Flu Drugs Flashcards
1
Q
MOA: inhibits replication of influenza A by inhibition of viral uncoating- M2 protein blocker (early step) and viral assembly of HA (late step) -> conformation change in HA during intracellular transport
Does not work for flu B
A
Amantadine
Rimantadine
Note: Amantadine is used for Parkinson’s treatment
2
Q
MOA: inhibits NA of influenza A & B, leading to impaired budding from infected cells
Inhaled
A
Zanamivir
Adverse: do not give in underlying lung disease
H5N1 resistance (avian flu)
3
Q
MOA: inhibition of NA of flu A and B, preventing budding of virions from infected cell
oral prodrug that is converted to the active form by the liver
A
Oseltamivir
Resistance: seasonal H1N1 but not 2009 H1N1
