First test Flashcards

1
Q

L1 - Learning objectives

  • Describe the major divisions of the nervous system
  • Identify/describe the major external and internal features of the spinal cord
  • Explain the consequences of spinal cord damage
A

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2
Q

Organization of Nervous System

The central nervous system (CNS) is the:

The peripheral nervous system (PNS) is the:

A

Organization of Nervous System

The central nervous system (CNS) is the:
- INTEGRATING and COMMAND centre

The peripheral nervous system (PNS) is the:
- COMMUNICATION system linking all parts of the body to the CNS, via NERVES

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3
Q

Major subdivisions of the CNS

BRAIN:

A

Major subdivisions of the CNS

BRAIN:

  • Cerebrum:
    • Cerebral Hemispheres
    • Diencephalon
  • Brainstem:
    • Midbrain
    • Pons - Hindbrain
    • Medulla Oblongata - Hindbrain
  • Cerebellum:
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4
Q
  • How much does the brain weigh?
  • The Cerebrum takes up what percentage of the brain volume?
  • What percentage of neurons does the cerebellum contain?
A
  • 15 kg
  • 83%
  • 50%
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5
Q

What is grey matter?

What is white matter?

A

What is grey matter?

  • (Neuron cell bodies)
  • Group of cell bodies =
    • Nucleus (CNS)
    • Ganglion (PNS)

What is white matter?

  • (myelinated Axons)
  • Bundle of axons =
    • Tract (CNS)
    • Nerve (PNS)
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6
Q

Brain section summary:

What are the sections?

A

Brain section summary:

What are the sections?

  • Axial (or Horizontal or Transverse)
    • Side to Side
  • Coronal
    • Top to Bottom
  • Sagittal
    • Front to Back
  • NOTE: there is also midsagittal
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7
Q

Orientation (direction): cerebrum
- Draw it L1, page 30

Orientation (direction): brainstem/spinal cord
- Draw it L1, page 31

A

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8
Q

Spinal Cord Anatomy

The spinal cord extends from the:

What is the width and length of the spinal cord?

How many pairs of spinal nerves?

What does the spinal cord provide?

A

Spinal Cord Anatomy

The spinal cord extends from the:
- Foramen magnum to 1st or 2nd lumbar vertebra

What is the width and length of the spinal cord?

  • Width of thumb
  • ~42cm long

How many pairs of spinal nerves?
- 31

What does the spinal cord provide?
- Provides TWO-WAY street of information to and from the brain

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9
Q

What are the 31 pairs of spinals nerves?

A

What are the 31 pairs of spinals nerves?

  • 8 cervical spinal nerves
  • 12 thoracic spinal nerves
  • 5 lumbar spinal nerves
  • 5 sacral spinal nerves
  • 1 Coccygeal spinal nerves
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10
Q

What are the two enlargements where nerves for upper and lower limbs arise?

A

What are the two enlargements where nerves for upper and lower limbs arise?

  • Cervical enlargement
  • Lumbar enlargement
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11
Q

What is the structure of the Conus medullaris (medullary cone)?

Where is the conus medullaris located?

What does the Conus medullaris allow?

A

What is the structure of the Conus medullaris (medullary cone)?
- Tapering conical structure

Where is the conus medullaris located?
- Below the lumbar enlargement

What does the Conus medullaris allow?
- Allows the filum terminale (terminal filum) to anchor the spinal cord to the coccyx (tail bone)

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12
Q

Cauda equaina (horse tail)

Roots of the nerves that arise from the?

A

Cauda equaina (horse tail)

Roots of the nerves that arise from the?
- Lumbar, sacral & coccygeal regions of the spinal cord and travel down the verebral column

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13
Q

Draw and label a transverse cross-section of a spinal cord

- Lecture 1, page 37

A

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14
Q

Spinal cord - Grey Matter

Posterior (dorsal) horns:

Anterior (ventral) horns:

A

Spinal cord - Grey Matter

Posterior (dorsal) horns:
- incoming terminals from peripheral sensory neurons + interneurons

Anterior (ventral) horns:
- Motor neurons that go to the periphery + interneurons

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15
Q

Spinal Cord - Sensory Input & Motor Output

Draw
- L1, Page 41

A

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16
Q

Spinal cord - White matter

What are the columns?
- Draw them

A

Spinal cord - White matter

What are the columns?

  • Lateral columns
  • Posterior (dorsal) columns
  • Anterior (ventral) columns
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17
Q

Comparing Cross-section of Spinal Cord

  • Draw, L1, page 43
  • Where is there enlarged grey matter?
    What does this mean?
A

Comparing Cross-section of Spinal Cord

Where is there enlarged grey matter?
- In cervical and Lumbar regions

What does this mean?
- More neurons are supplying muscles of upper (cervical) and lower (lumbar) limbs

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18
Q

Comparing Cross-section of Spinal Cord

What does white matter increase in?

What does this reflect?

A

Comparing Cross-section of Spinal Cord

What does white matter increase in?
-Increases in dorsal columns from lumbar to cervical regions

What does this reflect?
- Reflects increasing addition of sensory fibres from caudal to rostral truck regions

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19
Q

Spinal Cord Injury (SCI)

Paralysis?

Paraesthesia?

