First parts

Question 1

What is PM tox

Answer 1

Applied Science
Hybrid of analytical chemistry and fundamental toxicologic principles: Anatomy,biology, clinical chemistry, Medicine, pharmacology, physiolog
While toxicology admits of being extensively applied to other medical science , it is in medical jurisprudence that its power and extent are most evident

Question 2

Objectives

Answer 2

Determine the nature and extent of drug involvement in potential human poisoning
Facts and opinions

Question 3

Objectives Fact

Answer 3

Maintain integrity of biological specimens during collection,storage and analysis to prevent spoilage or contamination
Isolate and identify specific chemical substance in biological specimens using appropriate techniques
Determine the absence of other drugs in specimens
Confirm and quantitate drugs
Report analytical findings

Question 4

Objectives Opinion

Answer 4

Interpreting, when experience allows, results in terms of the effects of the drugs found on behavior and health
Supply information, when possible, regarding dose od the drug ingested/exposed to, interval since ingestion/exposure, route and frequency of administration, and other factor pertaining to exposure
Express conclusion, based upon analytical results and other pertinent information, as to whether results are consistent with history of the incident

Question 5

Early History

Answer 5

oldest scientific displine
needed to know which plants were safe
Chinese journals, egyptians

Question 6

Toxicology derived from

Answer 6

Toxicon
Meant a bow for shooting arrows
Poison occasionally placed on tips of arrows to increase lethality
Word toxicos came to refer to such a poison
Lead to term intoxication initially meant one was made sick by poison arrows

Question 7

Romans

Answer 7

Assisnations and executions
Nero used personal poisoner

Question 8

1200

Answer 8

spanish rabbi wrote 1st aid book poison and theoir antidotes

Question 9

paracelsus-Important

Answer 9

father of modern tox
“All things are poison and nothing is without poison, only the dose permits something not to be poisonous”
Substances considered toxic are harmless in small doses and conversely an ordinarily harmless substance can be deadly if over consumed

Question 10

When did poisoning reach the height

Answer 10

Renaissance

Question 11

Borgias clan

Answer 11

15th Century widely known
Brother and sister
famous posioners

Question 12

Catherine de medici

Answer 12

Tested her poisons on the poor and ill
Schools in rome and Venice
Taught how to murder w/ poiso

Question 13

Arsenic Act

Answer 13

Documentation of
Purchaser, AMt. sold, purpose of use, requires colorant; exception-medicinal or agricultural
Repealed in 1933 [Pharmacy and poisons act]