Flood Chapter 41 Power Points

Question 1

Gentamicin is best used for what type of microorganism ?

Answer 1

Active against P. aeruginosa and gram-negative bacilli

Question 2

What is Gentamycin toxic level ?

Answer 2

Toxic > 9 micrograms/mL

Question 3

Gentamycin penetrates what tissues best ?

Answer 3

pleural, ascetic, and synovial fluids in presence of inflammation

Question 4

Aztreonam other name

Answer 4

Azactam

Question 5

What is Aztreonam B-lactam antimicrobial property

Answer 5

It’s a monobactam antimicrobial that does not have the thiazolidine ring present in PCN and the dihydrothiazine ring found in cephalosporins.
its effect is Limited to gram negative activity

Question 6

Where Azactam absorbed ?

Where do you find it ?

Answer 6

Not absorbed from GI but have therapeutic blood levels with IM or IV use.
Found in the CSF

Question 7

what is Azactam Unique advantage ?

Answer 7

Unique advantage is the absence of any cross-reactivity between aztreonam and circulating antibodies of PCN or cephalosporin allergic patients.

Can replace aminoglycosides (in treatment of gram-negatives) because it combines the activity of aminoglycosides with low toxicity of the beta-lactam antimicrobials