final lecture 9 Flashcards
HAT
plt sequestration
HIT
IgG antibodies
diagnosis of HIT
4T score thrombocytopenia timing thrombosis other
agratroban dose
DTI
alt. anticoag in HIT
2mcg/kg/min
goal aPPTL 1.5-3
lepirudin
DTI
alt. anticoag in HIT
aPTT 4 hours after initiation: 1.5-2
bivalirudin
DTI
alt. anticoag in HIT
drug induced thrombocytopenia
quinine, quinidine, vancomycin, heparin, pip/tazo
drug-induced aplastic anemia
2 of theses:
WBC<30,000
severe aplastic anemia
2 of these:
ANC<20,000
anemia
drug induced aplastic anemia causes
chloramphenicol, felbamate, antineoplastic agents
drug induced agranulocytosis causes
beta-lactam ABX, valprioc acid, clozapine
agranulocytosis management
GF support for chemo induced
drug induced hemolytic anemia diagnosis
coombs test
hemolytic anemia drug causes
beta-lactam ABX, methyldopa
drug induced oxidative hemolytic anemia most common cause
G6PD deficiency
drugs- dapsone, sulamethoxazole
drug induced megaloblastic anemia causes
metformin, methotrexate, phenytoin & phenobarbital
megaloblastic anemia treatment
folate & vit B12
