Final second half shit Flashcards
what is exercise
Any and all activity involving generation of force by activated mysckles that results in disruption of homeostasis
What is the main goal od the cardiorespiratory part of this exam
the rate limiting factors that influence ATP and the actin myosin crosbridges for exercise purposes
Bioenergetics
Essentially just ATP syntheiszation and how we get energy to create movemnt
Enzymes
The things that make reactions happen 1st rate limiter they catalyze reactions and usually end in Ase
catabolism - enzyme attaches to molecules and the molecule splits ATP-ADP
Synthesis - molecules combine ADP plus p - ATP
Creatine phosphate
Anaerobic system PCR creatine phosphate donates its phosphate ion to ADP to create ATP major limitation is creatine kinase presense of it in the system catalyzes ATP to ADP after it donates to turn into energy and is an enzyme
Other limitations are like the amount of creating phosphate total creatine
In the graph initially you have max ATp then start maximal anaerobic work initially goes down then PCr starts odnating to ADP make more ATp then gradual curve down as creatine kinase breaks down that ATP to tunr into ADP and energy and as PCr or creatine runs out in the system
Glycolysis
1 glucose to 2 pyruvate ATP NADH and hydorgen ions glucose you get 2 glycogen you get 3 and has a slower resynthesis of ATP
limitations is the availiboility of glucose and glycogen and the amount of phosphofructokinase the amount of lactate dehyrogenase acid production
pyruvate to lactae anaerobically
Lactate - lactate dehydrogenase catalyzes reaction between pyruvate and NADH and produces lactate NAD and H so glycolysis to lactate produces 4 hydrogen uons total
NAD resyntheis - required for glycolysis resynthesied from NADH pyruvate to lactate pyruvate to oxidative phosphoylation
limitation is amount of lactate dehydrogenase and acid production which can both be incresed with training
Hydrogen ions (acid)
Inhibit muscle contraction
Removal via bicarbonate biffering and transport to blood elim as co2 via respiration more training means more bicarbonate in muscle which will help remove those hydrogen ions another thing is that there is supplementation of bicarbonate which used to be popular but if you have too much there is a thin threshold of it and go over than diarrea occurs
Oxidative phosphorylation (aerobic system)
Mitochondiria two step processs to synthesise ATP krebs cycles and the electon transport chain
Krebs cycle
Acetyl coa is converted to ATP NADh and FADH 2 which enter the electorn transport chain Acetyl coa glucose to pyruvate amino acid to pyruvate fatty acids
limitations of this is the number of mitochondria and the citrate synthase and the succinate dehydrogensae
Electron transport chain
H removed from NADH and FADH to then resynthesise NAD and FAD 4 hydorgen ions combine to make water limitations of it is the number of mitochondria and the oxygen availibility peripeheral AVo2
Contributions to non steady state
longer duration the less ATp pcr has an impact also know the glycolytic system stays relatively the same no matter the duration
Relation to needs analysis
Anaeorbic power - limited by creatine phosphate and glycolysis
Anerobic threshold - limited by glycolysis and oxidative phosphorylation
aerobic power - limited by oxidative phosphorylation
Adaptations to exercise
SAID prinicple adaptation are specific to the bioenergetic system which must be stressed to ellicit adaptation there are motor unit specific peripeheral like the creatin phosphate and enzyme concentrations there are muscle speciifc peripheral like th enumber of mito and oxygen extraction and not specific to muscles used lie centeral oxygen delivery
Oxygen delivery and utilization
Fick equasion for vo2 cardiac output centeral factors storke vol to left ventricle chamber size and the AVo2 difference the peripheral factor extraction and utilization of oxygen
Oxygen extraction
incresed myoglobin concentration like o2 transferred from hemoglobin blood to myoglobinn muscle
incresed capillzarixzation more sites for o2 transfer between hemoglogin and myogobin
Avo2 differnce which can change based ipon how much you have trained at rest uou migh have artirial of 20 and a venos of 5 in untrianed so a 75 percent transfer whereas after training for 2 months you have artial of 20 and venous of 3 so a 85 percent transferknow that at rest its 20-17 artial to venus so just know these numbers go up during exercise