A

Spinal Cord Injury (SCI)

Paralysis?
- Loss of motor function

Paraesthesia?
- Sensory loss

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20
Q

Lecture 2 objectives

  • Identify the ventricular system and describe the circulation/drainage of CSF
  • Recognize the external surface features of the brain
  • Identify/describe the three layers of meninges and their specializations
  • Explain the clinical significance of meninges and the ventricular system
A

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21
Q

Ventricular System

Brain:

Spinal Cord:

Contains?

A

Ventricular System

Brain:
4 ventricles
- Lateral (2)
- Third
- Fourth

Spinal Cord:
- Central Canal

Contains?
- CSF

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22
Q

Ventricular system

- Have a look at L2, page 4

A

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23
Q

Cerebrospinal Fluid (CSF)

Clear liquid (modified plasma) produced by … …. in each ventricle

Fills …. ….. & ….. ….., as well as the …. ….

Drained into … …. through the …. …..

Sampling of CSF - …. …..

A

Cerebrospinal Fluid (CSF)

Clear liquid (modified plasma) produced by CHOROID PLEXUS in each ventricle

Fills CEREBRAL VENTRICLES & SPINAL CANAL, as well as the SUBARACHNOID SPACE

Drained into VENOUS SINUS through the ARACHNOID GRANULATIONS

Sampling of CSF - LUMBAR PUNCTURE

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24
Q

Communication/Continuity of Ventricles

What are the small openings or channels?

A

Communication/Continuity of Ventricles

What are the small openings or channels?

