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IHO Week 3 > Fitz- Drug properties you should know.... > Flashcards

Fitz- Drug properties you should know.... Flashcards

1
Q

Folate analogues

A

TREX

MethoTREXate

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2
Q

Antimetabolites

A

CIABINE/ARABINE

CapeCITABINE
FludARABINE

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3
Q

Platinum containing agents

A

cisPLATIN

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4
Q

Anthracycline antibiotics

A

RUBICIN

doxoRUBICIN

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5
Q

Nitrosourease

A

MUSINE

carMUSTINE

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6
Q

Taxnes

A

TAXEL

pacliTAXEL

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7
Q

Antibiotics

A

MYCIN

bleoMYCIN

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8
Q

Camptothecins

A

irinoTECAN

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9
Q

Vinca alkaloid

A

VINblastINE

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10
Q

What drugs inhibit DHFR and block nucleotide synthesis?

A

MTX

Pemetrexed

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11
Q

What drugs cause pseudofeedback inhibition of PNP and PRPP? What does this do?

A

6-MP and 6-TP

Blocks purine synthesis?

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12
Q

What drugs block thymidylate synthase? What does this do?

A

Capecitabine
5-FU
Pemetrexed

Blocks pyrimidine synthesis

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13
Q

What drugs block ribonucleotide reductase? What does this do?

A

Hydroxyurea
Fludarabine

Blocks generation of deoxyribonucleotides

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14
Q

What drugs inhibit DNA Pol? What does this do?

A

Cytarabine
Fludarabine
Gemcitabine

Blocks DNA synth

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15
Q

What drug is an anthracycline antibiotic? What does this do?

A

Doxorubicin

Intercalates DNA

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16
Q

What drug generates free radicals? What does this do?

A

Bleomycin

Strand breaks

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17
Q

What drug forms topo II-DNA complexes? What does this do?

A

Etoposide

strand breaks

18
Q

What drug inhibits topo I? What does this do?

A

Irinotecan

strand breaks

19
Q

What drug generates H202? What does this do?

A

Procarbazine

Dna strand breaks

20
Q

What drugs terminate spindle assembly? What does this do?

A

Vincristine
vinblastine

Disrupts spindle formation

21
Q

What drugs enhance spindle formation? What does this do?

A

Paclitaxel
Ixabepilone

Disrupts spindle formation

22
Q

What drugs cause renal toxicity?

A 
Carmustine
Cisplatin
Cyclophosmide
Lomustine
MTX
Vincristine
23
Q

What drugs cause hepatotoxicity?

A 
Asparaginase
Busulfan
Carmustine
Cyclophosphamide
6-MP
MTX
6-TG
24
Q

What drugs cause Neutotoxicity?

A 
L-asparagine
carmustine
cisplatin
cytarabine
etoposide
5-FU
ixabepilone
MTX
paclitaxel
procarbazine
vinblastine
vincristine
25
Q

What drugs cause cardiotoxicity?

A

CHF
Doxorubicin
Trastumab

26
Q

What drugs have the highest emetic potential?

A

Cisplatin and mechorethamine

27
Q

What drugs have the lowest emetic potential?

28
Q

What drug inhibits glutathione peroxidase?

A

Doxorubicine

29
Q

What protein is responsible for MDR?

A

p-glycoprotein–transports drug out of cell

30
Q

What drug inhibits guanylyl kinase?

31
Q

What drugs inhibit HGPRT?

32
Q

What take advantage of the mutated p53 gene product?

A

Alkylating agents

33
Q

What drug inhibits PRPP (1st committed step in purine synthesis)?

34
Q

What drugs inhibit PNP (1st step in purine synthesis)?

35
Q

What drug is activated by PMK?

A

5-FU

UMP to UDP

36
Q

What drugs inhibit robnucleotide reductase?

A

gemcitabine

hydroxurea

37
Q

What drug is dependent on thymidine phosphorylase?

A

capecitabine

convertes capecitabine to 5-FU

38
Q

Topo I?

A

Iriniotecan?

39
Q

Topo II?

A

Doxo

Etopo

40
Q

What drugs inhibit thymidylate synthase?

A

Capecitabine
5-FU
Premetrexed

41
Q

What drugs interact w/ tubulin?

A

Ixabepilone
paclitaxel
vinblastine
vincristine

42
Q

What drug is degraded by xanthine oxidase? What drug inhibits xanthine oxidase?

A

6-MP

Allopurinol

IHO Week 3 (13 decks)

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