First Order and Zero Order Elimination

Question 1

First order elimination is

Answer 1

dA/dt=-kA

Question 2

The order of a reaction refers to the way in which the concentration of drug or reactants influences the _________of a process

Answer 2

rate

Question 3

The rate of a first order kinetic process is proportional to the ____________(of ___________) of the drug

Answer 3

amount (of concentration)

Question 4

First order elimination

The rate of drug elimination decreases as the amount of _________ in the body decreases

Answer 4

drug

Question 5

The unit of first-order rate constant is __________

Answer 5

1/time (e.g., 1/min)

Question 6

First Order Elimination

The elimination half life of a first order process is ____________ and does NOT depend on the dose

Answer 6

constant

Question 7

Elimination half life

Most drugs are eliminated from the body by a _________________

Answer 7

first order kinetics

Question 8

For any first order decaying process, the half life is the time necessary for that process to decay by half

Question 9

The elimination half-life is the time a given concentration takes to decay by half

Question 10

Units for the first order rate constant: reciprocal time, time^-1 (e.g min^-1,h^-1, day^-1)

Question 11

Zero Order Process

dA/dt=-K0

The rate is _____________all the time

The rate does NOT depend on the amount of the drug

The unit of the zero order rate constant is _______/________

(e.g., it does not matter what concentration of the drug in the bloodstream is; it will be eliminated at a fix rate no matter)

Answer 11

constant

mass/time

Question 12

Zero Order Process

C=C0-K0xt
C0 is the drug concentration at time 0, C is the concentration at time t, and k0 is the zero order rate constant

If you plot the graph on linear graph paper you will see a straight line. This is one way to tell if the process is a zero order elimination process. You can then derive an equation to determine concentration at any time T on the curve

Question 13

Zero Order Reaction

Equation:dC/dt=k0

Question 14

Zero Order reaction

Rate constant units

Answer 14

(mg/L)/h

Question 15

Zero-order reaction Half-Life

t 1/2=

Answer 15

t 1/2=0.5C/K0(not constant)

Question 16

Zero Order reaction

Effect of time on rate: Zero-order rate is ____________with respect to time

Answer 16

constant

Question 17

Zero Order reaction

Effect of time on rate constant: Rate constant with respect to time….

Answer 17

changes as the concentration changes

Question 18

Zero-Order reaction
Drug concentrations versus time plotted on rectangular coordinates: Drug concentrations decline __________for a zero-order rate process

Answer 18

linearly

Question 19

First-order reaction

dc/dt=kC

Question 20

First-order reaction
rate constant-units:

Answer 20

1/h

Question 21

First-order reaction
Effect of time on rate: First order rate will change with respect to time as _____________ changes

Answer 21

concentration

Question 22

First-order reaction
Half-Life: t 1/2=

Answer 22

t 1/2=0.693/k(constant)

Question 23

First-order reaction

Effect of time on rate constant: Rate constant remains _______________ with respect to time

Answer 23

constant

Question 24

First-order reaction

Drug concentrations versus time-plotted on rectangular coordinates: Drug concentrations decline __________ for a first order rate process

Answer 24

nonlinearly

Question 25

First order reaction

Drug concentrations versus time plotted on a semilogarithmic graph

Drug concentrations decline __________ for a single first-order rate process

Answer 25

linearly

Question 26

Zero-Order reaction

Drug concentrations versus time-plotted on a semilog graph

Drug concentrations decline ___________for a zero order rate process

Answer 26

nonlinearly