Final Review

Question 1

Diapedesis

Answer 1

Movement of immune cells from one side to the other across the epithelium (maybe specific to the BBB?)

Question 2

What is P-glycoprotein?

Answer 2

P-glycoprotein is one of several efflux transporters in the BBB

Question 3

Why are efflux transporters important for the BBB?

Answer 3

Because they pump therapeutic drugs out of the brain and prevent them from reaching their target!! Erlotinib is an anticancer drug that cannot cross the BBB in the presence of a ET

Question 4

glymphatic system

Answer 4

interstitial solute and fluid clearing from the brain

Question 5

tension headache pathophysiology

Answer 5

greater occipital nerve compression

Question 6

selegiline

Answer 6

selective MAO(b) inhibitor used in the treatment of Parkinson’s

Question 7

Dorsal columns of spinal cord

Answer 7

carry info regarding conscious proprioception and vibration (gracile fascicles + cuneate fascicles)

Question 8

sulcus limitans

Answer 8

longitudinal grove marks boundary on neural tube between alar (anterior, sensory) and basal (posterior, motor)

Question 9

Babinski sign

Answer 9

disappears during years 1-2 as myelination proceeds

Question 10

B12 Deficiency

Answer 10

anemia + subacute combined degeneration of spinal cord. Loss of myelination in corticospinal and (gracile fascicles + cuneate fascicles [both vibratory and proprioception])

Question 11

acetazolamide

Answer 11

carbonic anhydrase inhibitor

used in treating acute glaucoma and for decreasing CSF production

Question 12

furosemide

Answer 12

diuretic – Na/K/2Cl pump inhibtor

used to reduce production of CSF d/t hydrocephalus

Question 13

ouabain

Answer 13

inhibitor of Na/K ATPase

decreases CSF production

Question 14

diapedesis

Answer 14

immune cell migrator – Trojan Horse method of drug delivery