Final Written Flashcards
Which condition presents with narrowing pores due to proliferation and accumulation of keratinocytes and skin edema? Sebum builds up in blocked follicle.
Acne
Inflammation of comedone results from:
Leakage of sebum into dermis and secretion of proinflammatory mediators, chemokines, and degradative enzymes by P. acnes.
Excessive mTORC signaling, high insulin and IGF-1 levels, mTORC (more mTORC, more inflammation), increases both expression of inflammatory biomarkers and also sebum production in sebocytes are all causes of what condition?
Acne
________ propagates mTORC (animal products)
Leucine
Pathogenic factors targeted by treatment of acne, what is the major factor?
keratinocyte hyperproliferation
Which western medicine treatment of acne is teratogenic?
Isotretinoin (acutane)
Antibiotics to treat acne are more effective if combined with _______ _______ or _________, and should be stopped after what period of time?
Benzoyl peroxide or retinoids, after 3-6 months
What are 4 botanical (topical) treatments for acne?
- Azelaic acid
- Green tea
- Tea tree oil
- Calendula succus
What are 5 botanical (internal) treatments for acne?
- Berberine (barberry, coptis)
- Oregon grape (goldenseal)
- Chasteberry
- Indian gooseberry
Which 3 physical medicine treatments can be done for acne?
- Sun (start with 5 min/day)
- Hot/cold contrast bath w/ green tea
- Calendula
Which 6 mineral supplements can be used for treating acne?
- Zinc
- Copper
- Chromium
- Selenium
- Omega 3
- Vitamin D
The following s/sx are indicative of which condition?
Erythema, telangiectasia, papulopustule, nodules, no comedones, Rhinophyma (mainly males), Demodex mite, migraines (3x more common), 30-50% have ocular symptoms (iritis, scleritis, keratitis, chalazia, blepharoconjunctivitis)
Rosacea
Aggravation by fluoride and sodium lauryl sulfate are possible causes of which condition?
Perioral dermatitis
T/F: Topical glucocorticoids are useful in treating perioral dermatitis
FALSE! Avoid using topical glucocorticoids for perioral dermatitis
What are 7 risk factors for hidradenitis suppurativa?
- obesity
- female
- smoking
- acne vulgaris
- IBD
- low zinc
- SAD