  • Cerebral aqueduct
  • Interventricular foramen
  • Lateral aperature
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25
Lateral Ventricles: Is a Body + 3 horns What are the three horns? Where does the choroid plexus?
Lateral Ventricles: Is a Body + 3 horns What are the three horns? - Anterior horn - Inferior horn - Posterior horn Where does the choroid plexus? - Body & inferior horn
26
Third Ventricle - Between? - Where is the choroid plexus?
Third Ventricle Between? - Lateral ventricle and cerebral aqueduct Where is the choroid plexus? - In roof
27
Fourth Ventricle Roof formed by? Floor formed by?
Fourth Ventricle Roof formed by? - Superior medullary velum - Inferior medullary velum (Choroid plexus) Floor formed by? - Brainstem
28
Fourth Ventricle Lies between? Three openings?
Fourth Ventricle Lies between? - Cerebellum - pons & medulla Three openings? - 2 lateral apertures - Foramina of Luschka - 1 median aperature - Foramen of Magendie
29
Flow of CSF
Flow of CSF 1) Choroid plexus 2) Third ventricle 3) Mesencephalic aqueduct 4) Lateral aperture 5) Median aperture 6) Central canal of spinal cord 7) Subarachnoid space of spinal cord 8) Superior sagittal sinus 9) Arachnoid villus 10) Subarachnoid space
30
External features of the Brain - Gyri/Sulci Gyri = Sulci = Fissure:
External features of the Brain - Gyri/Sulci Gyri = Hill tops - Singular form - gyrus Sulci = Valleys - Singular form - sulcus Fissure: - Separates large regions of the brain
31
Superior Surface of the brain Kinda draw L2, Page 17 What lobes? What sulcus?
Superior Surface of the brain What lobes? - Frontal - Parietal - Occipital What sulcus? - Central sulcus
32
Lateral Surface Kinda draw L2, Page 18 What lobes? What sulcus? What fissure?
Lateral Surface What lobes? - Occipital lobe - Parietal lobe - Frontal lobe - Temporal lobe What sulcus? - Lateral - Central What fissure? - Transverse fissure which separates the cerebrum from the cerebellum
33
Medial Surface What lobes? What sulcus? What fissure? What else can you see?
Medial Surface What lobes? - Parietal - Occipital What sulcus? - Parieto-occipital sulcus What fissure? - Transverse What else can you see - Diencephalon - Cerebellum - Brainstem
34
ventral Surface What lobes? What else can you see? What is it best for?
ventral Surface What lobes? - Frontal - Temporal What else can you see? - Brainstem - Cerebellum What is it best for? - Best view for cranial nerves & blood vessels
35
Insula Cortex - Insula Buried w/in? and forms what? Covered by portions of what lobes?
Insula Cortex - Insula Buried w/in? and forms what? - Buried deep w/in the lateral sulcus & forms part of its floor Covered by portions of what lobes? - temporal - Parietal - Frontal
36
Test Yourself - Lecture 2, page 22
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37
Meninges Protection of? What are the three layers?
Meninges Protection of? - The brain and spinal cord What are the three layers? - Dura mater (external) - Arachnoid mater (middle) - Pia mater (inner)
38
External Meninge: Dura Mater (tough mother) Thick layer of? VERY tough providing?
External Meninge: Dura Mater (tough mother) Thick layer of? - Connective tissue surrounding the brain VERY tough providing? - Main support and protection
39
Dura Mater: two layers What are the two layers? The two layers of dura mater separate and form large dural .....?
Dura Mater: two layers What are the two layers? - Periosteal - Meningeal The two layers of dura mater separate and form large? - Venous sinuses
40
Dura Mater: Meningeal Layer Folds Extends ... to form partitions - Subdivide the cranial cavity - Limit excessive movement of the brain within the cranium Forms a .... between: Two cerebral hemispheres ... .... Cerebellum & cerebrum ..... ..... Two cerebellar hemispheres .... ......
Dura Mater: Meningeal Layer Folds Extends INWARDS to form partitions - Subdivide the cranial cavity - Limit excessive movement of the brain within the cranium Forms a PARTITION between: Two cerebral hemispheres FALX CEREBRI Cerebellum & cerebrum TENTORIUM CEREBELLI Two cerebellar hemispheres FALX CEREBELLI
41
Falx Cerebri Lies in: Partially separates: Attaches to a bony projection: Attaches to upper surface of?
Falx Cerebri Lies in: - Median sagittal plane (in longitudinal fissure) Partially separates: - Cerebral hemispheres Attaches to a bony projection: - Crista galli (roosters crest), anteriorly Attaches to upper surface of? - Tentorium cerebelli in the midline, posteriorly
42
Tentorium cerebelli What plane? Separates?
Tentorium cerebelli What plane? - Horizontal plane Separates? - Separates cerebrum from cerebellum
43
Falx Cerebelli What fold? Separates?
Falx Cerebelli What fold? - Smaller dural fold runs along the vermis of the cerebellum Separates? - Separates two cerebellar hemispheres
44
Subdural Space What is subdural space? Structure? What can cause enlargement?
Subdural Space What is subdural space? - The space bw meningeal dura mater & arachnoid mater Structure? - Very narrow, contains a film of fluid What can cause enlargement? - May be enlarged by bleeding (= subdural haemorrhage/hematoma)
45
Middle Meninge: Arachnoid Mater (arachnida = spider) Describe the membrane: Connected to the?
Middle Meninge: Arachnoid Mater (arachnida = spider) Describe the membrane: - Delicate transparent membrane (does not dip into sulci) Connected to the? - Connected to the pia mater by fine strands of connective tissue (ARACHNOID TRABECULA)
46
Subarachnoid space Space between? Structure? Contains? Bleeding results in?
Subarachnoid space Space between? - Between the arachnoid mater and pia mater Structure? - Wide space, filled w/ cerebrospinal fluid (CSF) - watery "cushion" Contains? - Blood vessels (poorly protected) Bleeding results in? - Results in blood in the CSF (subarachnoid haemorrhage)
47
What is a Cisterna?
What is a Cisterna? | - An enlarged Subarachnoid Space
48
Arachnoid Villi & Granulations Arachnoid Villi: Arachnoid Granulations:
Arachnoid Villi & Granulations Arachnoid Villi: - Knob-like projections of the arachnoid mater Arachnoid Granulations: - Collections of arachnoid villi - Drain CSF into venous sinuses
49
Inner Meninge: Pia mater (gentle mother) Sends prolongations into brain tissue along with blood vessels (forming .... ....) Helps form the roof of the ventricles, closely associated with .... .... & .....
