First Aid - Renal Pathology II

Question 1

What are the characteristic LM, IF, and EM findings in Focal Segmental Glomerulosclerosis?

Answer 1

LM - Segmental sclerosis and hyalinosis, IF - negative, EM - Effacement of foot processes similar to minimal change disease.

Question 2

What are the ethnic group associations and etiologies of Focal Segmental Glomerulonephritis?

Answer 2

FSGS is the most common cause of nephrotic syndrome in African Americans and Hispanics. Can be idiopathic or associated with: HIV, sickle cell, heroin abuse, massive obesity, interferon treatment, chronic kidney disease

Question 3

What is the treatment and prognosis of FSGS?

Answer 3

Steroid therapy. Inconsistent response, may lead to chronic renal disease.

Question 4

What are the characteristic LM, IF, and EM findings in Membranous Nephropathy?

Answer 4

LM - Diffuse capillary and GBM thickening, IF - Granular as a result of immune complex deposition (Nephrotic presentation of SLE), EM - “Spike and Dome” appearance with sub-epithelial deposits.

Question 5

What are the ethnic group associations and etiologies of Membranous Nephropathy?

Answer 5

Most common cause of primary nephrotic syndrome in Caucasian adults. Can be idiopathic or associated with: Phospholipase A Antibodies, Drugs (penicillamine, NSAIDs), Infections (Hep B & C), SLE, or solid tumors.

Question 6

What is the treatment and prognosis of Membranous Nephropathy?

Answer 6

Poorly responsive to steroid treatment, may progress to chronic renal disease.