final set of lectures Flashcards
primary or secondary:
decreased cellular activity (hypo) -OR- increased cellular activity (hyper) of the endocrine gland
primary
primary or secondary:
– a lesion of another organ leads to decreased (hypo) or increased (hyper) cellular activity of the endocrine gland
secondary
patient presents with •bilareral apolecia • Polyphagia • PU/PD • Pot belly • Stinks
producing too much cortisol – hyperadrenocorticism
cushings patient
MDx: adenocortical carcinoma
canine cushings liver histo will look like
Vacuolar hepatocellular degeneration
Consistent with “steroid hepatopathy” of hyperadrenocorticism
most adrenal tumors arise from this zone
fasciculata
primary hyperadrenocorticism is often due to what
adrenal tumor
secondary hyperadrenocorticism is often due to what
Adrenal cortical hyperplasia (due to ACTH
secreting pituitary adenoma)
arise from the pars distalis
most all are productive
real name for equine cushings
Pituitary Pars Intermedia Dysfunction (PPID)
T/F
PPID is a productive pituitary adenoma
FALSE - non productive
clinical signs of PPID
Clinical signs – Hirsuitism (failure to shed) – PU/PD – Polyphagia – Hyperhidrosis – Insulin resistance – Abnormal fat deposition
Due to adrenocortical atrophy
addisons
primary hypoadrenocorticism patients are deficient in ____ and ____
aldosterone and cortisol
cat adrenocortical neoplasm that produces signs due to hyperaldosteronism
Conns syndrome
Ferret adrenal neoplasm produces what hormone
estrogen – cortisol will be normal
Things that decrease T4
- Iodine deficient diet
- Goiterogenic substances -
- Congenital dyshormonogenic goiter
- Excess dietary iodide
2 causes of secondary hyperparathyroidism
renal and nutritional
Fibrous osteodystrophy associated with what endocrine disorder
hyperparathyroidism – – PTH stimulates increased
resorption of bone
Chronic PTH also stimulates bone marrow stromal cells to
differentiate into fibroblasts
insulinoma are also called
Pancreatic Islet Cell Tumors
T/F
most insulinomas are benign
false – malignant
what do insulinomas lead to
HYPOglycemia – seizures and death
clinical syndrome of hypoinsulinism
diabetes mellitus
T/F
all species can get cataracts associated with diabetes mellitus
FALSE – dogs only
low insulin = _____ glucose
high
Failureofdevelopmentof oneorbothkidneys
renal aplasia
