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Hematology 2 > final review > Flashcards

final review Flashcards

1
Q

what do suer rods indicate

A

myeloid not lymphoid leukemia

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2
Q

where are faggot cells common

A

M3 acute promyelocytic leukemia

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3
Q

FAB indication of acute leukemia

A

> 30% blasts in BM & >5 % in blood

M0- acute myeloblastic leukemia (AML)

M3- Aute promeylocytic leukemia ( APL)- hypergranular promyelocytic

M4- acute myelomonocytic leukemia (AMML) - naegeli

M5- acute monocytic leukemia-a&b ( AMoL)- schillingg (a)

M6- erytholeukemia (AEL) - Di Guglielmo syndrome

m7 - megakaryoblastic leukemia ( AMegL)

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4
Q

AML

A

M0

common in adults

increased myeloblasts

NRBCs

thrombocytopenia

> 30% blasts in BM

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5
Q

ALL

A

acute lymphoblastic leukemia

common in children

increased lymphoblasts

L1 - scanty cytoplasm, small
L2 large, lots of cytoplasm, indented nucleus
L3 (Burkitts) - large lots of basophilic cytoplasm, vacuoles

splenomegaly

NRBCs

thrombocytopenia

> 50% lymphoblasts

serum uric acid & LD may be increased

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6
Q

AMoL

A

M5

bleed disorder
splenomegaly
infections
extramedullary : lymoh nodes, skin, liver, spleen, CNS

M5a - schillings type 
poorly differentiated 
monoblasts 
chromosome 11 band q 23 
younger age 
M5b 
well differentiated 
promonocytes 
nucleus has more folding/ lobulation 
adults
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7
Q

AMML

A

M4- naegleri

monocytic & granulocytic differentiation
the myeloblast stains positive for MPO or SBB

M4Eo 
-AMML associated with BM eosinophilia 
- inversion of chromosome 16 
- shows myeloid and monocytic differentiation
stains postive for MPO, SBB & NSE
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8
Q

APL

A

Acute promyelocytic leukemia - M3

> 30% of non RBCs

heavy granulation ( sometime obscures nucleus )

abundant cytoplasm

bundles of auer rods ( faggot cells)

translocation of 15; 17 that leads to gene fusion

bleeding episodes
- DIC ( abnormal promyelocytes produce tissue like substances that triggers DIC)

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9
Q

AEL

A
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10
Q

AmegL

A
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11
Q

what is the lap score of a leukmoid reaction vs CML

A

leukmoid reaction has an increased lap score

CML has a low lap score unless there is an infection ( also left shift & higher WBC count ) `

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12
Q

differences betweene ALL & AML

A

AML

  • children
  • granules/ auer rods
  • MPO & SBB +
  • TdT -

ALL

  • adults
  • MPO & SBB -
  • TdT +
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Hematology 2 (4 decks)

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