Final - Lecture 9

Question 1

Analysis of SNPs across can be used to?

Answer 1

compare breeds, genomic disequilibrium

Question 2

Pattern frequency variation between breeds is evidence for?

Answer 2

selection changing the genome (selection for and retaining)

Question 3

What is indicative of an association in a Manhattan plot?

Answer 3

Spikes

e. g. curly tails = two spikes
e. g. drop ears = single point
e. g. social behaviour = single point –> localized to specific chromosome, but difficult to determine gene/group of gene involved

Question 4

Single locus selection

Answer 4

gaited horse breeds, height of draft and small horses, muscle fiber type

Question 5

Gaited horse breeds associated with what gene?

Answer 5

DMRT3 - horses with specific allele at this locus –> extension of back leg changing mechanism of gait

Question 6

Gene involved in horse breed height?

Answer 6

ECA11 = equus cabals chromosome 11

Question 7

How can we undo selection problems?

Answer 7

• alter selection goals to reverse trend
• find less selected populations/strains (gene conservation/isolated populations)
• use cry-preserved genetic material (AI or embryo transfer)
• give up and start over

Question 8

Marker assisted introgression

Answer 8

natural process but should fall under GMO - including alleles from elsewhere and monitor progress

Question 9

SMART goals

Answer 9

specific
measurable
attainable
realistic
timely