Fluid compartments Flashcards
What does hypertonic mean?
osmolarity of impermeant solutes greater outside than inside, water leaves and cell shrinks
What does hypertonic mean?
osmolarity of impermeant solutes greater inside than outside so cell swells as water moves in
Why do cells not burnst?
Na+ K+ ATPase maintains concentrations of Na+ ions low inside cell = no net movement of Na+ across movement as any Na that diffuses gets pumped back
Why may cells burst during tissue preservation?
Below 15 degrees storage:
ATPase stops and without oxygen through circulation there is little ATP to pump out Na+
Water follows sodium and swells cells
What is the University of Wisconsin solution used for?
Solution reducing hypothermic cell swelling.
There is a lack of Na+ and Cl- so no influx possible.
Presence of extracellular impermeant solutes and presence of starch. and has antioxidants
What is Colloid osmotic pressure - COP?
Osmotic pressure by high concentration of plasma proteins in capillary
What are the mechanisms behind hydrostatic Oedema?
High hydrostatic pressure due to blood pressure.
It pushes fluid out of the vessels. = accumulation of interstitial fluid
What is Elphantiasis caused by?
Parasitic worms block lymphatic vessels, preventing drainage
Examples of anions?
Proteins - highly negative charge
What is more acidic, plasma or the inside of cells?
Inside of cells
What cell changes will occur when:
Osmolarity - Osm
Osm(o) < Osm(i)
Osm(o) > Osm(i)
no change
increases / bursts
What is an osmole:
Number of moles of solute that contribute to the osmotic pressure of a solution
What does it mean is the osmolarity between the blood and intracellular compartment is identical?
No significant osmotic effect
What does tonicity depend on?
Tonicity: “Strength” of a solution
- cell membrane
- permeability
- composition
Concentrations of ion in the plasma?
Na+ are found at 150 mmo L-1
Cl- at 110mmol L-1,
K+ at 5 mmol L-1
free Ca2+ at 2 mmol
