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Pharmacotherapy > first line antihypertensive > Flashcards

first line antihypertensive Flashcards

1
Q

what are the first line anti hypertensives?

A

ace-i
arb
thiazides
CCB

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2
Q

what are some of the ACE-I meds?

A

lisinopril
ramipril
benazepril
fosinopril

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3
Q

what are the compelling indications for ACE-I?

A

CKD
HF
DM
post MI
recurrent stroke

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4
Q

which race response better to ACE-I?

A

whites

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5
Q

which is the ACEI of choice?

A

lisinopril

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6
Q

caution and contraindication of ACEI?

A

caution in renal insufficiency
contraindicated in: pregnancy, RAS, angioedema

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7
Q

what are ACEI common AEs?

A

cough
HYPERKALEMIA
increased SCr
postural hypotension
AKI

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8
Q

what are some ARB meds?

A

losartan
telmisartan
valsartan
olmesartan

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9
Q

which race response better to ARBs?

A

whites

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10
Q

caution and contraindication of ARBs?

A

caution in renal insufficiency
contraindicated in: pregnancy, RAS

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11
Q

what are ARBs common AEs?

A

HYPERKALEMIA
postural hypertension

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12
Q

what are the dihydropyridine CCBs?

A

amlodipine
felodipine
nicardipine
nifedipine

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13
Q

what are the patient selections for CCB?

A

blacks
elderly
angina
PVD
migraine

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14
Q

which formulation of CCB to be avoided because increased mortality?

A

IR FORMULATION

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15
Q

what are the AEs for CCB as a whole class?

A

HA
dizziness
postural hypotension

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16
Q

what are the AEs for dihydro CCB?

A

GERD
edema
flushing
reflex tachy
gingival hyperplasia

17
Q

what are the AEs for nondihydro CCB?

A

bradycardia
heart block
CONSTIPATION with VERAPAMIL
worsen HF
CYP3A4 I

18
Q

what are the non-dihydropyridine CCB?

A

Diltiazem
Verapamil

19
Q

what are the thiazide meds?

A

HCTZ
chlorthalidone
metolazone
indapamide

20
Q

which two thiazides are better in renal insufficiency?

A

metolazone
indapamide

21
Q

thiazides cross sensitivity with what?

A

sulfa

22
Q

who response better to thiazide?

A

blacks
ISH

23
Q

what are thiazide AEs?

A

HYPOKALEMIA
hyperlipidemia
hyperglycemia
hyperuricemia
hypercalcemia

24
Q

what’s good about thiazide in regards to bone protection?

A

protect against hip fractures

Pharmacotherapy (3 decks)

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