FINAL review Flashcards
antigens are
foreign substances to the body
Antigen processing involves the breakdown of protein antigens and the subsequent association of peptide fragments on the surface of antigen presenting cells with
MHC class 1 or class 2 molecules
clonal deletion of developing T lymphocytes takes place in which location of the body
thymus
in adults, B cell maturation takes place in the
bone marrow
normal response to infection is polyclonal production of antibodies
True
one of the advantages of adaptive immunity over innate immunity is
the response is targeted against a single pathogen
the antibody immune response is attributed to the action of
B lymphocytes
The Fc portion of the antibody is formed by
lower portions of the heavy chains
When a B cell encounters its corresponding antigen, it expresses more ____ in order to be more effective antigen presenting cell
MHC class 2
when B cell reacts directly against an antigen, independent of T helper cells, does it produce antibody
yes, IgM
Which cells have receptors for Fc portion of IgE
Mast cells
Which of the following are characteristics of a plasma cell?
it secretes identical antibodies all directed at a single unique epitope
Which of the following corresponds to the antigen binding site of immunoglobulins?
VH:VL
Which of the following statements regarding CD8 T cells is incorrect?
when activated, CD8 T cells in turn activate B cells
___ act as cellular messengers by delivering degraded pathogens to lymphoid organs:
dendritic cells
___ form dimers; whereas ___ form pentamers
IgA; IgM
the isotope of an antibody is determined by
constant region of heavy chain
The process of __ results in change in the constant region of the heavy-chain of antibodies, causing a change in the effector function and transport properties of antibodies
isotype switching
With the exception of B cells, all other cells of the body have the immunoglobulin genes in the
germline configuration
Which of the following is incorrectly matched?
helper T cells; CD8
After an initial exposure to a pathogen, the phenomenon of __ produces a faster, more effective response to subsequent exposures
immunological memory
