Fitz- Drug properties you should know....

Question 1

Folate analogues

Answer 1

TREX

MethoTREXate

Question 2

Antimetabolites

Answer 2

CIABINE/ARABINE

CapeCITABINE
FludARABINE

Question 3

Platinum containing agents

Answer 3

cisPLATIN

Question 4

Anthracycline antibiotics

Answer 4

RUBICIN

doxoRUBICIN

Question 5

Nitrosourease

Answer 5

MUSINE

carMUSTINE

Question 6

Taxnes

Answer 6

TAXEL

pacliTAXEL

Question 7

Antibiotics

Answer 7

MYCIN

bleoMYCIN

Question 8

Camptothecins

Answer 8

irinoTECAN

Question 9

Vinca alkaloid

Answer 9

VINblastINE

Question 10

What drugs inhibit DHFR and block nucleotide synthesis?

Answer 10

MTX

Pemetrexed

Question 11

What drugs cause pseudofeedback inhibition of PNP and PRPP? What does this do?

Answer 11

6-MP and 6-TP

Blocks purine synthesis?

Question 12

What drugs block thymidylate synthase? What does this do?

Answer 12

Capecitabine
5-FU
Pemetrexed

Blocks pyrimidine synthesis

Question 13

What drugs block ribonucleotide reductase? What does this do?

Answer 13

Hydroxyurea
Fludarabine

Blocks generation of deoxyribonucleotides

Question 14

What drugs inhibit DNA Pol? What does this do?

Answer 14

Cytarabine
Fludarabine
Gemcitabine

Blocks DNA synth

Question 15

What drug is an anthracycline antibiotic? What does this do?

Answer 15

Doxorubicin

Intercalates DNA

Question 16

What drug generates free radicals? What does this do?

Answer 16

Bleomycin

Strand breaks

Question 17

What drug forms topo II-DNA complexes? What does this do?

Answer 17

Etoposide

strand breaks

Question 18

What drug inhibits topo I? What does this do?

Answer 18

Irinotecan

strand breaks

Question 19

What drug generates H202? What does this do?

Answer 19

Procarbazine

Dna strand breaks

Question 20

What drugs terminate spindle assembly? What does this do?

Answer 20

Vincristine
vinblastine

Disrupts spindle formation

Question 21

What drugs enhance spindle formation? What does this do?

Answer 21

Paclitaxel
Ixabepilone

Disrupts spindle formation

Question 22

What drugs cause renal toxicity?

Answer 22

Carmustine
Cisplatin
Cyclophosmide
Lomustine
MTX
Vincristine

Question 23

What drugs cause hepatotoxicity?

Answer 23

Asparaginase
Busulfan
Carmustine
Cyclophosphamide
6-MP
MTX
6-TG

Question 24

What drugs cause Neutotoxicity?

Answer 24

L-asparagine
carmustine
cisplatin
cytarabine
etoposide
5-FU
ixabepilone
MTX
paclitaxel
procarbazine
vinblastine
vincristine

Question 25

What drugs cause cardiotoxicity?

Answer 25

CHF Doxorubicin Trastumab

Question 26

What drugs have the highest emetic potential?

Answer 26

Cisplatin and mechorethamine

Question 27

What drugs have the lowest emetic potential?

Answer 27

Busulfan

Question 28

What drug inhibits glutathione peroxidase?

Answer 28

Doxorubicine

Question 29

What protein is responsible for MDR?

Answer 29

p-glycoprotein--transports drug out of cell

Question 30

What drug inhibits guanylyl kinase?

Answer 30

6-MP | 6-TG

Question 31

What drugs inhibit HGPRT?

Answer 31

6-MP | 6-TG

Question 32

What take advantage of the mutated p53 gene product?

Answer 32

Alkylating agents

Question 33

What drug inhibits PRPP (1st committed step in purine synthesis)?

Answer 33

6-MP | 6-TG

Question 34

What drugs inhibit PNP (1st step in purine synthesis)?

Answer 34

6-MP | 6-TG

Question 35

What drug is activated by PMK?

Answer 35

5-FU | UMP to UDP

Question 36

What drugs inhibit robnucleotide reductase?

Answer 36

gemcitabine | hydroxurea

Question 37

What drug is dependent on thymidine phosphorylase?

Answer 37

capecitabine | convertes capecitabine to 5-FU

Question 38

Topo I?

Answer 38

Iriniotecan?

Question 39

Topo II?

Answer 39

Doxo | Etopo

Question 40

What drugs inhibit thymidylate synthase?

Answer 40

Capecitabine 5-FU Premetrexed

Question 41

What drugs interact w/ tubulin?

Answer 41

Ixabepilone paclitaxel vinblastine vincristine

Question 42

What drug is degraded by xanthine oxidase? What drug inhibits xanthine oxidase?

Answer 42

6-MP | Allopurinol