For Final Flashcards
Toxicity
the degree to which a chemical substance or a particular mixture of substances can damage an organism
can refer to the effect on a whole organism as well as the effect on a substructure of the organism (such as cell (cytotoxicity) and the liver (hepatoxicity)
Toxicology
the study of harmful effects of substances on the environment, humans, animal health (the science of safety)
harmful effects on living things
Ecotoxicology
impact of exposures on population/communities/ecosystems
central concept of toxicology is that the effects of a toxicant are …
…dose-dependent
Will someone definitely get sick if exposed to a harmful substance?
No
also there are periods in a person’s life when he or she may be more susceptible to chemicals
____ often determines the toxicity of a substance
the route of exposure
dermal, inhalation
“the dose makes the poison”
LD50
Toxicity can be measured by its effects on the target
The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration
LD50 figures are frequently used as a general indicator of a substance’s acute toxicity
A lower LD50 is indicative of increased toxicity
Usually determined by animal tests (sometimes conflated w the concept of mouse unit (MU)) (the amount of toxin required to kill a 20g mouse in 15 min)
usually expressed s the mass of substance administered per unit mass of test subject (typically as mg per body mass (usually kg))
*The choice of 50% lethality as a benchmark avoids the potential for ambiguity of making measurements in the extremes and reduces the amount of testing required…however this also means that LD50 is not the lethal dose for all subjects; some may be killed by much less while others survive doses far higher
Limitations of Measuring Toxicity
- lethal dosage often varies depending on the method of administration; for instance, many substances are less toxic when administered orally than when intravenously (opioid epidemic relevance)
- length of exposure (time)
- age/life stage of organism exposed
- LD50 somewhat unreliable and results may vary greatly between testing facilities due to factors such as the genetic characteristics of the sample population, animal species tested, environmental factors and mode of administration
- can be wide variability between species as well (what is safe for rats may not be for humans and vice versa)
Environmental Racism
used to describe environmental injustice that occurs within a racialized context both in practice and policy
“racial discrimination in environmental policy-making, the enforcement of regulations and laws, the deliberate targeting of communities of color for toxic waste facilities, the official sanctioning of the life-threatening presence of poisons and pollutants in our communities, and the history of excluding people of color from leadership of the ecology movements”
It is a form of systemic racism whereby communities of color are disproportionately burdened with health hazards through policies and practices that force them to live in proximity to sources of toxic waste - as a result these communities suffer greater rates of health problems attendant on hazardous pollutants
Bhopal Chemical Disaster
AKA Bhopal gas tragedy was a gas lead incident in 1984 at the Union Carbide India Limited Company
was a majority US owned company
over 500,000 exposed to methyl isocyanate (MIC) gas
caused by poor maintenance and insufficient safety protocols
few if any efforts at remediation have been enacted or enforced
2 decades after initial explosion:
4,000 gas victims required hospital treatment every day
reproductive health outcomes - birth defects, genetic abnormalitties, social relationship disruption
Remaining organochlorines: CNS impairment, thyroid, liver, kidney damage, eye irritation, skin, respiratory tract, endocrine disruption
Endemic toxins (remaining heavy metals): miscarriage, nervous system impairment, behavioral + learning impairment in children, digestive tract irritation, kidney damage, infertility
Bhopal Chemical Disaster
AKA Bhopal gas tragedy was a gas lead incident in 1984 at the Union Carbide India Limited Company
was a majority US owned company
over 500,000 exposed to methyl isocyanate (MIC) gas
caused by poor maintenance and insufficient safety protocols
few if any efforts at remediation have been enacted or enforced
2 decades after initial explosion:
4,000 gas victims required hospital treatment every day
reproductive health outcomes - birth defects, genetic abnormalitties, social relationship disruption
Remaining organochlorines: CNS impairment, thyroid, liver, kidney damage, eye irritation, skin, respiratory tract, endocrine disruption
Endemic toxins (remaining heavy metals): miscarriage, nervous system impairment, behavioral + learning impairment in children, digestive tract irritation, kidney damage, infertility
What is a syndemic or synergistic epidemic?
the aggregation of 2+ concurrent or sequential epidemics or disease clusters in a population w biological interactions, which exacerbate the prognosis and disease burden
develop under health disparity, caused by poverty, stress, or structural violence and are studied by epidemiologists and medical anthropologists concerned w public health, community healht, and the effects of social conditions on health
Superfund Sites
CERCLA is informally called superfund… the act allows the EPA to clean up contaminated sites…also forces the parties responsible for the contamination to either perform cleanups or eimburse the government for EPA-led cleanup work
Love Canal
Hooker Chemical co dumped toxic chemicals
in 1950s, site was sold to become a public school
lots of leukemia, birth defects, high morbidity + mortality rates
protests began in the 1970s
in 1988 the NY dept of health described love canal as “a national symbol of a failure to exercise a sense of concern for future generations”
Epidemiological Transition
a shift from infectious diseases to chronic noncommunicable diseases being the primary cause of deaths and disability in a population
Noncommunicable diseases (NCDs)
conditions that are not contagious
most noncommunicable conditions are chronic diseases that develop gradually and last for a long time
*the percentage of deaths from NCDs in a pop generally increases with economic growth
“diseases of affluence”
- false dichotomy since NCDs are the primary cause of disease burden in adult populations globally regardless of country income level
modifiable risk factors are thought to be responsible for at least two thirds of all worldwide deaths from these conditions
NCDs that can be prevented through behavior change are sometimes called lifestyle diseases
Self efficacy
an individuals confidence in their ability to successfully complete a difficult task
The Health Belief Model States that…
individual behavior change is a function of personal perceptions of the severity of the disease, their own susceptibility to it, and their likely benefits of adopting healthier behaviors as well as perceptions about the barriers to action and their own self-efficacy to enact change
cues to action are important for triggering behavior change
Examples of NCDs
Chronic Respiratory diseases (CRDs)
Asthma
Chronic Obstructive Pulmonary Disorder (COPD)
- bronchitis
- emphysema
diabetes
other top NCDs worldwide
Digestive diseases
liver and kidney disease
CRDs
chronic respiratory diseases = diseases of airway, bronchi, and lungs (doesnt include chronic TB nor lung cancer)
Asthma
chronic, but reversible inflammation of the airways, attacks can be fatal
increasingle linked to environmental pollution
COPD
a chronic progressive disease that limits airflow and causes shortness of breath and productive coughing
causes over 3 mil deaths annually
primary risk factor: tobacco use
two of the most common presentations of COPD are bronchitis and emphysema
Diabetes
Type 1: occurs when body does not produce enough insulin
- typically sudden onset in childhood
- people w type 1 are rarely overweight
Type 2: occurs when the body develops insulin resistance and stops responding appropriately to insulin even when the hormone is still being produced
- typically gradual onset in adulthood
- considered preventable
- “diabesity” since people w type 2 are usually overweight or obese
Gestational diabetes
Diabetes + its complications have become major causes of disability and premature death in high-income and middle-income countries
between 1980 and 2015 the global diabetes prevalence rate doubled from 4.7% to 8.5% after standardizing the 1980 rates to the age distribution in 2015
The prevalence is expected to continue to climb in the coming decades to 10.4% in 2040 as more people worldwide become obese
Example of Obesity Report Cards
in 2016, Arkansas instituted an obesity surveillance campaign
a state mandate that all public schools provide weights + measurements of their students to offer parents essential info about their childrens health
model in Arkansas is being used to create new programs in states like Ma and Wy