first line antihypertensive Flashcards
what are the first line anti hypertensives?
ace-i
arb
thiazides
CCB
what are some of the ACE-I meds?
lisinopril
ramipril
benazepril
fosinopril
what are the compelling indications for ACE-I?
CKD
HF
DM
post MI
recurrent stroke
which race response better to ACE-I?
whites
which is the ACEI of choice?
lisinopril
caution and contraindication of ACEI?
caution in renal insufficiency
contraindicated in: pregnancy, RAS, angioedema
what are ACEI common AEs?
cough
HYPERKALEMIA
increased SCr
postural hypotension
AKI
what are some ARB meds?
losartan
telmisartan
valsartan
olmesartan
which race response better to ARBs?
whites
caution and contraindication of ARBs?
caution in renal insufficiency
contraindicated in: pregnancy, RAS
what are ARBs common AEs?
HYPERKALEMIA
postural hypertension
what are the dihydropyridine CCBs?
amlodipine
felodipine
nicardipine
nifedipine
what are the patient selections for CCB?
blacks
elderly
angina
PVD
migraine
which formulation of CCB to be avoided because increased mortality?
IR FORMULATION
what are the AEs for CCB as a whole class?
HA
dizziness
postural hypotension
what are the AEs for dihydro CCB?
GERD
edema
flushing
reflex tachy
gingival hyperplasia
what are the AEs for nondihydro CCB?
bradycardia
heart block
CONSTIPATION with VERAPAMIL
worsen HF
CYP3A4 I
what are the non-dihydropyridine CCB?
Diltiazem
Verapamil
what are the thiazide meds?
HCTZ
chlorthalidone
metolazone
indapamide
which two thiazides are better in renal insufficiency?
metolazone
indapamide
thiazides cross sensitivity with what?
sulfa
who response better to thiazide?
blacks
ISH
what are thiazide AEs?
HYPOKALEMIA
hyperlipidemia
hyperglycemia
hyperuricemia
hypercalcemia
what’s good about thiazide in regards to bone protection?
protect against hip fractures
