fINAL: sULFONOMIDES, mACROLIDES, aNTIVIRALS, aNTIFUNGALS Flashcards
1
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macrolides/lincosamides, sulfonmides
What can you say about sulfonamides?
A
MOA: inhibit the formation of pteroic acid through the inhibition of dihydropetrate synthase (DHPS) by acting as a false substrate/competitive inhibitor. interere with synthesis of folic acid (does not happen in animals).
bacteristatic. broadspectrum.
resistance: production of insenesitive dihydropteroate enzyme or hyperproduction of PABA.
PK: precipitate out and form crystals. acetylation.
toxicity: urinary tract, liver, derm, keratoconjunctivitis. drug fever hypersenesitivity. do not use in doberman pinschers. good in combination with “oprims”
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