Final stuff with Bhat Flashcards
What are the benefits of dietary supplements?
Minimum side effects
Prevention and treatment
What are the risks of dietary supplements?
Lack of/poorly designed studies
PLACEBO EFFECT
What does echinacea do?
Increases phagocytosis, total circulating WBC, monocytes, neutrophils, and NK cells
So increases immunity in colds and other RTI
What are the overall results of echinacea?
Increased immunity, leading to decreased symptoms and duration of illness, and increased hematologic recovery following chemo
What is echinacea ineffective in treating?
Genital herpes
What are the DDI for echinacea?
High alcohol content
Patients that have immune deficiency’s
What are the pharmacological effects of garlic?
CV- Decreases atherosclerosis
Inhibits HMG-CoA reductase
How does garlic effect cholesterol? Overall and LDL
Lowers overall cholesterol but does not lower LDL
What is garlics antineoplastic effects?
Reduces incidence of stomach, esophageal, and colorectal cancer
What is garlics DDI?
Anticoagulant meds
Decreased bioavailability of saquinavir
What is ginkgos beneficial properties?
Antioxidant and radical scavenging properties
What are the CV effects seen in ginkgo?
Increases blood flow, reduced blood viscosity, and vasodilation
Increased endogenous NO, antagonize platelet activating factor
What are the CNS effects of ginkgo?
Increased muscarinic receptors, decreased B adenoreceptors
Increased serum levels of ach and NE
Inceased synaptosomal reuptake of serotonin
Decreased corticosteroid synthesis
Decreased amyloid B fibril formation
What are the uses of ginkgo?
Cerebral insufficiency
Dementia
Prophylactic agent to prevent dementia progressioun
What is ginkgo ADEs?
Comparable to placebo
What is ginkgos DDI?
Anticlotting meds-Dont use together!!!
Preexisting seizure disorder-Avoid all together
Trazadone-enhanced sedative effect
What is ginsengs benefits?
Modulation of immune function, increases mRNA levels of interleukons
Increased levels of ach serotonin, NE, and dopamine in the cerebral cortex
Antioxidant, analgesic, antiplatelet, anticancer
What is the general belief of ginsengs benefits?
Improved physical and mental performance
Decreases cold incidence and duration
Decreased postprandial glucose
What are ginsengs DDIs?
Anticlotting meds-avoid nsaids and anticlotting stuff
What is st johns wort benefits?
Antidepressant by acting as an MAO A and B inhibitor
Inhibition of MAO causes increased levels of serotonin
What is the ades of st johns wort?
Serotonin syndrome
Induction of CYPS and P-GP
What is the clinical benefits of CoQ?
Decreased systolic BP and distolic BP
Treating ischemic heart disease
ultimately, decreases myopathic pain
