Fluoroquinolones

Question 1

FQs generations

Answer 1

1. Nor-
2. Cipro-, O-
3. Levo-, Gemi-, Moxi- (Respiratory FQs)

Question 2

FQ gen spectrum

Answer 2

1. UTI
2. Aerobic gr-, Atypic Pneumonia (H.inf, Morexella)
3. Less aerobic gr-, more gr+ cocci (S.pneumoniae, some Enterobacter, MRSA)

All Cidal

Question 3

FQs MOA

Answer 3

DNA gyrase inhibition

Question 4

Cipro

Use, Resistance, Kinetic, Clearance, Interactions, Side effect

Answer 4

• Urogenital, Resp, GI infections
• Topoisomerase not connecting
• Oral, IV, 4h
• Renal
• ِDiatomic Cations, 2h space w/ Ca++, Fe, Milk, Dairy, Antacids, Al
• GI, Neural, Tendonitis (C/I in pregnancy & children)