Inner Meninge: Pia mater (gentle mother) Sends prolongations into brain tissue along with blood vessels (forming PERIVASCULAR SPACE) Helps form the roof of the ventricles, closely associated with CHOROID PLEXUS & EPENDYMA
50
Can you recognize Dural Meninge Layers L2, page 39
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51
Spinal Meninges There is no?
Spinal Meninges There is no? - NO dural periosteal layer
52
Spinal Meninges: Epidural Space Between? Contains? Largest at?
Spinal Meninges: Epidural Space Between? - B/w spinal dural sheath and vertebral bony wall Contains? - Fat tissue & venous plexus Largest at? - L2
53
Spinal Meninges: Subarachnoid Space Between? Contains?
Spinal Meninges: Subarachnoid Space Between? - B/w the arachnoid and pia mater meninges Contains? - Cerebrospinal fluid (CSF)
54
What is a Lumbar Cistern? Where?
What is a Lumbar Cistern? - Enlarged Subarachnoid Space Where? - Caudal to spinal cord (below L2)
55
Spinal Meninges: Pia Mater Specializations What specializations?
Spinal Meninges: Pia Mater Specializations What specializations? - Denticulate ligament - triangular shaped: supports spinal cord w/in dural sheath - Filum Terminale
56
Meningitis Characterized by? Most common infection of? Usually caused by? Common symptoms? Diagnosis? Treatment?
Meningitis Characterized by? - Inflamation of the pia-arachnoid mater Most common infection of? - The CNS Usually caused by? - Bacterium or a virus Common symptoms? - Fever, headache, vomiting and stiff neck Diagnosis? - Performing a lumbar puncture, examining the CSF Treatment? - Antibiotics quickly, to prevent infection spreading across pia mater to injure neurone in brain
57
Meninges Trive L2, page 47
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58
Human Embryo Develops into two-layered embryonic disc after how many days after fertilization? What layer gives rise to the nervous system?
Human Embryo Develops into two-layered embryonic disc after how many days after fertilization? - 11 days What layer gives rise to the nervous system? - Embryonic ectoderm
59
CNS Development (19-20 days) Draw the dorsal surface & Transverse section on L3, page 4 The entire nervous system arises from? The ectoderm thickens to form the? The neural plate gives rise to neural folds and the?
CNS Development (19-20 days) The entire nervous system arises from? - Embryonic ectoderm The ectoderm thickens to form the? - Neural plate The neural plate gives rise to neural folds and the? - Neural groove
60
CNS Development (22-26 days) Neural crest gives rise to? The neural plate folds inward to form the? Epithelial cells lining the neural tube generate all the?
CNS Development (22-26 days) Neural crest gives rise to? - Neurons destined to reside in ganglia The neural plate folds inward to form the? - Neural tube Epithelial cells lining the neural tube generate all the? - Neurons of the CNS
61
Neural Tube The rostral portion forms the? The caudal portion forms the? The cavity forms the?
Neural Tube The rostral portion forms the? - Brain The caudal portion forms the? - Spinal cord The cavity forms the? - Ventricular system
62
Neural Tube Defects Anencephaly (without brain): Failure of?
Neural Tube Defects Anencephaly (without brain): Failure of? - Failure of the rostral neural folds to fuse rostrally
63
Neural Tube Defects Spina Bifida (forked spine): What fails to close?
Neural Tube Defects Spina Bifida (forked spine): What fails to close? - The caudal portion of the neural tube fails to close
64
Spinal cord development (week 6) Draw L3, page 9
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65
Embryonic Development of Human Brain Draw table on L3, page 10
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66
Brain development At 5 weeks what has developed? At 13 weeks what has developed? At birth what remains prominent? What else occurs?
Brain development At 5 weeks what has developed? - Telencephalon - Diencephalon - Mesencephalon - Metencephalon - Myelencephalon - Spinal cord At 13 weeks what has developed? - Cerebral hemisphere - Outline of diencephalon - Midbrain - Cerebellum - Pons - Medulla oblongata - Spinal cord At birth what remains prominent? - Cephalic flexure (midbrain level) What else occurs? - Convolutions - increase the surface area of the brain
67
CNS Development What area is the last to develop?
CNS Development What area is the last to develop? - Prefrontal areas
68
Blood supply of the brain What percentage of blood flow does the brain receive? What percentage of the body's oxygen and glucose does the brain consume How long of an interruption to blood flow will cause unconsciousness? How long of an interruption to blood flow will cause impaired neural function? How long of an interruption to blood flow will cause irreversible brain damage?
Blood supply of the brain What percentage of blood flow does the brain receive? - 15% (~750 mL/min) What percentage of the body's oxygen and glucose does the brain consume - 20% How long of an interruption to blood flow will cause unconsciousness? - 10 seconds How long of an interruption to blood flow will cause impaired neural function? - 1-2 minutes How long of an interruption to blood flow will cause irreversible brain damage? - 4 minutes
69
What are the Cerebral Arteries?
What are the Cerebral Arteries? - Basilar Artery - Internal Carotid artery
70
What are the Cerebral Arteries?
What are the Cerebral Arteries? - Basilar Artery - Internal Carotid artery - Vertebral arteries
71
Cerebral arteries: The basilar artery divides into two?
Cerebral arteries: The basilar artery divides into two? - Posterior cerebral arteries
72
Cerebral Arteries: The internal carotid artery branches into?
Cerebral Arteries: The internal carotid artery branches into? - Anterior & middle cerebral arteries
73
Circle of Willis What does the posterior cerebral artery connect to? Maintains blood supply to entire brain if?
Circle of Willis What does the posterior cerebral artery connect to? - Posterior cerebral artery connects to internal carotid artery via posterior communicating arteries, & along with anterior cerebral arteries Maintains blood supply to entire brain if? - 1 artery is having problems
74
Posterior Cerebral Artery Supplies?
Posterior Cerebral Artery Supplies? - Medial aspect of the hemisphere (posterior 1/3), occipital lobes, inferior temporal lobe regions, brainstem, 3rd and lateral ventricles
