Food and nutrition in IBD Flashcards
Definition of IBD: the two types and similarities and differences
1) ulcerative colitis: affects only the colon, and is characterised by ‘shallow inflammation’ which occurs along long lengths of the colon
2) Crohn’s disease: affects anywhere from the mouth to the anus in trans-mural skip lesions, giving this ‘cobble-stoned’ affect
- they are both chronic relapse and remitting diseases
- they are both characterised by symptoms such as: abdominal cramping, blood loss, weight loss, loss of appetite
Incidence of IBD in the UK
- UC: 15.7/100,000
- CD: 10.2/100,000
- IBD: 28.6/100,000
- there has been an increase in incidence in 10-16 year olds of 94%, but a fall in incidence by 38% in those over 40 years
Aetiology of IBD: role of western diets, milk protein, saccharin/sucralose, emulsifiers, omega 6/omega 3
- IBD does have a greater prevalence in Western regions, and has been linked to consumption of highly processed foods
- milk protein: in rodent study, only developed colitis if fed milk fat. Theory is that sulphur-rich bile is needed to digest, which provides a good environment for pathogenic bacteria and causes dysbiosis and inflammation of the gut
- saccharin/sucralose: epi studies in the US have showed decreased incidence of IBD when saccharin limited. Theory is that sweeteners cause dysbiosis and lower beneficial bacteria which worsens gut integrity and inflammation
- emulsifiers: such as polysorbate 80 (icecream) or maltodextrin (cereals), in rat models they increase intestinal permeability and predispose to bacterial translocation
- omega 3/6: increased risk of CD and UC according to meta-analyses with greater intakes of omega 6, higher intakes of total fat and meat. high intakes of LA have been linked to 30% increase in UC. Higher intakes of omega 3 have been linked to a 77% lower risk of UC. Recommended to follow Mediterranean diet
Impact of IBD on nutritional status: hypercatabolism, nutrient malabsorption, anemia, increased GI losses, reduced nutrient intake, osteopenia/osteoporosis
- hypercatabolism: common in CD and in severe UC, due to increase in inflammatory cytokines
- nutrient malabsorption: more common in CD due to small bowel involvement, but may occur in US with mucosal disease. May be due to strictures, fistuales, resections, extensive disease, SBS
- anaemia: common in both if rectal bleeding
- increased GI losses: only in CD, due to vomiting, diarrhoea
- reduced nutrient intake: only in CD, most likely due to strictures causing obstruction and a lot of nausea and vomiting
- osteopenia/osteoporosis: common in both due to malnutrition and Ca + vitamin D deficiencies
Nutrient deficiencies in IBD: weight loss, Fe, folate, B12, Ca, vitamin D, magnesium, zinc- recommendations?
- weight loss: can occur across both, a lot of fear or foods and vomiting/diarrhoea
- Fe: common in both due to blood losses (recommend eating red meats where possible, and pairing non-haem sources with vitamin C and avoiding Ca supplements or tannins around meals)
- folate: common in both due to blood loss, and also long term use of MTX (similar structure to folate- competitive inhibitor)
- B12: common in both, due to poor dietary intake, or could be due to terminal ileum resection
- Ca: may be due to poor dietary intake (avoidance of dairy as a trigger) and use of corticosteroids (recommend 1000 mg/day- ideally through dietary sources)
- vitamin D: greater requirements (due to corticosteroids) and poor intake
- magnesium and zinc: common in both especially if watery diarrhoea, may be due to bacterial overgrowth causing malabsorption or extensive mucosal disease
- recommend routine supplementation as deficiencies do appear to be independent of BMI and disease activity
Dietary interventions: exclusive enteral nutrition (including ESPEN guidance)
- EN diet for 6-8 weeks recommended as 1L for children to avoid steroids (not recommended in adults as 1L due to steroids being more efficacious)
- no difference in literature on polymeric/peptide/elemental feeds to any is fine, but there MAY be better remission in lower fat feeds (<3g/1000kcal) but more trials needed
- as high as 60-80% remission rates are seen
- reasons for efficacy may be: removing food ‘antigens’, improving nutritional status, beneficial microbiome, anti-inflammatory effects (i.e. if have omega 3)
Dietary interventions: Partial liquid diets
- Idea to have 35-50% of kcals from EN and the rest from food (i.e. 900 kcal + 3 Ensures)
- more UK based research needed
Dietary interventions: LOFFLEX diet
- ‘low fat fibre-limited exclusion diet’
- list of foods which cause symptoms in >5% of CD patients after coming of EN diet- these are to be excluded
- examples: wheat, onion, coffee, corn, oats
Dietary interventions for functional “IBS” symptoms in IBD
- IBS symptoms experienced by 35-57% of the population
- low FODMAP (fermentable oligosaccharides disaccharides monosaccharides and polyols)- poorly digested CHO may cause luminal distention in the colon as bacteria digest
- studies suggest low-FODMAP reduces symptoms and symptom severity score of IBS, but it can decrease beneficial bacteria in the gut so may need to use a probiotic alongside
- may also want to do low FODMAP for 4-8 weeks, see if symptoms improve, then start reintroducing foods again
Dietary interventions: Crohn’s disease exclusion diet
- idea is that this removes all animal fats, dairy, gluten, emulsifiers (‘western’ diet)
- study in children showed that CDED versus EN alone caused remission in 75% versus 59% at 6 weeks, which changed to 75.6% and 45.1% at 12 weeks
Dietary interventions: Specific CHO diet
- theory that tricky to digest CHO end up being fermented by gut bacteria and contributing to symptoms
- allows: fruits and vegetables, nuts, fresh meat, honey butter, home made yoghurt
- not allowed complex CHO such as starches, lactose, sucrose
- some very small studies have suggested a reduction in disease activity and remission rates with this diet
Dietary interventions: semi-vegetarian diet
- plant-based eating, but much more focussed on the Japanese diet
- meat/fish only allowed once fortnight/once week
- 92% remission at 2 years in very small study versus 33% in omnivores
Dietary interventions: CD-TREAT (solid EN)
- food based dietary approach where foods have exactly the same composition as EN
- in healthy adults this form of eating was thought to be more acceptable than liquid EN
- children on CD-TREAT: 60% went into remission
- larger trial in the works