flow in blood vessels Flashcards
blood pressure
controlled by homeostatic mechanisms that rely on pariforal resistance, that is the resistance offered by blood vessels
darcys law
describes flow as pressure difference/resistance of flow
flow resistance
largely determined by vascular diameter.
poisuelles law
according to this flow is determined and proportional to the fourth power of the radius of a small blood vessel
resistanc to flow can be altered by
local tissue factors
innervation
hormones
local wall stress
factors controlling flow are…
closely related to metabolism and injury
active hyperaemia
when tissues produce more metabolites,
consume more oxygen
produce a lower than normal pH
flow autoregulation
occurs locally as substances causing dilatation increase flow and are washed out
injury causes
local histamine release swell as other injury chemicals
inovation
Sympathetic nerves generally cause vasoconstriction of smooth muscle with notable exceptions when smooth muscle contains more beta-receptors, leading to vasodilatation.
Cholinergic nerves have almost no effect except in gastrointestinal vasculature.
Non cholinergic non-adrenergic nerves release VIP and NOX and are vasodilatory.