75
Anterior Cerebral Artery Supplies?
Anterior Cerebral Artery Supplies? - Medial aspects of cerebral hemisphere (anterior 2/3 only) & basal nuclei
76
Middle cerebral Artery Supplies?
Middle cerebral Artery Supplies? - Almost all the lateral surface of cerebral hemisphere
77
Blood-Brain Barrier (BBB) Formed by? Selective for? Keeps out? Ineffective against?
Blood-Brain Barrier (BBB) Formed by? - Tight junctions b/w endothelial cells of cerebral capillaries Selective for? - Nutrients (glucose, essential aa & electrolytes Keeps out? - Large molecules, certain chemicals and drugs Ineffective against? - Fats, fatty acids, and fat-soluble
78
Stroke-related dysfunction Anterior cerebral artery: Middle cerebral artery (most common stroke): Posterior cerebral artery:
Stroke-related dysfunction Anterior cerebral artery: - Contralateral hemiplegia (one artery) or bilateral paralysis (two arteries) & impaired sensation - Greatest in the lower limb Middle cerebral artery (most common stroke): - A severe contralateral hemiplegia & impaired sensation - Most marked in the upper limb & face - Severe aphasia (language deficit) if the dominant hemisphere is affected Posterior cerebral artery: - Contralateral homonymous hemianopsia (visual loss in half the visual field in both eyes)
79
What is the Blood drainage of the brain?
What is the Blood drainage of the brain? Fine veins (brain) > pial venous plexuses What is the Blood drainage of the brain > cerebral veins > dural venous sinuses > internal jugular vein > Heart
80
Emissary Veins Blood from where drain venous sinuses? Potential source of? Rupture =?
Emissary Veins Blood from where drain venous sinuses? - Blood from scalp and facial skin around the nose and upper lip drain venous sinuses Potential source of? - Infection into the cranial cavity Rupture =? - Subdural hematoma
81
Venous sinuses B/w? Receive venous blood from? Receive?
Venous sinuses B/w? - Two layers of dura mater Receive venous blood from? - Brain and scalp Receive? - CSF
82
Draining the Superior & Deep structures 1) Superior sagittal sinus lies along the? Joins the? Arachnoid villi drain?
Draining the Superior & Deep structures 1) Superior sagittal sinus lies along the? - Superior margin of the falx cerebri Joins the? - Transverse sinus Arachnoid villi drain? The CSF into the superior sagittal sinus
83
Draining the Superior & Deep Structures 2) Inferior sagittal sinus Lies along? Joins?
Draining the Superior & Deep Structures 2) Inferior sagittal sinus Lies along? - The inferior margin of the falx cerebri Joins? - Straight sinus
84
Draining the Superior & Deep Structures 3) Straight Sinus w/in? Joins?
Draining the Superior & Deep Structures 3) Straight Sinus w/in? - tentorium cerebelli Joins? - Left transverse sinus
85
Draining the Superior & Deep Structures 4) Transverse sinus Left continuous with? Right continuous with?
Draining the Superior & Deep Structures 4) Transverse sinus Left continuous with? - Straight sinus Right continuous with? - Superior sagittal sinus
86
Draining Superior & Deep Structures 5) Sigmoid sinus Forward continuation of? Opens into?
Draining Superior & Deep Structures 5) Sigmoid sinus Forward continuation of? - transverse sinus Opens into? - Internal jugular vein
87
Draining the Inferior Structures 6) Cavernous sinus Lateral to? Drains into?
Draining the Inferior Structures 6) Cavernous sinus Lateral to? - Pituitary gland, linked with VENOUS CHANNELS Drains into? - Superior (TRANSVERSE sinus) & Inferior petrosal (INTERNAL JUGULAR V) sinuses
88
Summary on L3, page 42
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89
name the sinuses L3, page 43
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90
Spinal Cord Blood Supply What descends to spinal cord? Spinal arteries branch into?
Spinal Cord Blood Supply What descends to spinal cord? - Vertebral artery ``` Spinal arteries branch into? - Posterior - Anterior - Radicular arteries ```
91
Blood supply to the Spinal Cord Anterior spinal arteries supply? Posterior spinal arteries supply? Radicular arteries supply?
Blood supply to the Spinal Cord Anterior spinal arteries supply? - Anterior (ventral) and lateral columns, gray matter (except for the dorsal horns) Posterior spinal arteries supply? - Posterior (dorsal) horns and posterior (dorsal) columns Radicular arteries supply? - The spinal nerves
92
Spinal Cord Blood Drainage Anterior and posterior spinal veins drain blood into the?
Spinal Cord Blood Drainage Anterior and posterior spinal veins drain blood into the? - internal vertebral venous plexus
93
Spinal Cord Stroke What percentage of all strokes? Typically? Symptoms depend on?
Spinal Cord Stroke What percentage of all strokes? - 1-2% Typically? Ischemic Symptoms depend on? - Blood vessel and level of spinal cord affected
94
L4 learning objectives - Identify the external features of each cerebral lobe - Explain the general functions of each cerebral lobe - Identify the cortical regions involved in producing and controlling the following functions - Movement - General sensory perception - Vision - Auditory info - Language - Describe the consequences of damage to the structures identified above
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95
What are Motor areas? What are Sensory areas? What are association areas? Conscious behaviour involves?
What are Motor areas? - Voluntary motor functions What are Sensory areas? - Conscious awareness of sensation What are association areas? - Integrating diverse information for purposeful action Conscious behaviour involves? - The entire cortex
96
Functions of Lobes of the Cerebrum: FRONTAL lobe The frontal lobe contains? What are the Frontal lobe gyri?
Functions of Lobes of the Cerebrum: FRONTAL lobe The frontal lobe contains? - Contains voluntary motor functions and areas for language, planning, mood/personality, social judgement and smell What are the Frontal lobe gyri? - Superior frontal gyrus - Middle frontal gyrus - Inferior frontal gyrus
97
Frontal Lobe - Precentral Gyrus (Primary Motor Cortex): Controls skilled voluntary movements of? What muscles does it control? The motor innervation of the body is?
Frontal Lobe - Precentral Gyrus (Primary Motor Cortex): Controls skilled voluntary movements of? - Skeletal muscles - Supplying about 30% of axons to corticospinal tract What muscles does it control? - Controls muscles in body areas having the most precise motor control - the face, tongue & hands The motor innervation of the body is? - Contralateral
