1 is in charge of right visual field)
    *
89
Q

What happens if you have a lesion/pathology in one side of V1?

What about if both sides?

A
  • Lose V1 on one side –> causes loss of contralateral visual field for both eyes
  • Lose V1 on both sides –> causes you to see nothing –> this is ‘cortical blindness’
90
Q

What is damage to V1 more formally called?

A
  • Corticoblindness or Cortical Blindness
  • Blindsight

These people see nothing whilst having perfectly normal working eyes

They are consciously blind

91
Q

What is interesting about people who are ‘consciously blind’?

What kind of damage do they have?

A
  • Despite Losing Both V1 areas
  • They can guess what an object is (get it more right than if guessing completely)
  • Detect moving objects
  • This is when they have cortical blindness

They can detect things despite not consciously seeing them

This is due to a other pathways in the cerebral cortex which detect moving objects and vision which do not involve V1

This is called blindsight

92
Q

Where is V1?

A
  • Found within the calcirine sulcus
  • Cortex spills over the lips of the calcarine cortex
  • Area 17
93
Q

What are the areas around V1 called?

A
  • Visual Association Cortices (V2)
94
Q

Where is the primary auditory cortex?

A
  • Small Area
  • Just below lateral fissure
95
Q

Where is wenicke’s area?

A
  • Large Area
  • Only found in dominant hemisphere

(It is bigger than image shows)

96
Q

What is the primary auditory cortex in charge of?

A
  • Receiving hearing information from both ears
97
Q

Where is Wernicke’s Area found?

A
  • Sensory language area
  • Only found in the dominant hemisphere
98
Q

What 2 streams can visual information go down after V1?

A
  1. What stream
  2. Where stream
99
Q

What brodmann area is important for visually guided movements?

(What is visually guided movement?)

A
  • Area 7

Following movement of an object with eyes aiding you (e.g. driving behind another car)

100
Q

In what lobes is the ‘where’ and ‘what’ visual stream?

A
  • ‘What’ visual stream –> Temporal Lobe (identify objects)
  • ‘Where’ visual stream –> Parietal Lobe (if someone is infront of you or not)
101
Q

What is focal epilepsy?

What does it do?

A
  • Affects ability of people to know what the things they are seeing are
  • (Example - they would confuse a door with a tree)
  • Different parts of the visual association area are responsible for recognising different types of objects

NB: The brain combines where & why streams to get a full picture

102
Q

What lobe is important for recognition of things?

A
  • Done by areas in the Temporal Lobe
  • not by V1
103
Q

Why is the visually guided movement section of the brain well placed?

A
  • It is near the parietal lobe
  • This is where the ‘where’ stream of the visual association region (V2) is found
  • This is helpful as you can only move towards objects if you know where they are
104
Q

Where is the fusiform gyrus?

(what is the gyrus medial and lateral to it?)

A
  • Medial to it –> Parahippocampal Gyrus
  • Lateral to it –> Inferior Temporal Gyrus

It is on the underside of the temporal lobe

105
Q

Where is the FFA (Fusiform Face Area)?

A
  • Found within the Fusiform Gyrus
  • One of the areas responsible for recognising specific classes of objects
  • FFA responsible for recognising faces
  • Particularly strong FFA found on the right side (but present on both sides)
    *
106
Q

When is the FFA active?

A
  • Active bilaterally when identifying faces
107
Q

What lesion usually causes prosopagnosia?

A
  • Lesion of the Right Side (more so than left)
  • Lesions of the FFA
108
Q

What is prosopagnosia?

A
  • When someone cannot recognise peoples faces anymore
109
Q

What are the people with prosopagnosia like?

A
  • May wake up after a stroke and not recognise their spouses face anymore
  • Will still be able to recognise their body shape & voice
  • Face will be anonymous
110
Q

Which hemisphere are language areas present in?

A
  • Dominant Hemispheres
111
Q

What is the angular gyrus responsible for? (2 things)

Which hemisphere is it found in?

A
  1. Reading
  2. Writing

Found in the dominant hemisphere (general rule for language stuff)

112
Q

If there is a lesion of the angular gyrus, what are the 2 conditions called?

Does this lesion need to occur bilaterally, unilaterally, etc.?

A

Causes:

  • Alexia (loss of ability to read)
  • Agraphia (loss of ability to write)

Needs to occur in dominant hemisphere

113
Q

What is the left hemisphere usually dominant for?

