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AUBF - Lab > FINALS - CSF > Flashcards

FINALS - CSF Flashcards

1
Q

Considered as 3rd Major body fluid

A

Cerebrospinal Fluid

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2
Q

FUNCTIONS of CSF

A
  • Supply nutrients to the CNS
  • Remove metabolic waste
  • Produce a mechanical barrier to cushion the
    brain and spinal cord against trauma
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3
Q

Lines the brain and spinal cord

A

Meninges

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4
Q

outer layer, lines the skull and vertebral
canal

A

Dura Mater

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5
Q

▪ spider-like, filamentous inner
membrane

A

Arachnoid mater

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6
Q

▪ innermost layer
▪ lines the surface of the brain and
spinal cord

A

Pia Mater

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7
Q

▪ In between Arachnoid mater and Pia
mater
o where CSF flows

A

Subarachnoid space

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8
Q

specific part of the brain that produces CSF

A

Choroid Plexus

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9
Q

Choroid Plexus Ventricles

A

○ Choroid plexus of the third ventricle
○ Choroid plexus of the fourth ventricle
○ Choroid plexus of the lateral ventricle

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10
Q

Choroid Plexus are capillary networks that form the CSF from plasma by mechanisms of:

A
  • selective filtration under hydrostatic
    pressure;
  • active transport secretion
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11
Q

T or F

The chemical composition of the CSF resemble an ultrafiltrate of plasma

A

False

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12
Q

Rate of CSF Production

A

20 ml/hr

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13
Q

Reabsorbs CSF

A

Arachnoid vili / Granulations

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14
Q

● tightly fitting junctures structure of endothelial cells in choroid plexus
● Protects the brain from chemicals and other
substances circulating in the blood that can harm the brain tissue

A

Blood Brain Barrier (BBB)

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15
Q

Disruption of BBB allows substances to enter the CSF such as:

A

WBC
Protein
Other Chemicals (High Molecular Weight)

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16
Q

CSF SPECIMEN COLLECTION

A

○ Lumbar puncture/tap
■ (Between the 3rd, 4th, or 5th lumbar vertebrae)
○ Cisternal puncture

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17
Q

CSF SPECIMEN Volume to be collected

A
  • Up to 20 ml collected under normal pressure, which is approximately 15% of the estimated total CSF volume
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18
Q

IF CSF is not normal (lesser, greater), what is the volume to be removed?

A

only 1-2 ml

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19
Q

Normal CSF Volume of ADULT

A

90-150 mL

20
Q

Normal CSF Volume of NEONATES

A

10-60 mL

21
Q

CSF Tube 1 - Lab Section

A

● Chemistry
● Immunology
● Serology

22
Q

CSF Tube 2 - Lab Section

A

● Microbiology
○ Gram Stain
○ Culture and Sensitivity

23
Q

CSF Tube 3 - Lab Section

A

● Hematology (Cell count)
● Cytology studies

24
Q

CSF Tube 4 - Lab Section

A

● Microbiology (better exclude skin
contamination)
● Serology (for additional serologic test)

25
Q

○ Tubed used to check cellular
contamination=

A

Tube 1 and 4

26
Q

CSF Appearance - Crystal Clear

A

Normal

27
Q

CSF Appearance - Cloudy, Turbid, Milky

A

● Increase WBC= >200/uL
● Increase RBC= >400/uL
● Presence of Microorganisms
● Increased Proteins and Lipids

28
Q

CSF Appearance - Xanthochromic - PINK

A

slight amount of oxyhemoglobin

29
Q

CSF Appearance -Xanthochromic - YELLOW

A

Bilirubin

30
Q

CSF Appearance - Xanthochromic - ORANGE

A

in case of heavy hemolysis

31
Q

CSF Appearance - Xanthochromic - BROWNISH

A

Methemoglobin Formation

32
Q

CSF Appearance - Xanthochromic - OTHER CAUSES

A

● Increase dietary carotene
● Increase rifampin intake
● Increase melanin
● Normal neonate
● Protein concentration exceeding 150mg/dL
● Previous traumatic tap

33
Q

CSF Appearance - Bloody/Grossly bloody

A

● RBCs: >6000/uL due to
○ Traumatic tap
○ Intracranial hemorrhage/ Cerebral hemorrhage

34
Q

CSF Appearance - Oily

A

Radiographic contrast dye

35
Q

CSF Appearance - Clotted

A

● Protein and clotting factors
● Meningitis
● Froin’s syndrome

36
Q

CSF Appearance - Pellicle

A

Tubercular meningitis

37
Q

Clear Appearance - DILUTION

A

Undiluted

38
Q

Slightly Hazy Appearance - DILUTION

A

1:10

39
Q

Hazy Appearance - DILUTION

A

1:20

40
Q

Slightly cloudy Appearance - DILUTION

A

1:100

41
Q

Cloudy/Slightly bloody Appearance - DILUTION

A

1:200

42
Q

40% of WBC disintegrates within

A

2 hours

43
Q

CSF WBC Count diluting fluid

A

3% glacial acetic acid (HAc) with Methylene Blue

44
Q

Normal CSF WBC Count of Adults

A

0-5 WBCS/ul

45
Q

Normal CSF WBC Count of Neonates

A

0-30 WBCs/ul

46
Q
A

AUBF - Lab (3 decks)

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