98
Frontal lobe - Precentral gyrus (Primary Motor Cortex) What is Motor Homunculus? What is Somatotopy? Area of cortex related to specific region is proportional to? Each pyramidal neuron projects its axon to?
Frontal lobe - Precentral gyrus (Primary Motor Cortex) What is Motor Homunculus? - Little person What is Somatotopy? - Mapping of body area to brain regoin Area of cortex related to specific region is proportional to? - The amount of motor control over that region Each pyramidal neuron projects its axon to? - Spinal cord
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Anterior Cerebral Artery Supplies?
Anterior Cerebral Artery Supplies? - The MEDIAL aspect of cerebral hemispheres (anterior 2/3 only) & basal nuclei
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Middle Cerebral Artery Supplies?
Middle Cerebral Artery Supplies? - Supplies almost all the LATERAL surface of cerebral hemispheres
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Frontal Lobe - Precentral Gyrus (Primary Motor Cortex - DAMAGE Occlusion/rupture of a branch of the ANTERIOR cerebral artery: Occlusion/rupture of a branch of the MIDDLE cerebral artery:
Frontal Lobe - Precentral Gyrus (Primary Motor Cortex - DAMAGE Occlusion/rupture of a branch of the ANTERIOR cerebral artery: - Contralateral hemiplegia - Greatest in LOWER limbs Occlusion/rupture of a branch of the MIDDLE cerebral artery: - Contralateral hemiplegia - Greatest in UPPER limbs & FACE regions
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Frontal Lobe - Inferior Frontal Gyrus: What makes up the Inferior Frontal Gyrus?
Frontal Lobe - Inferior Frontal Gyrus: What makes up the Inferior Frontal Gyrus? - Opercular } Brocas - Triangular } Brocas - Orbital
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Frontal Lobe - Brocas Area What parts of the inferior frontal gyrus? Generates motor program for? Transmits to primary cortex for? Becomes active when? Present in?
Frontal Lobe - Brocas Area What parts of the inferior frontal gyrus? - Opercular - Triangular Generates motor program for? - Larynx, tongue, cheeks & lips for speech production Transmits to primary cortex for? - Action Becomes active when? - Preparing to speak Present in? - One hemisphere only (usually the left)
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Frontal Lobe - Brocas Areas Damage to Brocas area =? Difficulty generating? Comprehension generally?
Frontal Lobe - Brocas Areas Damage to Brocas area =? - Expressive (non-fluent) aphasia - Aphasia = language impairment Difficulty generating? - Written and spoken words Comprehension generally? - Intact
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Functions of Lobes of the Cerebrum: PARIETAL lobe Contains areas for?
Functions of Lobes of the Cerebrum: PARIETAL lobe Contains areas for? - Sensory reception and integration of sensory info, some languange and mathematic functions
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What are the two lobules of the parietal lobe?
What are the two lobules of the parietal lobe? - Superior parietal lobule - Inferior parietal lobule
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Parietal Lobe - Postcentral Gyrus (Primary Somatosensory Cortex) SENSORY HOMUNCULUS The area of the cortex dedicated to the sensations of various body parts is proportional to: Receives sensory info from? What is Spatial discrimination?
Parietal Lobe - Postcentral Gyrus (Primary Somatosensory Cortex) SENSORY HOMUNCULUS The area of the cortex dedicated to the sensations of various body parts is proportional to: - How sensitive that part of the body is Receives sensory info from? - Contralateral side What is Spatial discrimination? - Neurons can identify the body region being stimulated
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Parietal Lobe - Postcentral Gyrus (Primary Somatosensory Cortex) DAMAGE Occlusion/rupture of a branch of the ANTERIOR cerebral artery: Occlusion/rupture of a branch of the MIDDLE cerebral artery:
Parietal Lobe - Postcentral Gyrus (Primary Somatosensory Cortex) DAMAGE Occlusion/rupture of a branch of the ANTERIOR cerebral artery: - Contralateral sensory loss - Greatest in LOWER limbs Occlusion/rupture of a branch of the MIDDLE cerebral artery: - Contralateral sensory loss - Greatest in UPPER limbs & FACE regions
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Parietal Lobe - Superior Parietal Lobule (Somatosensory Association Cortex) Integrating different sensory inputs (relayed by the primary somatosensory cortex) to produce a comprehensive understanding of? What is DAMAGE (middle cerebral artery): TACTILE AGNOSIA:
Parietal Lobe - Superior Parietal Lobule (Somatosensory Association Cortex) Integrating different sensory inputs (relayed by the primary somatosensory cortex) to produce a comprehensive understanding of? - Position of limbs - Location of touch or pain - Shape, weight & texture of an object What is DAMAGE (middle cerebral artery): TACTILE AGNOSIA: - Unable to recognize objects w/out looking at them - (agnosia = inability to recognize)
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Parietal Lobe - Inferior Parietal Lobule (Multimodal Association Cortex) What gyri does it comprise of? Processes different kinds of stimuli (auditory, visual, sensormotor, etc) simultaneously for: DAMAGE (middle cerebral artery):
Parietal Lobe - Inferior Parietal Lobule (Multimodal Association Cortex) What gyri does it comprise of? - Supramarginal - Angular Processes different kinds of stimuli (auditory, visual, sensormotor, etc) simultaneously for: - Understanding the multiple properties of spoken and written words - Classifying and labeling things - Mathematic ability DAMAGE (middle cerebral artery): Agnosia, sensory neglect, dysgraphia (writing deficits), dyslexia, (reading deficits), dyscalculia (mathematic deficits)
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Functions of Lobes of the Cerebrum: TEMPORAL lobe Contains areas for?
Functions of Lobes of the Cerebrum: TEMPORAL lobe Contains areas for? - Hearing, smell, learning, memory, language & emotional behaviour
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Temporal Lobe What gyri? What Sulci?