A
  • Ability to Speak
  • Ability to Write
  • Understand Spoken Words
  • Understand Written Words
  • Broca’s area
114
Q

What is the right cerebral hemisphere usually dominant for?

A
  • Integration of certain sounds (other than spoken sounds - e.g. coughing, laughter, crying & melodies)
  • Tactile Stimuli
  • Visual Spatial Awareness
  • Wernicke’s Area
    *
115
Q

Give little known 4 functions of the parietal lobe?

A
  1. Stereognosis
  2. Arithmetic (sums)
  3. Constructional Ability (right side)
  4. Body Image
116
Q

What is the main sulcus of the parietal lobe?

A
  • Interparietal Sulcus
117
Q

Where is the handknob (hand area)?

A
  • This can be seen next to the intraparietal sulcus
  • It is in front of the sum/arithmetic area

NB: Interestingly it is close to the sum area. maybe to do with learning to count with digits to 10

118
Q

Which sulcus is the arithmetic/sum section close to?

A
  • Intraparietal Sulcus
119
Q

What is the pre-frontal cortex generally to do with?

A
  • Behaviour
120
Q

What patient is associated with the pre-frontal cortex?

A
  • Phineas Gage
121
Q

Where are the following found?

  • Limbic Cortex
  • Cingulate Gyrus
  • Parahippocampal Gyrus
  • Uncus
A
122
Q

Which arrow points to what?

A
123
Q

What does the septum pallucidum divide?

A
  • Lateral Ventricles
124
Q

What is the corpus callosum also called?

What does it do?

A
  • Great commisure of the brain
  • Connects the 2 hemispheres of the brain
125
Q

Down which fissure does the MCA (middle cerebral artery) go down?

A
  • Lateral Fissure
126
Q

What is the cerebral blood supply structure?

A
127
Q

Which cortical areas are supplied by the middle cerebral artery?

A
  • Runs along lateral fissure
  • Supplies the lateral (outer) surface
  • Doesn’t quite supply all of it (just misses out)
128
Q

What does the anterior & posterior cerebral arteries supply?

A
  • Together they supply all the medial surface
  • They overspill and supply edges of lateral surface
129
Q

What structures does the anterior cerebral artery supply?

A
  • All of medial surface of the frontal lobe
  • Much of the Parietal lobe
130
Q

What structures does the posterior cerebral artery supply?

A
  • Calcarine Sulcus
  • Fusiform Gyrus
  • Parahippocampal Gyrus
  • Uncus
  • Auditory Centre
  • Primary Visual Cortex + much of visual association cortex
131
Q

What lobe is lesioned here?

What would the effects be?

A
  • Occipital Lobe
  • Visual Problems (V1 affected so corticoblindness for left visual field
132
Q

What is a berry aneurysm?
Where are these usually found?

A
  • Pocket of blood vessel
  • Usually cerebral aneurysms are found on the circle of willis
133
Q

If a berry aneurysm ruptures, what will it cause?

A
  • Subarachnoid Haemorrhage
  • Blood in the CSF

Subarachnoid Space –> between arachnoid & pia mater

134
Q

Give two ways how to stop a cerebral aneurysm from rupturing?

A
  1. Clipping aneurysm (metal clip)
  2. Putting in metal ball to cause it to clot
135
Q

What are the pathologies of the brain seen in alzeihmer’s?

A
  1. Shrinkage of forebrain
  2. Expansion of sulci
  3. Shrinkage of gyri (lost brain tissue)
  4. Expansion of ventricle

Beta amyloid deposition (used to be though this caused the problem)

136
Q

What does ACh do to cortical activity?

A
  • Cholinergic supply to cerebral cortex causes an increase in cortical activity
137
Q

What nucleus releases cholinergic fibres all over the brain?

A
  • Nucleus Basalis of Meynert
138
Q

What happens to nucleus basilis of meynert in alzeihmer’s?

A
  • Degenerates early (usually supplies all the neocortex with ACh)
139
Q

Where is the Nucleus Basilis of Meynert found?

A
  • Lies above anterior perforated substance
  • Lies in the base of the forebrain
140
Q

What does the nucleus basalis of meynert do?

A
  • Supplies the neocortex with cholinergic fibres
  • Sends fibres all over the neocortex (cerebral cortex)