Temporal Lobe What gyri? - Superior temporal gyrus - Middle temporal gyrus - Inferior temporal gyrus What Sulci? - Superior temporal sulcus - Inferior temporal sulcus
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Temporal Lobe - Primary Auditory Cortex Superior margin of the? Processes? Sensitive to? Unilateral damage (MIDDLE cerebral artery) = Bilateral damage =?
Temporal Lobe - Primary Auditory Cortex Superior margin of the? - Superior temporal gyrus Processes? - Auditory info Sensitive to? - Pitch, rhythm & loudness ``` Unilateral damage (MIDDLE cerebral artery) = - Hearing loss ``` Bilateral damage =? - Cortical deafness
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Temoral Lobe - Wernicks Area Auditory Association Cortex Posterior part of the? Sensory? Permits recognition of? Creates?
Temoral Lobe - Wernicks Area Auditory Association Cortex Posterior part of the? - Superior Temporal Gyrus Sensory? - Sensory language area Permits recognition of? - Spoken & written language Creates? - Plan of speech
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Temporal Lobe - Wernickes Area Damage to wernickes area =?
Temporal Lobe - Wernickes Area Damage to wernickes area = Receptive (fluent) aphasia - Speech normal & excessive, but makes little sense - No understanding of the meanings of words nor able to repeat them
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Damage to arcuate fasciculus = ?
Damage to arcuate fasciculus = Associative (conduction) aphasia - Speech and understanding normal, but cannot repeat words or phrases spoken by others
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Other language Areas Frontal Cortex: Parietal Cortex: Other parts of the Temporal Lobe:
Other language Areas Frontal Cortex: _ Brocas area and supplementary motor area - Language motor production _ Lateral prefrontal cortex - Complex processing of language comprehension & word analysis Parietal Cortex: _ Supramarginal & Angular gyri - Interpretation of spoken and written language Other parts of the Temporal Lobe: _ Association cortex - Coordinates auditory & visual aspects of language when naming objects or reading
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W/in the Temporal Lobe Fornix: Septum pellucidum:
W/in the Temporal Lobe Fornix: - Fibres to & from the hippocampus Septum pellucidum: - Membrane that separates lateral ventricles
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Functions of Lobes of the Cerebrum: INSULAR lobe Modulates:
Functions of Lobes of the Cerebrum: INSULAR lobe Modulates: - Emotions, homeostasis, cognition, perception, & self-awareness
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Insular Lobe Buried deep w/in the? Covered by portions of the?
Insular Lobe Buried deep w/in the? - LATERAL sulcus & forms part of its floor Covered by portions of the? - Temporal lobe - Parietal lobes - Frontal lobe
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Functions of Lobes of the Cerebrum: Occipital lobe Is the primary?
Functions of Lobes of the Cerebrum: Occipital lobe Is the primary? - Visual center of brain
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Primary visual cortex The gyri form the walls of the?
Primary visual cortex The gyri form the walls of the? - Calcarine sulcus
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POSTERIOR Cerebral Artery supplies?
POSTERIOR Cerebral Artery supplies? - The MEDIAL aspect of the hemispher (POSTERIOR 1/3), occipital lobes, inferior temporal lobe regions, brainstem, 3rd and lateral ventricles
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Occipital Lobe Primary visual cortex damage (posterior cerebral artery) = Visual association areas w/in the occipital lobe: Visual association area damage (POSTERIOR cerebral artery) = ?
Occipital Lobe Primary visual cortex damage (posterior cerebral artery) = - Cortical blindness Visual association areas w/in the occipital lobe: - Communicate w/ primary visual cortex - Interpret visual stimuli & identify things we see, except for faces (temporal association cortex) Visual association area damage (POSTERIOR cerebral artery) = Visual agnosia; - hemianopsia = visual deficit)
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Stroke-related Dysfunction POSTERIOR cerebral artery:
Stroke-related Dysfunction POSTERIOR cerebral artery: - Contralateral homonymous hemianosia 9visual loss in half the visual field in both eyes)
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Know the external Features of the Cerebral Lobes - L4, page 52
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Know the Deficit - L4, page 53
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L5 learning objectives - Identify the three types of white matter tracts - Identify and describe the components, and general functions of the diencephalon - Describe the components, connections, function & dysfunction of the basal ganglia
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Cerebral White Matter A major contributor to? Responsible for communication: Consist largely of?
Cerebral White Matter A major contributor to? - Cerebral volume Responsible for communication: - (i) b/w cerebral area - (ii) b/w the cerebral cortex & lower CNS centres Consist largely of? - Myelinated axons bundled into large tracts
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Cerebral White Matter PROJECTION TRACTS Extend vertically from brain to spinal cord w/in the one hemisphere, forming the?
Cerebral White Matter PROJECTION TRACTS Extend vertically from brain to spinal cord w/in the one hemisphere, forming the? - Internal capsule
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Cerebral White Matter COMMISSURAL TRACTS Cross from? Corpus callosum is a wide band of?
Cerebral White Matter COMMISSURAL TRACTS Cross from? - One hemisphere to the other Corpus callosum is a wide band of? - Myelinated axon tracts
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COMMISSURAL TRACTS - CORPUS COLLOSUM - Have a look at L5 slide 6
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Commissural Tracts - ATERIOR COMMISSURE Includes axons that connect?
Commissural Tracts - ATERIOR COMMISSURE Includes axons that connect? - The middle & inferior temporal gyri of the two sides
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Cerebral White Matter ASSOCIATION FIBRES Connect?
Cerebral White Matter ASSOCIATION FIBRES Connect? - Connect lobes & gyri w/in the hemisphere
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Summary: Tracts of the Cerebral White Matter L5, page 10
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Diencephalon Consist of 4 parts: Associated with the?
Diencephalon Consist of 4 parts: - Thalamus - Hypothalamus - Epithalamus - Subthalamus Associated with the? - 3rd ventricle
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Thalamus Structure? Makes up what percentage of the diencephalon? Forms the?
Thalamus Structure? - Egg-shaped Makes up what percentage of the diencephalon? - 80% Forms the? - Superolateral walls of the third ventricle
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Thalamus Contains? Interthalamic adhesion (intermediate mass): Play a key role in?
Thalamus Contains? - About a dozen nuclei ``` Interthalamic adhesion (intermediate mass): - A midline connection which joins each thalamus to the other ``` Play a key role in? - Relaying sensation - Motor activities - Cortical arousal - Learning & memory
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Hypothalamus Located? Forms the? Extends from the? Superior to the?
Hypothalamus Located? - Below the thalamus (hypothalamic sulcus) Forms the? - Inferolateral wall of the third ventricle Extends from the? - Optics chiasma Superior to the? - Brainstem
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Main Homeostatic Roles of Hypothalamus Autonomic control centre: Emotional response: Body temperature regulation: Regulation of food intake: Regulation of water balance and thirst: Regulation of sleep-wake cycles: Control of endocrine system functioning:
Main Homeostatic Roles of Hypothalamus Autonomic control centre: - Respiration, cardiovascular Emotional response: - Limbi system Body temperature regulation: - Thermosensitive neurons Regulation of food intake: - appetit & satiety centres Regulation of water balance and thirst: - Thirst centre Regulation of sleep-wake cycles: - With pineal gland Control of endocrine system functioning: - ovaries, testes to produce egg, sperm, stress hormones
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Epithalamus Structure? Includes? Contains? Pineal gland generate?
Epithalamus Structure? - A small, cone-shaped body Includes? - Pineal gland and the roof of the third ventricle Contains? - Dense calcium salts (pineal sand) in adults (radiopaque) Pineal gland generate - MELATONIN - the sleep - inducing signal (peak level at night)
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Diencephalon who am I L5, page 22
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Basal Ganglia Important for? Basal ganglia =? Corpus Striatum =? Other commonly used terms: Striatum =? Pallidum =?
Basal Ganglia Important for? - Motor control and attentional processes Basal ganglia =? - Corpus striatum + subthalamic nuclei + substantia nigra Corpus Striatum =? - Lentiform (putamen & globus pallidus) + caudate nuclei ``` Other commonly used terms: Striatum =? - Putamen + caudate nucleus Pallidum =? - Globus pallidus external (GPe) & internal (GPi) divisions ```
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Basal Ganglia: Corpus Striatum - L5, page 24
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Basal Ganglia: Corpus Striatum - L5, page 24
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Corpus Striatum Draw - L5, page 26
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Corpus Striatum What makes up the Internal capsule?
Corpus Striatum What makes up the Internal capsule? - Anterior limb - Genu - Posterior limb
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Corpus Striatum Posterior limb of internal capsule is b/w? Anterior limb of internal capsule is b/w?
Corpus Striatum Posterior limb of internal capsule is b/w? - Lentiform nucleus and thalamus Anterior limb of internal capsule is b/w? - Lentiform & caudate nuclei
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Locate the Putamen, Globus pallidus & caudate nucleus L5, page 29
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Locate the Globus pallidus, Caudate nucleus, thalamus, Putamen & Internal capsule - L5, page 30
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Basal ganglia: Connectivity with the Motor Cortex Access to motor neurons in the cerebral cortex is through the? What loop is this?
Basal ganglia: Connectivity with the Motor Cortex Access to motor neurons in the cerebral cortex is through the? - Thalamus What loop is this? - cortical-basal ganglia-thalamic-cortical loop
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Motor Control by Basal ganglia Output inhibits? Acts as a brake so to? The brake can be released by?
Motor Control by Basal ganglia Output inhibits? - Unnecessary movements Acts as a brake so to? - Produce ordered, finely controlled movement only when needed The brake can be released by? - Input from the cerebral cortex and the substantia nigra to start movement
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At rest: What inhibits the thalamus? What does this mean? What activates the putamen? What does the putamen inhibit? What does it activate? What does this cause? What does the basal ganglia influence?
At rest: What inhibits the thalamus? What does this mean? - Globus pallidus inhibits thalamus, no motor cortex activity What activates the putamen? What does the putamen inhibit? What does it activate? - Cortex activates putamen, which inhibits the globus palladus, releasing thalamus from inhibition, activating motor cortex What does this cause? - Movement What does the basal ganglia influence? - The function of spinal cord motor neurons INDIRECTLY (compared to cerebral cortex, direct synaptic input)
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Parkinsons Disease What type of degeneration? Motor deficits: Treatment:
Parkinsons Disease What type of degeneration? - Substantia nigra dopamine neuron degeneration Motor deficits: - Rigidity - Tremor - Difficulty initiating movement - Postural instability - Shuffling gait - Stiff facial expression (mask-like face) Treatment: - 1) replacement of dopamine - 2) Stem cell therapy - 3) Deep brain stimulation
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Basal Ganglia True or False L5, page 37
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